Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202070469> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3202070469 endingPage "9" @default.
- W3202070469 startingPage "1" @default.
- W3202070469 abstract "Aconitine is the main toxic component in aconite, a traditional Chinese medicine, which was widely used in emergency medicine. Aconitine is highly toxic, and a single dose of 0.2mg can cause malignant arrhythmiasdeath in adults. Early studies have shown that aconitine can improve arrhythmia in patients by affecting the calcium channel. The dual nature of aconitine therapy and toxicity is puzzling. While cardiac Ca2+ channel opening during repolarization has long been documented in normal human cardiac myocytes, the cellular effects and mechanism of ACO in Long QT syndrome patient remains unexplored. This study aimed to assess the proarrhythmic effects of ACO in healthy and Long QT syndrome patients with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). ACO concentration-dependently (0.05 ~ 5.0 ?M) decreased amplitude, which has no significant effect on cell index of normal hiPSC-CMs. While ACO 5.0 ?M decreased cell index between 5-30min for Long QT syndrome hiPSC-CMs. Meanwhile, ACO had no significant effect on the amplitude and frequency of calcium transients in normal cardiomyocytes, but it significantly increased the frequency of calcium transients in special cardiomyocytes of LQT disease at 5 ?M. Meanwhile, 0.05- 5 ?M ACO significantly shortened the action potential duration of human cardiomyocytes in both normal and LQT groups. Effect of ACO on L-type calcium current was detected in both normal hiPSC-CMs and LQTs hiPSC-CMs; it showed a similar blockage, which suggested that L-type calcium current may not be the major target on the effect of ACO on LQT disease. In conclusion, our data suggest that ACO had different effect on human cardiomyocytes in normal and LQT (hiPSC-CMs)." @default.
- W3202070469 created "2021-10-11" @default.
- W3202070469 creator A5001543788 @default.
- W3202070469 creator A5004072433 @default.
- W3202070469 creator A5012586166 @default.
- W3202070469 creator A5032741621 @default.
- W3202070469 creator A5038711316 @default.
- W3202070469 creator A5044832249 @default.
- W3202070469 creator A5068789691 @default.
- W3202070469 creator A5083330062 @default.
- W3202070469 date "2021-09-14" @default.
- W3202070469 modified "2023-09-24" @default.
- W3202070469 title "Different Proarrhythmic Effects of Aconitine on Healthy and Long QT Syndrome Patients with Human Pluripotent Stem Cell-Derived Cardiomyocytes" @default.
- W3202070469 doi "https://doi.org/10.31487/j.jso.2021.02.03" @default.
- W3202070469 hasPublicationYear "2021" @default.
- W3202070469 type Work @default.
- W3202070469 sameAs 3202070469 @default.
- W3202070469 citedByCount "0" @default.
- W3202070469 crossrefType "journal-article" @default.
- W3202070469 hasAuthorship W3202070469A5001543788 @default.
- W3202070469 hasAuthorship W3202070469A5004072433 @default.
- W3202070469 hasAuthorship W3202070469A5012586166 @default.
- W3202070469 hasAuthorship W3202070469A5032741621 @default.
- W3202070469 hasAuthorship W3202070469A5038711316 @default.
- W3202070469 hasAuthorship W3202070469A5044832249 @default.
- W3202070469 hasAuthorship W3202070469A5068789691 @default.
- W3202070469 hasAuthorship W3202070469A5083330062 @default.
- W3202070469 hasConcept C104317684 @default.
- W3202070469 hasConcept C107459253 @default.
- W3202070469 hasConcept C118441451 @default.
- W3202070469 hasConcept C126322002 @default.
- W3202070469 hasConcept C145103041 @default.
- W3202070469 hasConcept C146403970 @default.
- W3202070469 hasConcept C164705383 @default.
- W3202070469 hasConcept C185263204 @default.
- W3202070469 hasConcept C185592680 @default.
- W3202070469 hasConcept C2777547430 @default.
- W3202070469 hasConcept C2779703243 @default.
- W3202070469 hasConcept C42219234 @default.
- W3202070469 hasConcept C519063684 @default.
- W3202070469 hasConcept C55493867 @default.
- W3202070469 hasConcept C71924100 @default.
- W3202070469 hasConcept C85520022 @default.
- W3202070469 hasConcept C98274493 @default.
- W3202070469 hasConceptScore W3202070469C104317684 @default.
- W3202070469 hasConceptScore W3202070469C107459253 @default.
- W3202070469 hasConceptScore W3202070469C118441451 @default.
- W3202070469 hasConceptScore W3202070469C126322002 @default.
- W3202070469 hasConceptScore W3202070469C145103041 @default.
- W3202070469 hasConceptScore W3202070469C146403970 @default.
- W3202070469 hasConceptScore W3202070469C164705383 @default.
- W3202070469 hasConceptScore W3202070469C185263204 @default.
- W3202070469 hasConceptScore W3202070469C185592680 @default.
- W3202070469 hasConceptScore W3202070469C2777547430 @default.
- W3202070469 hasConceptScore W3202070469C2779703243 @default.
- W3202070469 hasConceptScore W3202070469C42219234 @default.
- W3202070469 hasConceptScore W3202070469C519063684 @default.
- W3202070469 hasConceptScore W3202070469C55493867 @default.
- W3202070469 hasConceptScore W3202070469C71924100 @default.
- W3202070469 hasConceptScore W3202070469C85520022 @default.
- W3202070469 hasConceptScore W3202070469C98274493 @default.
- W3202070469 hasIssue "2" @default.
- W3202070469 hasLocation W32020704691 @default.
- W3202070469 hasOpenAccess W3202070469 @default.
- W3202070469 hasPrimaryLocation W32020704691 @default.
- W3202070469 hasRelatedWork W1983098749 @default.
- W3202070469 hasRelatedWork W2094988844 @default.
- W3202070469 hasRelatedWork W2155235762 @default.
- W3202070469 hasRelatedWork W2274031004 @default.
- W3202070469 hasRelatedWork W2523026694 @default.
- W3202070469 hasRelatedWork W2538189119 @default.
- W3202070469 hasRelatedWork W2569997744 @default.
- W3202070469 hasRelatedWork W2735293439 @default.
- W3202070469 hasRelatedWork W2767259453 @default.
- W3202070469 hasRelatedWork W2909995258 @default.
- W3202070469 hasRelatedWork W2942633124 @default.
- W3202070469 hasRelatedWork W2970289864 @default.
- W3202070469 hasRelatedWork W2990214479 @default.
- W3202070469 hasRelatedWork W2999701079 @default.
- W3202070469 hasRelatedWork W3000576873 @default.
- W3202070469 hasRelatedWork W3045944213 @default.
- W3202070469 hasRelatedWork W3048030771 @default.
- W3202070469 hasRelatedWork W3095779261 @default.
- W3202070469 hasRelatedWork W3175765224 @default.
- W3202070469 hasRelatedWork W3193363978 @default.
- W3202070469 hasVolume "2021" @default.
- W3202070469 isParatext "false" @default.
- W3202070469 isRetracted "false" @default.
- W3202070469 magId "3202070469" @default.
- W3202070469 workType "article" @default.