FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202112312> ?p ?o ?g. }

• W3202112312 endingPage "394" @default.
• W3202112312 startingPage "387" @default.
• W3202112312 abstract "Valproic acid (VPA) is widely used antiepileptic agent which is associated with reproductive toxicity via impairment in oxidative redox. Zinc (Zn) and selenium (Se) are trace element with antioxidant effect that known to be essential for spermatogenesis. In the current study, the protective effect of co-administration of Zn and Se on VPA-induced reproductive toxicity in male rats was evaluated. Forty-eight male rats were divided into 8 groups of six (n=6): Control group (treated with normal saline); VPA only (250, 500, 1,000 mg/kg) group; VPA (500 mg/kg) plus Zn (2 mg/kg) group; VPA (500 mg/kg) plus Se (1.5 mg/kg) group; VPA (500 mg/kg) plus a combination of Zn and Se group; and VPA+vitamin E (20 mg/kg) group. The Animals were sacrificed after 28 days of treatment and sperm analysis was taken. Also, evaluation of oxidative stress markers including malondialdehyde (MDA), protein carbonyl (PC), glutathione (GSH) and histopathological changes were done on testis tissue. Morphological changes and a significant decrease in motility and sperm count in rats treated with VPA were observed. Also, an increase in oxidative stress marker, including MDA and PC and a decrease in GSH level was evident in VPA group. Zn and Se administration was able to protect against sperm abnormality, ameliorate the histological change in testis tissue, and suppressed the increase in oxidative stress markers induced by VPA. These results indicated that combination therapy with Zn and Se showed better an ameliorative effect than each one alone. Therefore, it can be suggested as an effective supplement for reproductive impairment in VPA-treated patient." @default.
• W3202112312 created "2021-10-11" @default.
• W3202112312 creator A5037363208 @default.
• W3202112312 creator A5037484184 @default.
• W3202112312 creator A5040835677 @default.
• W3202112312 creator A5066988916 @default.
• W3202112312 creator A5072237360 @default.
• W3202112312 date "2021-09-30" @default.
• W3202112312 modified "2023-10-02" @default.
• W3202112312 title "Zinc and selenium supplement mitigated valproic acid-induced testis toxicity by modulating the oxidative redox balance in male rats" @default.
• W3202112312 cites W1902073326 @default.
• W3202112312 cites W1968650667 @default.
• W3202112312 cites W1977820005 @default.
• W3202112312 cites W1991378187 @default.
• W3202112312 cites W1997730701 @default.
• W3202112312 cites W1998166648 @default.
• W3202112312 cites W2005568203 @default.
• W3202112312 cites W2008317657 @default.
• W3202112312 cites W2019379404 @default.
• W3202112312 cites W2026793455 @default.
• W3202112312 cites W2037853089 @default.
• W3202112312 cites W2039422123 @default.
• W3202112312 cites W2040017850 @default.
• W3202112312 cites W2046816983 @default.
• W3202112312 cites W2056820430 @default.
• W3202112312 cites W2057926527 @default.
• W3202112312 cites W2059643569 @default.
• W3202112312 cites W2072898133 @default.
• W3202112312 cites W2077424997 @default.
• W3202112312 cites W2080083224 @default.
• W3202112312 cites W2080360017 @default.
• W3202112312 cites W2081280838 @default.
• W3202112312 cites W2089313341 @default.
• W3202112312 cites W2091124986 @default.
• W3202112312 cites W2096978851 @default.
• W3202112312 cites W2102948634 @default.
• W3202112312 cites W2102986728 @default.
• W3202112312 cites W2118480693 @default.
• W3202112312 cites W2161111071 @default.
• W3202112312 cites W2165201727 @default.
• W3202112312 cites W2168801847 @default.
• W3202112312 cites W2262094736 @default.
• W3202112312 cites W2466516086 @default.
• W3202112312 cites W2580704725 @default.
• W3202112312 doi "https://doi.org/10.5115/acb.20.280" @default.
• W3202112312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8493015" @default.
• W3202112312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34588319" @default.
• W3202112312 hasPublicationYear "2021" @default.
• W3202112312 type Work @default.
• W3202112312 sameAs 3202112312 @default.
• W3202112312 citedByCount "2" @default.
• W3202112312 countsByYear W32021123122023 @default.
• W3202112312 crossrefType "journal-article" @default.
• W3202112312 hasAuthorship W3202112312A5037363208 @default.
• W3202112312 hasAuthorship W3202112312A5037484184 @default.
• W3202112312 hasAuthorship W3202112312A5040835677 @default.
• W3202112312 hasAuthorship W3202112312A5066988916 @default.
• W3202112312 hasAuthorship W3202112312A5072237360 @default.
• W3202112312 hasBestOaLocation W32021123121 @default.
• W3202112312 hasConcept C126322002 @default.
• W3202112312 hasConcept C168031717 @default.
• W3202112312 hasConcept C169760540 @default.
• W3202112312 hasConcept C178790620 @default.
• W3202112312 hasConcept C179104552 @default.
• W3202112312 hasConcept C185592680 @default.
• W3202112312 hasConcept C2776151105 @default.
• W3202112312 hasConcept C2777172819 @default.
• W3202112312 hasConcept C2778186239 @default.
• W3202112312 hasConcept C29730261 @default.
• W3202112312 hasConcept C33070731 @default.
• W3202112312 hasConcept C535196362 @default.
• W3202112312 hasConcept C553756173 @default.
• W3202112312 hasConcept C55493867 @default.
• W3202112312 hasConcept C55904794 @default.
• W3202112312 hasConcept C57600042 @default.
• W3202112312 hasConcept C71924100 @default.
• W3202112312 hasConcept C86803240 @default.
• W3202112312 hasConcept C98274493 @default.
• W3202112312 hasConceptScore W3202112312C126322002 @default.
• W3202112312 hasConceptScore W3202112312C168031717 @default.
• W3202112312 hasConceptScore W3202112312C169760540 @default.
• W3202112312 hasConceptScore W3202112312C178790620 @default.
• W3202112312 hasConceptScore W3202112312C179104552 @default.
• W3202112312 hasConceptScore W3202112312C185592680 @default.
• W3202112312 hasConceptScore W3202112312C2776151105 @default.
• W3202112312 hasConceptScore W3202112312C2777172819 @default.
• W3202112312 hasConceptScore W3202112312C2778186239 @default.
• W3202112312 hasConceptScore W3202112312C29730261 @default.
• W3202112312 hasConceptScore W3202112312C33070731 @default.
• W3202112312 hasConceptScore W3202112312C535196362 @default.
• W3202112312 hasConceptScore W3202112312C553756173 @default.
• W3202112312 hasConceptScore W3202112312C55493867 @default.
• W3202112312 hasConceptScore W3202112312C55904794 @default.
• W3202112312 hasConceptScore W3202112312C57600042 @default.
• W3202112312 hasConceptScore W3202112312C71924100 @default.
• W3202112312 hasConceptScore W3202112312C86803240 @default.
• W3202112312 hasConceptScore W3202112312C98274493 @default.
• W3202112312 hasIssue "3" @default.

• next