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- W3202214798 abstract "Abstract Preexisting immunity against seasonal coronaviruses (CoV) represents an important variable in predicting antibody responses and disease severity to Severe Acute Respiratory Syndrome CoV-2 (SARS-2) infections. We used electron microscopy based polyclonal epitope mapping (EMPEM) to characterize the antibody specificities against β-CoV spike proteins in sera from healthy donors (HDs) or SARS-2 convalescent donors (CDs). We observed that most HDs possessed antibodies specific to seasonal human CoVs (HCoVs) OC43 and HKU1 spike proteins while the CDs showed reactivity across all human β-CoVs. Detailed molecular mapping of spike-antibody complexes revealed epitopes that were differentially targeted by antibodies in preexisting and convalescent serum. Our studies provide an antigenic landscape to β-HCoV spikes in the general population serving as a basis for cross-reactive epitope analyses in SARS-2 -infected individuals. One-Sentence summary We present the epitope mapping of polyclonal antibodies against beta-coronavirus spike proteins in human sera." @default.
- W3202214798 created "2021-10-11" @default.
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- W3202214798 date "2021-10-01" @default.
- W3202214798 modified "2023-09-27" @default.
- W3202214798 title "Structural mapping of antibody landscapes to human betacoronavirus spike proteins" @default.
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- W3202214798 doi "https://doi.org/10.1101/2021.09.30.462459" @default.
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