Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202103635> ?p ?o ?g. }
- W3202103635 abstract "Selectively inducing lysosomal membrane permeabilization (LMP) is a promising strategy for cancer therapy. But integrating alkaline phosphatase (ALP)-instructed self-assembly and lysosome-targeting to induce LMP for selective killing of cancer cells was not reported. Herein, a pyrene-peptide conjugate Py-Phe-Phe-Glu-Tyr(H2 PO3 )-Gly-lyso (Py-Yp-Lyso) is rationally designed and demonstrated for its lysosome-targeting cytotoxicity on cancer cells, together with its pyrene (Py) excimer fluorescence turning on at 480 nm. In vitro results showed that, Py-Yp-Lyso is efficiently dephosphorylated by ALP to yield Py-Phe-Phe-Glu-Tyr-Gly-lyso (Py-Y-Lyso) which self-assembles into nanofibers. Cell experiments verified that, after being taken up by HeLa cells, the excimer fluorescence of Py-Yp-Lyso assemblies has turned on and the assemblies specifically target the lysosomes, inducing LMP and ultimate cancer cell death. In vivo experiments indicated that Py-Yp-Lyso has the highest inhibition effect on HeLa tumors among the four compounds studied. This is anticipated for applying Py-Yp-Lyso to treat cancers in the clinic in the future." @default.
- W3202103635 created "2021-10-11" @default.
- W3202103635 creator A5014081936 @default.
- W3202103635 creator A5023764156 @default.
- W3202103635 creator A5029322489 @default.
- W3202103635 creator A5029765615 @default.
- W3202103635 creator A5037709424 @default.
- W3202103635 creator A5043174255 @default.
- W3202103635 creator A5055694167 @default.
- W3202103635 creator A5061541067 @default.
- W3202103635 creator A5089079624 @default.
- W3202103635 date "2021-10-23" @default.
- W3202103635 modified "2023-10-14" @default.
- W3202103635 title "Lysosome‐Targeted and Fluorescence‐Turned “On” Cytotoxicity Induced by Alkaline Phosphatase‐Triggered Self‐Assembly" @default.
- W3202103635 cites W1538419182 @default.
- W3202103635 cites W1964083798 @default.
- W3202103635 cites W1966803171 @default.
- W3202103635 cites W1968652809 @default.
- W3202103635 cites W1970661950 @default.
- W3202103635 cites W1974222323 @default.
- W3202103635 cites W1987619840 @default.
- W3202103635 cites W1994980982 @default.
- W3202103635 cites W2003447206 @default.
- W3202103635 cites W2030017878 @default.
- W3202103635 cites W2041581075 @default.
- W3202103635 cites W2049288477 @default.
- W3202103635 cites W2055324972 @default.
- W3202103635 cites W2080878773 @default.
- W3202103635 cites W2094439964 @default.
- W3202103635 cites W2094898345 @default.
- W3202103635 cites W2095893897 @default.
- W3202103635 cites W2101782398 @default.
- W3202103635 cites W2103742020 @default.
- W3202103635 cites W2117692326 @default.
- W3202103635 cites W2120190080 @default.
- W3202103635 cites W2123105952 @default.
- W3202103635 cites W2139333712 @default.
- W3202103635 cites W2144917539 @default.
- W3202103635 cites W2147328441 @default.
- W3202103635 cites W2156179144 @default.
- W3202103635 cites W2180008421 @default.
- W3202103635 cites W2314046004 @default.
- W3202103635 cites W2321818080 @default.
- W3202103635 cites W2325622903 @default.
- W3202103635 cites W2330860594 @default.
- W3202103635 cites W2510252434 @default.
- W3202103635 cites W2516305941 @default.
- W3202103635 cites W2549641338 @default.
- W3202103635 cites W2562103780 @default.
- W3202103635 cites W2570618306 @default.
- W3202103635 cites W2619181032 @default.
- W3202103635 cites W2731353557 @default.
- W3202103635 cites W2778064163 @default.
- W3202103635 cites W2781525129 @default.
- W3202103635 cites W2789162174 @default.
- W3202103635 cites W2795821736 @default.
- W3202103635 cites W2810093943 @default.
- W3202103635 cites W2823865577 @default.
- W3202103635 cites W2885202191 @default.
- W3202103635 cites W2888292224 @default.
- W3202103635 cites W2902449173 @default.
- W3202103635 cites W2938678031 @default.
- W3202103635 cites W3010720285 @default.
- W3202103635 cites W3012497599 @default.
- W3202103635 doi "https://doi.org/10.1002/adhm.202101346" @default.
- W3202103635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34624168" @default.
- W3202103635 hasPublicationYear "2021" @default.
- W3202103635 type Work @default.
- W3202103635 sameAs 3202103635 @default.
- W3202103635 citedByCount "14" @default.
- W3202103635 countsByYear W32021036352022 @default.
- W3202103635 countsByYear W32021036352023 @default.
- W3202103635 crossrefType "journal-article" @default.
- W3202103635 hasAuthorship W3202103635A5014081936 @default.
- W3202103635 hasAuthorship W3202103635A5023764156 @default.
- W3202103635 hasAuthorship W3202103635A5029322489 @default.
- W3202103635 hasAuthorship W3202103635A5029765615 @default.
- W3202103635 hasAuthorship W3202103635A5037709424 @default.
- W3202103635 hasAuthorship W3202103635A5043174255 @default.
- W3202103635 hasAuthorship W3202103635A5055694167 @default.
- W3202103635 hasAuthorship W3202103635A5061541067 @default.
- W3202103635 hasAuthorship W3202103635A5089079624 @default.
- W3202103635 hasConcept C109316439 @default.
- W3202103635 hasConcept C119599485 @default.
- W3202103635 hasConcept C121608353 @default.
- W3202103635 hasConcept C12554922 @default.
- W3202103635 hasConcept C127413603 @default.
- W3202103635 hasConcept C153911025 @default.
- W3202103635 hasConcept C160160445 @default.
- W3202103635 hasConcept C161694136 @default.
- W3202103635 hasConcept C178790620 @default.
- W3202103635 hasConcept C181199279 @default.
- W3202103635 hasConcept C185592680 @default.
- W3202103635 hasConcept C202751555 @default.
- W3202103635 hasConcept C2777366897 @default.
- W3202103635 hasConcept C2778951431 @default.
- W3202103635 hasConcept C2780216420 @default.
- W3202103635 hasConcept C2780330291 @default.
- W3202103635 hasConcept C54355233 @default.
- W3202103635 hasConcept C55493867 @default.