FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202206511> ?p ?o ?g. }

• W3202206511 abstract "It is hypothesized that several comorbidities increase the severity of COVID-19 symptoms. Cardiovascular disease including hypertension was shown to play a critical role in the severity of COVID-19 infection by affecting the survival of patients with COVID-19. Hypertension and the renin-angiotensin-aldosterone system are involved in increasing vascular inflammation and endothelial dysfunction (ED), and both processes are instrumental in COVID-19. Angiotensin-converting enzyme 2 is an essential component of the renin-angiotensin-aldosterone system and the target receptor that mediates SARS-CoV-2 entry to the cell. This led to speculations that major renin-angiotensin-aldosterone system inhibitors, such as angiotensin receptor blockers and angiotensin-converting enzyme inhibitors might affect the course of the disease, since their administration enhances angiotensin-converting enzyme (ACE)2 expression. An increase in ACE2 activity could reduce angiotensin II concentration in the lungs and mitigate virus-driven lung injury. This could also be associated with a reduction in blood coagulation, which plays a critical role in the pathogenesis of SARS-CoV-2; of note, COVID-19 is now regarded as a disorder of blood clotting. Therefore, there is an urgent need to better understand the effect of targeting ACE2 as a potential treatment for SARS-CoV-2 driven injury, and in alleviating COVID-19 symptoms by reversing SARS-CoV-2-induced excessive coagulation and fatalities. Ongoing therapeutic strategies that include recombinant human ACE2 and anti-spike monoclonal antibodies are essential for future clinical practice in order to better understand the effect of targeting ED in COVID-19." @default.
• W3202206511 created "2021-10-11" @default.
• W3202206511 creator A5055700265 @default.
• W3202206511 date "2021-10-07" @default.
• W3202206511 modified "2023-09-27" @default.
• W3202206511 title "Endothelial dysfunction and COVID‑19 (Review)" @default.
• W3202206511 cites W17887271 @default.
• W3202206511 cites W1976555160 @default.
• W3202206511 cites W2016176438 @default.
• W3202206511 cites W2028521865 @default.
• W3202206511 cites W2029971767 @default.
• W3202206511 cites W2035747909 @default.
• W3202206511 cites W2037817605 @default.
• W3202206511 cites W2051926037 @default.
• W3202206511 cites W2060171803 @default.
• W3202206511 cites W2066073474 @default.
• W3202206511 cites W2069044154 @default.
• W3202206511 cites W2069725690 @default.
• W3202206511 cites W2071831134 @default.
• W3202206511 cites W2092322150 @default.
• W3202206511 cites W2109657653 @default.
• W3202206511 cites W2140106465 @default.
• W3202206511 cites W2141099674 @default.
• W3202206511 cites W2146190354 @default.
• W3202206511 cites W2149395218 @default.
• W3202206511 cites W2157615046 @default.
• W3202206511 cites W2166469889 @default.
• W3202206511 cites W2255789882 @default.
• W3202206511 cites W2345539971 @default.
• W3202206511 cites W2528513111 @default.
• W3202206511 cites W2910432553 @default.
• W3202206511 cites W2912475067 @default.
• W3202206511 cites W3004348779 @default.
• W3202206511 cites W3005655936 @default.
• W3202206511 cites W3009799538 @default.
• W3202206511 cites W3009912996 @default.
• W3202206511 cites W3011610993 @default.
• W3202206511 cites W3011862945 @default.
• W3202206511 cites W3011995143 @default.
• W3202206511 cites W3012232836 @default.
• W3202206511 cites W3013302817 @default.
• W3202206511 cites W3014573995 @default.
• W3202206511 cites W3015146370 @default.
• W3202206511 cites W3017125154 @default.
• W3202206511 cites W3020735691 @default.
• W3202206511 cites W3022960164 @default.
• W3202206511 cites W3023751598 @default.
• W3202206511 cites W3028776453 @default.
• W3202206511 cites W3030177929 @default.
• W3202206511 cites W3033207790 @default.
• W3202206511 cites W3033509728 @default.
• W3202206511 cites W3034872024 @default.
• W3202206511 cites W3035819488 @default.
• W3202206511 cites W3036720715 @default.
• W3202206511 cites W3038411417 @default.
• W3202206511 cites W3042917242 @default.
• W3202206511 cites W3046806318 @default.
• W3202206511 cites W3047942098 @default.
• W3202206511 cites W3082011975 @default.
• W3202206511 cites W3082240102 @default.
• W3202206511 cites W3092997163 @default.
• W3202206511 cites W3116488354 @default.
• W3202206511 cites W3117854652 @default.
• W3202206511 cites W3122900688 @default.
• W3202206511 cites W3126852158 @default.
• W3202206511 cites W3156524022 @default.
• W3202206511 cites W3160491056 @default.
• W3202206511 cites W3194838995 @default.
• W3202206511 cites W4210642183 @default.
• W3202206511 doi "https://doi.org/10.3892/br.2021.1478" @default.
• W3202206511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8517756" @default.
• W3202206511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34667599" @default.
• W3202206511 hasPublicationYear "2021" @default.
• W3202206511 type Work @default.
• W3202206511 sameAs 3202206511 @default.
• W3202206511 citedByCount "5" @default.
• W3202206511 countsByYear W32022065112022 @default.
• W3202206511 countsByYear W32022065112023 @default.
• W3202206511 crossrefType "journal-article" @default.
• W3202206511 hasAuthorship W3202206511A5055700265 @default.
• W3202206511 hasBestOaLocation W32022065111 @default.
• W3202206511 hasConcept C126322002 @default.
• W3202206511 hasConcept C170493617 @default.
• W3202206511 hasConcept C198710026 @default.
• W3202206511 hasConcept C203014093 @default.
• W3202206511 hasConcept C27016395 @default.
• W3202206511 hasConcept C2775946041 @default.
• W3202206511 hasConcept C2779134260 @default.
• W3202206511 hasConcept C2780942790 @default.
• W3202206511 hasConcept C2780972559 @default.
• W3202206511 hasConcept C2908929049 @default.
• W3202206511 hasConcept C3008058167 @default.
• W3202206511 hasConcept C524204448 @default.
• W3202206511 hasConcept C71924100 @default.
• W3202206511 hasConcept C84393581 @default.
• W3202206511 hasConcept C98274493 @default.
• W3202206511 hasConceptScore W3202206511C126322002 @default.
• W3202206511 hasConceptScore W3202206511C170493617 @default.
• W3202206511 hasConceptScore W3202206511C198710026 @default.
• W3202206511 hasConceptScore W3202206511C203014093 @default.

• next