Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202203791> ?p ?o ?g. }
- W3202203791 endingPage "655" @default.
- W3202203791 startingPage "634" @default.
- W3202203791 abstract "Directing the fates of human pluripotent stem cells (hPSC) to generate a multitude of differentiated cell types allows the study of the genetic regulation of human development and disease. The translational potential of hPSC is maximized by exploiting CRISPR to silence or activate genes with spatial and temporal precision permanently or reversibly. Here, we summarize the increasingly refined and diverse CRISPR toolkit for the latter forms of gene perturbation in hPSC and their downstream applications. We discuss newer methods to install edits efficiently with single nucleotide resolution and describe pooled CRISPR screens as a powerful means of unbiased discovery of genes associated with a phenotype of interest. Last, we discuss the potential of these combined technologies in the treatment of hitherto intractable human diseases and the challenges to their implementation in the clinic." @default.
- W3202203791 created "2021-10-11" @default.
- W3202203791 creator A5056161315 @default.
- W3202203791 creator A5060132061 @default.
- W3202203791 creator A5089641684 @default.
- W3202203791 date "2021-10-01" @default.
- W3202203791 modified "2023-10-16" @default.
- W3202203791 title "CRISPR-Cas Gene Perturbation and Editing in Human Induced Pluripotent Stem Cells" @default.
- W3202203791 cites W1519367368 @default.
- W3202203791 cites W1625273758 @default.
- W3202203791 cites W1751510803 @default.
- W3202203791 cites W1833135536 @default.
- W3202203791 cites W1976404496 @default.
- W3202203791 cites W1979229887 @default.
- W3202203791 cites W1984433385 @default.
- W3202203791 cites W1987609001 @default.
- W3202203791 cites W1991534639 @default.
- W3202203791 cites W1996788258 @default.
- W3202203791 cites W1997281938 @default.
- W3202203791 cites W1999098193 @default.
- W3202203791 cites W2003797386 @default.
- W3202203791 cites W2007594606 @default.
- W3202203791 cites W2008147758 @default.
- W3202203791 cites W2010711320 @default.
- W3202203791 cites W2014416902 @default.
- W3202203791 cites W2015327609 @default.
- W3202203791 cites W2016036293 @default.
- W3202203791 cites W2016297513 @default.
- W3202203791 cites W2018862827 @default.
- W3202203791 cites W2019670881 @default.
- W3202203791 cites W2026520402 @default.
- W3202203791 cites W2030974598 @default.
- W3202203791 cites W2032141669 @default.
- W3202203791 cites W2033609627 @default.
- W3202203791 cites W2034469326 @default.
- W3202203791 cites W2037338370 @default.
- W3202203791 cites W2041527069 @default.
- W3202203791 cites W2041797639 @default.
- W3202203791 cites W2045435533 @default.
- W3202203791 cites W2049358079 @default.
- W3202203791 cites W2051255304 @default.
- W3202203791 cites W2052553047 @default.
- W3202203791 cites W2059897301 @default.
- W3202203791 cites W2062710971 @default.
- W3202203791 cites W2064815984 @default.
- W3202203791 cites W2068427957 @default.
- W3202203791 cites W2079903460 @default.
- W3202203791 cites W2087875447 @default.
- W3202203791 cites W2089798460 @default.
- W3202203791 cites W2090630729 @default.
- W3202203791 cites W2094979867 @default.
- W3202203791 cites W2095950258 @default.
- W3202203791 cites W2101749257 @default.
- W3202203791 cites W2106070783 @default.
- W3202203791 cites W2107086950 @default.
- W3202203791 cites W2107959600 @default.
- W3202203791 cites W2108038398 @default.
- W3202203791 cites W2110260408 @default.
- W3202203791 cites W2114190644 @default.
- W3202203791 cites W2114232807 @default.
- W3202203791 cites W2116534141 @default.
- W3202203791 cites W2118918764 @default.
- W3202203791 cites W2120503144 @default.
- W3202203791 cites W2124833370 @default.
- W3202203791 cites W2127862779 @default.
- W3202203791 cites W2129171086 @default.
- W3202203791 cites W2134288637 @default.
- W3202203791 cites W2137065828 @default.
- W3202203791 cites W2138088258 @default.
- W3202203791 cites W2138977668 @default.
- W3202203791 cites W2141509764 @default.
- W3202203791 cites W2143301911 @default.
- W3202203791 cites W2146729586 @default.
- W3202203791 cites W2149402050 @default.
- W3202203791 cites W2152505144 @default.
- W3202203791 cites W2158023793 @default.
- W3202203791 cites W2163173465 @default.
- W3202203791 cites W2163248265 @default.
- W3202203791 cites W2165869860 @default.
- W3202203791 cites W2167380395 @default.
- W3202203791 cites W2168357216 @default.
- W3202203791 cites W2169244146 @default.
- W3202203791 cites W2169373177 @default.
- W3202203791 cites W2174099243 @default.
- W3202203791 cites W2188223075 @default.
- W3202203791 cites W2191690548 @default.
- W3202203791 cites W2202101415 @default.
- W3202203791 cites W2204861433 @default.
- W3202203791 cites W2206983740 @default.
- W3202203791 cites W2207047877 @default.
- W3202203791 cites W2207370113 @default.
- W3202203791 cites W2209402024 @default.
- W3202203791 cites W2224398381 @default.
- W3202203791 cites W2252568502 @default.
- W3202203791 cites W2273372803 @default.
- W3202203791 cites W2282791848 @default.
- W3202203791 cites W2285096912 @default.
- W3202203791 cites W2295326929 @default.