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- W3202142733 abstract "Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by foreign and host molecules in order to initiate the immune response. They play a crucial role in the regulation of innate immunity, and several studies have shown their importance in bacterial, viral, and fungal infections, autoimmune diseases, and cancers. The consensus view from an immunological perspective is that TLR agonists can serve either as a possible therapeutic agent or as a vaccine adjuvant toward cancers or infectious diseases and that TLR inhibitors may be a promising approach to the treatment of autoimmune diseases, some cancers, bacterial, and viral infections. These notions are based on the fact that TLR agonists stimulate the secretion of proinflammatory cytokines and in general, the development of proinflammatory responses. Some of the TLR-based inhibitory agents have shown to be efficacious in preclinical models and have now entered clinical trials. Therefore, TLRs seem to hold the potential to serve as a perfect target in the era of immunotherapies. We offer a perspective on TLR-based therapeutics that sheds light on their usefulness and on combination therapies. We also highlight various therapeutics that are in the discovery phase or in clinical trials." @default.
- W3202142733 created "2021-10-11" @default.
- W3202142733 creator A5000545845 @default.
- W3202142733 creator A5020674417 @default.
- W3202142733 creator A5050679596 @default.
- W3202142733 creator A5072408448 @default.
- W3202142733 date "2021-10-04" @default.
- W3202142733 modified "2023-10-15" @default.
- W3202142733 title "Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies" @default.
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