Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202097872> ?p ?o ?g. }
- W3202097872 endingPage "451" @default.
- W3202097872 startingPage "439" @default.
- W3202097872 abstract "The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia, or other erythropoietic stimuli, and it suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis. Suppression of hepcidin by ERFE is believed to be mediated by interference with paracrine bone morphogenetic protein (BMP) signaling that regulates hepcidin transcription in hepatocytes. In anemias with ineffective erythropoiesis, ERFE is pathologically overproduced, but its contribution to the clinical manifestations of these anemias is not well understood. We generated 3 lines of transgenic mice with graded erythroid overexpression of ERFE and found that they developed dose-dependent iron overload, impaired hepatic BMP signaling, and relative hepcidin deficiency. These findings add to the evidence that ERFE is a mediator of iron overload in conditions in which ERFE is overproduced, including anemias with ineffective erythropoiesis. At the highest levels of ERFE overexpression, the mice manifested decreased perinatal survival, impaired growth, small hypofunctional kidneys, decreased gonadal fat depots, and neurobehavioral abnormalities, all consistent with impaired organ-specific BMP signaling during development. Neutralizing excessive ERFE in congenital anemias with ineffective erythropoiesis may not only prevent iron overload but may have additional benefits for growth and development." @default.
- W3202097872 created "2021-10-11" @default.
- W3202097872 creator A5005224360 @default.
- W3202097872 creator A5009550691 @default.
- W3202097872 creator A5010751682 @default.
- W3202097872 creator A5028919896 @default.
- W3202097872 creator A5035815172 @default.
- W3202097872 creator A5036220506 @default.
- W3202097872 creator A5083215813 @default.
- W3202097872 date "2022-01-20" @default.
- W3202097872 modified "2023-10-18" @default.
- W3202097872 title "Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice" @default.
- W3202097872 cites W1844334486 @default.
- W3202097872 cites W1966227201 @default.
- W3202097872 cites W1970714562 @default.
- W3202097872 cites W1973313690 @default.
- W3202097872 cites W1977840583 @default.
- W3202097872 cites W1980042430 @default.
- W3202097872 cites W1980584303 @default.
- W3202097872 cites W1992083687 @default.
- W3202097872 cites W1993817188 @default.
- W3202097872 cites W1994960912 @default.
- W3202097872 cites W2001570896 @default.
- W3202097872 cites W2002549547 @default.
- W3202097872 cites W2006046265 @default.
- W3202097872 cites W2007440356 @default.
- W3202097872 cites W2019353901 @default.
- W3202097872 cites W2035000551 @default.
- W3202097872 cites W2038731528 @default.
- W3202097872 cites W2041745288 @default.
- W3202097872 cites W2042924761 @default.
- W3202097872 cites W2056437480 @default.
- W3202097872 cites W2057837809 @default.
- W3202097872 cites W2076005089 @default.
- W3202097872 cites W2077789375 @default.
- W3202097872 cites W2086284653 @default.
- W3202097872 cites W2091952666 @default.
- W3202097872 cites W2111879337 @default.
- W3202097872 cites W2114245705 @default.
- W3202097872 cites W2119493074 @default.
- W3202097872 cites W2123618247 @default.
- W3202097872 cites W2124415162 @default.
- W3202097872 cites W2148245224 @default.
- W3202097872 cites W2150582334 @default.
- W3202097872 cites W2150673679 @default.
- W3202097872 cites W2160016772 @default.
- W3202097872 cites W2161195938 @default.
- W3202097872 cites W2161653019 @default.
- W3202097872 cites W2163438420 @default.
- W3202097872 cites W2165213969 @default.
- W3202097872 cites W2166920557 @default.
- W3202097872 cites W2168905961 @default.
- W3202097872 cites W2401643476 @default.
- W3202097872 cites W2468407430 @default.
- W3202097872 cites W2510535325 @default.
- W3202097872 cites W2554256852 @default.
- W3202097872 cites W2557067290 @default.
- W3202097872 cites W2559408993 @default.
- W3202097872 cites W2569623121 @default.
- W3202097872 cites W2738794292 @default.
- W3202097872 cites W2887425495 @default.
- W3202097872 cites W2896431818 @default.
- W3202097872 cites W2901029372 @default.
- W3202097872 cites W2903168130 @default.
- W3202097872 cites W2926799971 @default.
- W3202097872 cites W2936956362 @default.
- W3202097872 cites W2940313036 @default.
- W3202097872 cites W2963138219 @default.
- W3202097872 cites W2963530933 @default.
- W3202097872 cites W2969178073 @default.
- W3202097872 cites W2978376971 @default.
- W3202097872 cites W2984856645 @default.
- W3202097872 cites W2990952455 @default.
- W3202097872 cites W2992044710 @default.
- W3202097872 cites W2994665347 @default.
- W3202097872 cites W3000240243 @default.
- W3202097872 cites W3043944100 @default.
- W3202097872 cites W3044453110 @default.
- W3202097872 cites W3195055049 @default.
- W3202097872 cites W4211119300 @default.
- W3202097872 doi "https://doi.org/10.1182/blood.2021014054" @default.
- W3202097872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34614145" @default.
- W3202097872 hasPublicationYear "2022" @default.
- W3202097872 type Work @default.
- W3202097872 sameAs 3202097872 @default.
- W3202097872 citedByCount "15" @default.
- W3202097872 countsByYear W32020978722022 @default.
- W3202097872 countsByYear W32020978722023 @default.
- W3202097872 crossrefType "journal-article" @default.
- W3202097872 hasAuthorship W3202097872A5005224360 @default.
- W3202097872 hasAuthorship W3202097872A5009550691 @default.
- W3202097872 hasAuthorship W3202097872A5010751682 @default.
- W3202097872 hasAuthorship W3202097872A5028919896 @default.
- W3202097872 hasAuthorship W3202097872A5035815172 @default.
- W3202097872 hasAuthorship W3202097872A5036220506 @default.
- W3202097872 hasAuthorship W3202097872A5083215813 @default.
- W3202097872 hasBestOaLocation W32020978721 @default.
- W3202097872 hasConcept C126322002 @default.