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• W3202086196 endingPage "10604" @default.
• W3202086196 startingPage "10604" @default.
• W3202086196 abstract "Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. An accumulation of fat, followed by inflammation, is the major cause of NAFLD progression. During inflammation, macrophages are the most abundant immune cells recruited to the site of injury. Macrophages are classified into proinflammatory M1 macrophages, and anti-inflammatory M2 macrophages. In NAFLD, M1 macrophages are the most prominent macrophages that lead to an excessive inflammatory response. Previously, we found that baicalin could polarize macrophages into anti-inflammatory M2c subtype macrophages with an increased level of MERTK expression. Several studies have also shown a strong correlation between MERTK expression and cholesterol efflux, efferocytosis, as well as phagocytosis capability. Therefore, in this study, we aim to elucidate the potential and efficacy of mononuclear-cell (MNC)-derived MERTK+/hi M2c macrophages induced by baicalin as a cell-based therapy for NAFLD treatment. In our results, we have demonstrated that a MERTK+/hi M2c macrophage injection to NAFLD mice contributes to an increased level of serum HDL secretion in the liver, a decline in the circulating CD4+CD25- and CD8+CD25- T cells and lowers the total NAFLD pathological score by lessening the inflammation, necrosis, and fibrosis. In the liver, profibrotic COL1A1 and FN, proinflammation TNFα, as well as the regulator of lipid metabolism PPARɣ expression, were also downregulated after injection. In parallel, the transcriptomic profiles of the injected MERTK+/hi M2c macrophages showed that the various genes directly or indirectly involved in NAFLD progression (e.g., SERPINE1, FADS2) were also suppressed. Downregulation of cytokines and inflammation-associated genes, such as CCR5, may promote a pro-resolving milieu in the NAFLD liver. Altogether, cell-based therapy using MERTK+/hi M2c macrophages is promising, as it ameliorates NAFLD in mice." @default.
• W3202086196 created "2021-10-11" @default.
• W3202086196 creator A5005797679 @default.
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• W3202086196 creator A5088357055 @default.
• W3202086196 date "2021-09-30" @default.
• W3202086196 modified "2023-10-15" @default.
• W3202086196 title "MERTK+/hi M2c Macrophages Induced by Baicalin Alleviate Non-Alcoholic Fatty Liver Disease" @default.
• W3202086196 cites W1518095394 @default.
• W3202086196 cites W1856581299 @default.
• W3202086196 cites W1932245698 @default.
• W3202086196 cites W1973271532 @default.
• W3202086196 cites W1975705605 @default.
• W3202086196 cites W1976137269 @default.
• W3202086196 cites W1978888457 @default.
• W3202086196 cites W1985333297 @default.
• W3202086196 cites W1988128873 @default.
• W3202086196 cites W1990679071 @default.
• W3202086196 cites W2007322776 @default.
• W3202086196 cites W2009170266 @default.
• W3202086196 cites W2014980326 @default.
• W3202086196 cites W2021032684 @default.
• W3202086196 cites W2025751643 @default.
• W3202086196 cites W2027995863 @default.
• W3202086196 cites W2035500547 @default.
• W3202086196 cites W2037618281 @default.
• W3202086196 cites W2055347368 @default.
• W3202086196 cites W2065210647 @default.
• W3202086196 cites W2067740038 @default.
• W3202086196 cites W2070855360 @default.
• W3202086196 cites W2078176020 @default.
• W3202086196 cites W2082581904 @default.
• W3202086196 cites W2119305519 @default.
• W3202086196 cites W2119710439 @default.
• W3202086196 cites W2120805022 @default.
• W3202086196 cites W2129935236 @default.
• W3202086196 cites W2130892442 @default.
• W3202086196 cites W2137507114 @default.
• W3202086196 cites W2138915349 @default.
• W3202086196 cites W2139560266 @default.
• W3202086196 cites W2144741217 @default.
• W3202086196 cites W2161241326 @default.
• W3202086196 cites W2162943945 @default.
• W3202086196 cites W2194821962 @default.
• W3202086196 cites W2204688218 @default.
• W3202086196 cites W2257297310 @default.
• W3202086196 cites W2339396273 @default.
• W3202086196 cites W2343328570 @default.
• W3202086196 cites W2549973686 @default.
• W3202086196 cites W2557792283 @default.
• W3202086196 cites W2561860468 @default.
• W3202086196 cites W2581434358 @default.
• W3202086196 cites W2609217537 @default.
• W3202086196 cites W2734941977 @default.
• W3202086196 cites W2744435745 @default.
• W3202086196 cites W2744982526 @default.
• W3202086196 cites W2750908099 @default.
• W3202086196 cites W2755181058 @default.
• W3202086196 cites W2774239498 @default.
• W3202086196 cites W2777780841 @default.
• W3202086196 cites W2783733493 @default.
• W3202086196 cites W2794639926 @default.
• W3202086196 cites W2810423511 @default.
• W3202086196 cites W2883933276 @default.
• W3202086196 cites W2892128815 @default.
• W3202086196 cites W2893194863 @default.
• W3202086196 cites W2893769734 @default.
• W3202086196 cites W2895618137 @default.
• W3202086196 cites W2902488887 @default.
• W3202086196 cites W2905827542 @default.
• W3202086196 cites W2910914574 @default.
• W3202086196 cites W2911661905 @default.
• W3202086196 cites W2913088743 @default.
• W3202086196 cites W2914051549 @default.
• W3202086196 cites W2918648125 @default.
• W3202086196 cites W2946942881 @default.
• W3202086196 cites W2955084980 @default.
• W3202086196 cites W2992508842 @default.
• W3202086196 cites W2995961563 @default.
• W3202086196 cites W3003879561 @default.
• W3202086196 cites W3012144395 @default.
• W3202086196 cites W3016403534 @default.
• W3202086196 cites W3016423213 @default.
• W3202086196 cites W3081735976 @default.
• W3202086196 cites W3083417520 @default.
• W3202086196 cites W3093798436 @default.
• W3202086196 cites W4241721607 @default.
• W3202086196 cites W4242114161 @default.
• W3202086196 cites W4244189832 @default.
• W3202086196 cites W4313368444 @default.
• W3202086196 cites W90736706 @default.
• W3202086196 doi "https://doi.org/10.3390/ijms221910604" @default.
• W3202086196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508959" @default.
• W3202086196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34638941" @default.
• W3202086196 hasPublicationYear "2021" @default.
• W3202086196 type Work @default.

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