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- W3202101113 abstract "Suicide in Bipolar Disorder (BD) is a relevant clinical concern. Genetics may shape the individual risk for suicide behavior in BD, together with known clinical factors. The lack of consistent replication in BD may be associated with its multigenetic component. In the present contribution we analyzed a sample of BD individuals (from STEP-BD database) to identify the genetic variants potentially associated with three different suicide-related phenotypes: (1) a feeling that the life was not worth living; (2) fantasies about committing a violent suicide; (3) previous attempted suicide. The sample under analysis included 1115 BD individuals. None of the SNPs reached genome-wide significance. However, a trend of association was evidenced for rs2767403, an intron variant of AOPEP gene, in association with phenotype #1 (p = 5.977 × 10-6). The molecular pathway analysis showed a significant enrichment in all the investigated phenotypes on pathways related to post synaptic signaling, neurotransmission and neurodevelopment. Further, NOTCH signaling or the γ-aminobutyric acid (GABA)-ergic signaling were found to be associated with specific suicide-related phenotypes. The present investigation contributes to the hypothesis that the genetic architecture of suicide behaviors in BD is related to alteration of entire pathways rather than single genes. In particular, our molecular pathway analysis points on some specific molecular events that could be the focus of further research in this field." @default.
- W3202101113 created "2021-10-11" @default.
- W3202101113 creator A5007893733 @default.
- W3202101113 creator A5059524154 @default.
- W3202101113 creator A5078543315 @default.
- W3202101113 creator A5085449546 @default.
- W3202101113 creator A5087144393 @default.
- W3202101113 date "2021-09-23" @default.
- W3202101113 modified "2023-10-18" @default.
- W3202101113 title "Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings" @default.
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