FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202198997> ?p ?o ?g. }

• W3202198997 abstract "Abstract Background: Pytoproptosis has been verified to participate in various malignancies. However, studies on pyroptosis-related lncRNAs in breast cancer and its effects on tumor immune micro-environment are still limited. Consequently, it was aimed in this study to construct a pyroptosis-related lncRNAs signature for prognostic prediction and explore the effect of the pyroptosis-related LncRNAs on tumor immune microenvironment through LncRNA-miRNA-mRNA regulatory network. Methods: The pyroptosis-related differentially expressed genes (DEGs) were discovered using differential expression analysis. The differentially expressed LncRNAs (DELncRNAs) associated with DEGs were discovered using correlation analysis. The function of DEGs was analyed using GO and KEGG analyses. The LncRNAs signature used as the prognostic model of breast cancer was constructed using univariate and multivariate Cox analysis, and the effectiveness was verified by K-M analysis and ROC curve. The risk score calculated using the prognostic model was proved as an independent factor by univariate Cox analysis, multivariate Cox analysis and PCA analysis, and used to predict patient prognosis through nomogram. The pathyways enriched in High risk group and Low risk group were analyzed by GSEA. The differences in immune cell distribution (B cell memory, T cell CD4+, T cell CD8+ among others) were analyzed using ssGSEA. The immune function (type I/II IFN response among others), immune checkpoint (ADORA2A among others) and m6A-related protein expression (FTO among others) of High risk group and Low risk group were compared. The regulatory network of pyroptosis-related LncRNA-miRNA-mRNA was constructed and the core network was extracted. The functions of the target genes of miRNA associated with DELncRNAs were explored using GO and KEGG analysis. Results: A 9 LncRNAs signature (LMNTD2-AS1, AL589765.4, AC079298.3, U62317.3, LINC02446, AL645608.7, HSD11B1-AS1, AC009119.1, AC087239.1) was constructed as the prognostic model of breast cancer. Significant differences were discovered in immune cell distribution, immune function, immune checkpointand m6A-related protein expression between High risk group and Low risk group. The regulatory network of LncRNA-miRNA-mRNA was constructed and found to participate in the crosstalk among apoptosis, pyroptosis and necroptosis of breast cancer. Conclusions: The 9 lncRNAs signature was valuable for predicting breast cancer prognosis, and the pyroptosis-related lncRNAs influenced tumor immune microenvironment of breast cancer through the LncRNA-miRNA-mRNA regulatory network." @default.
• W3202198997 created "2021-10-11" @default.
• W3202198997 creator A5001904065 @default.
• W3202198997 creator A5057482433 @default.
• W3202198997 creator A5060640583 @default.
• W3202198997 creator A5082858469 @default.
• W3202198997 date "2021-09-27" @default.
• W3202198997 modified "2023-09-25" @default.
• W3202198997 title "The Pyroptosis-Related 9 LncRNA Signature and LncRNA-miRNA-mRNA Regulatory Network in Breast Cancer: A Comprehensive Analysis Based On TCGA Database" @default.
• W3202198997 cites W1536607091 @default.
• W3202198997 cites W1971290779 @default.
• W3202198997 cites W1984547206 @default.
• W3202198997 cites W1991912355 @default.
• W3202198997 cites W2042000848 @default.
• W3202198997 cites W2047484856 @default.
• W3202198997 cites W2088179569 @default.
• W3202198997 cites W2106393574 @default.
• W3202198997 cites W2108868935 @default.
• W3202198997 cites W2130153302 @default.
• W3202198997 cites W2143772132 @default.
• W3202198997 cites W2151721435 @default.
• W3202198997 cites W2407520682 @default.
• W3202198997 cites W2461915818 @default.
• W3202198997 cites W2463914344 @default.
• W3202198997 cites W2496277056 @default.
• W3202198997 cites W2553460354 @default.
• W3202198997 cites W2577773415 @default.
• W3202198997 cites W2585846097 @default.
• W3202198997 cites W2627048017 @default.
• W3202198997 cites W2731655388 @default.
• W3202198997 cites W2760104081 @default.
• W3202198997 cites W2783806340 @default.
• W3202198997 cites W2788140496 @default.
• W3202198997 cites W2790455265 @default.
• W3202198997 cites W2790885941 @default.
• W3202198997 cites W2805414697 @default.
• W3202198997 cites W2806723331 @default.
• W3202198997 cites W2885788218 @default.
• W3202198997 cites W2895588157 @default.
• W3202198997 cites W2923527365 @default.
• W3202198997 cites W2966176306 @default.
• W3202198997 cites W2970444068 @default.
• W3202198997 cites W2973831044 @default.
• W3202198997 cites W3003771615 @default.
• W3202198997 cites W3006529772 @default.
• W3202198997 cites W3016811071 @default.
• W3202198997 cites W3094316038 @default.
• W3202198997 cites W3109788673 @default.
• W3202198997 cites W3112188451 @default.
• W3202198997 cites W3116724422 @default.
• W3202198997 cites W3126198322 @default.
• W3202198997 cites W3158105994 @default.
• W3202198997 cites W3163601730 @default.
• W3202198997 cites W3176225874 @default.
• W3202198997 doi "https://doi.org/10.21203/rs.3.rs-889312/v1" @default.
• W3202198997 hasPublicationYear "2021" @default.
• W3202198997 type Work @default.
• W3202198997 sameAs 3202198997 @default.
• W3202198997 citedByCount "0" @default.
• W3202198997 crossrefType "posted-content" @default.
• W3202198997 hasAuthorship W3202198997A5001904065 @default.
• W3202198997 hasAuthorship W3202198997A5057482433 @default.
• W3202198997 hasAuthorship W3202198997A5060640583 @default.
• W3202198997 hasAuthorship W3202198997A5082858469 @default.
• W3202198997 hasBestOaLocation W32021989971 @default.
• W3202198997 hasConcept C104317684 @default.
• W3202198997 hasConcept C121608353 @default.
• W3202198997 hasConcept C143998085 @default.
• W3202198997 hasConcept C145059251 @default.
• W3202198997 hasConcept C150194340 @default.
• W3202198997 hasConcept C152724338 @default.
• W3202198997 hasConcept C162317418 @default.
• W3202198997 hasConcept C17172800 @default.
• W3202198997 hasConcept C190283241 @default.
• W3202198997 hasConcept C203014093 @default.
• W3202198997 hasConcept C31573885 @default.
• W3202198997 hasConcept C34626388 @default.
• W3202198997 hasConcept C530470458 @default.
• W3202198997 hasConcept C54355233 @default.
• W3202198997 hasConcept C70721500 @default.
• W3202198997 hasConcept C71924100 @default.
• W3202198997 hasConcept C86803240 @default.
• W3202198997 hasConcept C8891405 @default.
• W3202198997 hasConceptScore W3202198997C104317684 @default.
• W3202198997 hasConceptScore W3202198997C121608353 @default.
• W3202198997 hasConceptScore W3202198997C143998085 @default.
• W3202198997 hasConceptScore W3202198997C145059251 @default.
• W3202198997 hasConceptScore W3202198997C150194340 @default.
• W3202198997 hasConceptScore W3202198997C152724338 @default.
• W3202198997 hasConceptScore W3202198997C162317418 @default.
• W3202198997 hasConceptScore W3202198997C17172800 @default.
• W3202198997 hasConceptScore W3202198997C190283241 @default.
• W3202198997 hasConceptScore W3202198997C203014093 @default.
• W3202198997 hasConceptScore W3202198997C31573885 @default.
• W3202198997 hasConceptScore W3202198997C34626388 @default.
• W3202198997 hasConceptScore W3202198997C530470458 @default.
• W3202198997 hasConceptScore W3202198997C54355233 @default.
• W3202198997 hasConceptScore W3202198997C70721500 @default.
• W3202198997 hasConceptScore W3202198997C71924100 @default.
• W3202198997 hasConceptScore W3202198997C86803240 @default.

• next