FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202068700> ?p ?o ?g. }

• W3202068700 endingPage "105197" @default.
• W3202068700 startingPage "105197" @default.
• W3202068700 abstract "Intracerebral hemorrhage (ICH) is a devastating disease with high mortality and morbidity. Soluble epoxide hydrolase (sEH) is the key enzyme in the epoxyeicosatrienoic acids (EETs) signaling. sEH inhibition has been demonstrated to have neuroprotective effects against multiple brain injuries. However, its role in the secondary injuries after ICH has not been fully elucidated. Here we tested the hypothesis that 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), a potent and highly selective sEH inhibitor, suppresses inflammation and the secondary injuries after ICH. Adult male C57BL/6 mice were subjected to a collagenase-induced ICH model. TPPU alleviated blood-brain barrier damage, inhibited inflammatory response, increased M2 polarization of microglial cells, reduced the infiltration of peripheral neutrophils. In addition, TPPU attenuated neuronal injury and promoted functional recovery. The results suggest that sEH may represent a potential therapeutic target for the treatment of ICH." @default.
• W3202068700 created "2021-10-11" @default.
• W3202068700 creator A5020094986 @default.
• W3202068700 creator A5022558329 @default.
• W3202068700 creator A5023151599 @default.
• W3202068700 creator A5027734063 @default.
• W3202068700 creator A5028138849 @default.
• W3202068700 creator A5036820648 @default.
• W3202068700 creator A5044430936 @default.
• W3202068700 creator A5046597133 @default.
• W3202068700 creator A5068860104 @default.
• W3202068700 creator A5069585400 @default.
• W3202068700 date "2021-11-01" @default.
• W3202068700 modified "2023-09-26" @default.
• W3202068700 title "Soluble epoxide hydrolase inhibitor attenuates BBB disruption and neuroinflammation after intracerebral hemorrhage in mice" @default.
• W3202068700 cites W163988335 @default.
• W3202068700 cites W1917684854 @default.
• W3202068700 cites W1970131869 @default.
• W3202068700 cites W1971156281 @default.
• W3202068700 cites W1972223063 @default.
• W3202068700 cites W1975111111 @default.
• W3202068700 cites W1978379622 @default.
• W3202068700 cites W1987150492 @default.
• W3202068700 cites W1988340183 @default.
• W3202068700 cites W1992303064 @default.
• W3202068700 cites W1993788673 @default.
• W3202068700 cites W1996003447 @default.
• W3202068700 cites W1999982346 @default.
• W3202068700 cites W2001244796 @default.
• W3202068700 cites W2023520100 @default.
• W3202068700 cites W2043769668 @default.
• W3202068700 cites W2050913584 @default.
• W3202068700 cites W2064851917 @default.
• W3202068700 cites W2065971285 @default.
• W3202068700 cites W2073623008 @default.
• W3202068700 cites W2074906955 @default.
• W3202068700 cites W2078240600 @default.
• W3202068700 cites W2078824049 @default.
• W3202068700 cites W2079237158 @default.
• W3202068700 cites W2096567723 @default.
• W3202068700 cites W2097794078 @default.
• W3202068700 cites W2104567497 @default.
• W3202068700 cites W2106105150 @default.
• W3202068700 cites W2107277218 @default.
• W3202068700 cites W2110690814 @default.
• W3202068700 cites W2118695506 @default.
• W3202068700 cites W2124106343 @default.
• W3202068700 cites W2132862382 @default.
• W3202068700 cites W2149448669 @default.
• W3202068700 cites W2155567879 @default.
• W3202068700 cites W2159821105 @default.
• W3202068700 cites W2161631313 @default.
• W3202068700 cites W2163323735 @default.
• W3202068700 cites W2164884787 @default.
• W3202068700 cites W2166034362 @default.
• W3202068700 cites W2294419084 @default.
• W3202068700 cites W2297518964 @default.
• W3202068700 cites W2593130667 @default.
• W3202068700 cites W2606966917 @default.
• W3202068700 cites W2734025456 @default.
• W3202068700 cites W2743752916 @default.
• W3202068700 cites W2770711820 @default.
• W3202068700 cites W2806697406 @default.
• W3202068700 cites W2947622691 @default.
• W3202068700 cites W3112030344 @default.
• W3202068700 cites W4251400704 @default.
• W3202068700 doi "https://doi.org/10.1016/j.neuint.2021.105197" @default.
• W3202068700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34592333" @default.
• W3202068700 hasPublicationYear "2021" @default.
• W3202068700 type Work @default.
• W3202068700 sameAs 3202068700 @default.
• W3202068700 citedByCount "8" @default.
• W3202068700 countsByYear W32020687002022 @default.
• W3202068700 countsByYear W32020687002023 @default.
• W3202068700 crossrefType "journal-article" @default.
• W3202068700 hasAuthorship W3202068700A5020094986 @default.
• W3202068700 hasAuthorship W3202068700A5022558329 @default.
• W3202068700 hasAuthorship W3202068700A5023151599 @default.
• W3202068700 hasAuthorship W3202068700A5027734063 @default.
• W3202068700 hasAuthorship W3202068700A5028138849 @default.
• W3202068700 hasAuthorship W3202068700A5036820648 @default.
• W3202068700 hasAuthorship W3202068700A5044430936 @default.
• W3202068700 hasAuthorship W3202068700A5046597133 @default.
• W3202068700 hasAuthorship W3202068700A5068860104 @default.
• W3202068700 hasAuthorship W3202068700A5069585400 @default.
• W3202068700 hasConcept C181199279 @default.
• W3202068700 hasConcept C185592680 @default.
• W3202068700 hasConcept C18605011 @default.
• W3202068700 hasConcept C203014093 @default.
• W3202068700 hasConcept C25498285 @default.
• W3202068700 hasConcept C2776914184 @default.
• W3202068700 hasConcept C2777094939 @default.
• W3202068700 hasConcept C2777736543 @default.
• W3202068700 hasConcept C2778394429 @default.
• W3202068700 hasConcept C42219234 @default.
• W3202068700 hasConcept C55493867 @default.
• W3202068700 hasConcept C71924100 @default.
• W3202068700 hasConcept C87753298 @default.

• next