Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202080311> ?p ?o ?g. }
- W3202080311 endingPage "101137" @default.
- W3202080311 startingPage "101137" @default.
- W3202080311 abstract "As both anabolic and anti-catabolic osteoporosis drugs affect bone formation and resorption processes, they may contribute to bone's overall mechanical behavior by altering the quality of the bone matrix. We used an ovariectomized rat model and a novel fracture mechanics approach to investigate whether treatment with an anabolic (parathyroid hormone) or anti-catabolic (alendronate) osteoporosis drugs will alter the organic and mineral matrix components and consequently cortical bone fracture toughness. Ovariectomized (at 5 months age) rats were treated with either parathyroid hormone or alendronate at low and high doses for 6 months (age 6-12 months). Specifically, treatment groups included untreated ovariectomized controls (n = 9), high-dose alendronate (n = 10), low-dose alendronate (n = 9), high-dose parathyroid hormone (n = 10), and low-dose parathyroid hormone (n = 9). After euthanasia, cortical microbeams from the lateral quadrant were extracted, notched, and tested in 3-point bending to measure fracture toughness. Portions of the bone were used to measure changes in the 1) organic matrix through quantification of advanced glycation end-products (AGEs) and non-collagenous proteins, and 2) mineral matrix through assessment of mineral crystallinity. Compared to the ovariectomized group, rats treated with high doses of parathyroid hormone and alendronate had significantly increased cortical bone fracture toughness, which corresponded primarily to increased non-collagenous proteins while there was no change in AGEs. Additionally, low-dose PTH treatment increased matrix crystallinity and decreased AGE levels. In summary, ovariectomized rats treated with pharmaceutical drugs had increased non-collagenous matrix proteins and improved fracture toughness compared to controls. Further investigation is required for different doses and longer treatment periods." @default.
- W3202080311 created "2021-10-11" @default.
- W3202080311 creator A5010309135 @default.
- W3202080311 creator A5012957590 @default.
- W3202080311 creator A5090010894 @default.
- W3202080311 creator A5091765205 @default.
- W3202080311 date "2021-12-01" @default.
- W3202080311 modified "2023-10-14" @default.
- W3202080311 title "Dose-dependent effects of pharmaceutical treatments on bone matrix properties in ovariectomized rats" @default.
- W3202080311 cites W1526826623 @default.
- W3202080311 cites W1964755289 @default.
- W3202080311 cites W1971589882 @default.
- W3202080311 cites W1977387775 @default.
- W3202080311 cites W1978064775 @default.
- W3202080311 cites W1979577268 @default.
- W3202080311 cites W1990900083 @default.
- W3202080311 cites W1993798820 @default.
- W3202080311 cites W1994669017 @default.
- W3202080311 cites W1994925559 @default.
- W3202080311 cites W1997697459 @default.
- W3202080311 cites W1999609152 @default.
- W3202080311 cites W2001018521 @default.
- W3202080311 cites W2001957914 @default.
- W3202080311 cites W2003158379 @default.
- W3202080311 cites W2005298224 @default.
- W3202080311 cites W2006021879 @default.
- W3202080311 cites W2009827512 @default.
- W3202080311 cites W2010110993 @default.
- W3202080311 cites W2010486222 @default.
- W3202080311 cites W2019076654 @default.
- W3202080311 cites W2022836308 @default.
- W3202080311 cites W2024039650 @default.
- W3202080311 cites W2031120011 @default.
- W3202080311 cites W2032137351 @default.
- W3202080311 cites W2034374758 @default.
- W3202080311 cites W2034569221 @default.
- W3202080311 cites W2038544875 @default.
- W3202080311 cites W2038643948 @default.
- W3202080311 cites W2038989154 @default.
- W3202080311 cites W2039192398 @default.
- W3202080311 cites W2040502312 @default.
- W3202080311 cites W2041059512 @default.
- W3202080311 cites W2045775029 @default.
- W3202080311 cites W2049109419 @default.
- W3202080311 cites W2049177176 @default.
- W3202080311 cites W2052991153 @default.
- W3202080311 cites W2055161650 @default.
- W3202080311 cites W2055438866 @default.
- W3202080311 cites W2059527919 @default.
- W3202080311 cites W2060139149 @default.
- W3202080311 cites W2060678541 @default.
- W3202080311 cites W2061235833 @default.
- W3202080311 cites W2068394273 @default.
- W3202080311 cites W2069641334 @default.
- W3202080311 cites W2073269056 @default.
- W3202080311 cites W2079787452 @default.
- W3202080311 cites W2081510905 @default.
- W3202080311 cites W2082331691 @default.
- W3202080311 cites W2086732436 @default.
- W3202080311 cites W2088071453 @default.
- W3202080311 cites W2088588903 @default.
- W3202080311 cites W2088798468 @default.
- W3202080311 cites W2095822930 @default.
- W3202080311 cites W2101680622 @default.
- W3202080311 cites W2104717775 @default.
- W3202080311 cites W2105091019 @default.
- W3202080311 cites W2113920448 @default.
- W3202080311 cites W2114528551 @default.
- W3202080311 cites W2117729857 @default.
- W3202080311 cites W2120395513 @default.
- W3202080311 cites W2135031212 @default.
- W3202080311 cites W2141235584 @default.
- W3202080311 cites W2142608062 @default.
- W3202080311 cites W2143214738 @default.
- W3202080311 cites W2144578072 @default.
- W3202080311 cites W2144971094 @default.
- W3202080311 cites W2149414710 @default.
- W3202080311 cites W2151147342 @default.
- W3202080311 cites W2155728216 @default.
- W3202080311 cites W2155977502 @default.
- W3202080311 cites W2161837912 @default.
- W3202080311 cites W2162212747 @default.
- W3202080311 cites W2162767896 @default.
- W3202080311 cites W2168684642 @default.
- W3202080311 cites W2173023862 @default.
- W3202080311 cites W2335178464 @default.
- W3202080311 cites W2396480763 @default.
- W3202080311 cites W2414866503 @default.
- W3202080311 cites W2544386575 @default.
- W3202080311 cites W2569948192 @default.
- W3202080311 cites W2684151745 @default.
- W3202080311 cites W2751856605 @default.
- W3202080311 cites W2765365236 @default.
- W3202080311 cites W2780378596 @default.
- W3202080311 cites W2784148496 @default.
- W3202080311 cites W2805127489 @default.
- W3202080311 cites W2888794195 @default.
- W3202080311 cites W2921427704 @default.