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- W3202055168 abstract "The modification of peptides and proteins has emerged as a powerful means to efficiently prepare high value bioconjugates for a range of applications in chemical biology and for the development of next-generation therapeutics. Herein, we report a novel method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with suitably functionalised diaryliodonium salts, furnishing stable thioether-linked synthetic conjugates. The power of this new platform is showcased through the late-stage modification of the affibody zEGFR and the histone protein H2A." @default.
- W3202055168 created "2021-10-11" @default.
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- W3202055168 date "2021-01-01" @default.
- W3202055168 modified "2023-10-17" @default.
- W3202055168 title "Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts" @default.
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- W3202055168 doi "https://doi.org/10.1039/d1sc03127a" @default.
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