FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202216474> ?p ?o ?g. }

• W3202216474 endingPage "103307" @default.
• W3202216474 startingPage "103307" @default.
• W3202216474 abstract "Aristolochic acid is a potent carcinogenic and nephrotoxic chemical found in all Aristolochia plants and the toxicity issue of aristolochic acid has gained increasing attention in recent years. To better understand the toxicity of aristolochic acid, we here explored to use Fourier transform infrared (FTIR) spectroscopy combined with chemometric analysis to investigate the biochemical changes of the liver and kidney tissues as well as plasma of a rat model due to aristolochic acid poisoning. We first collected the FTIR spectra of the plasma and tissue samples from the treatment group and the control group of the model rats. We then performed the chemometric analysis of these FTIR spectra using principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA). The interesting discovery was that when there was no distinctive change in the plasma samples due to aristolochic acid poisoning, there were already spectral changes in the liver and kidney samples which could be effectively distinguished by PCA and PLS-DA. Moreover, our chemometric analysis indicated that the aristolochic acid-induced damages on the liver tissue of model rats featured with lipid metabolism changes, while the biochemical changes caused by aristolochic acid on the kidney tissue seemed to be more complex. To the best of our knowledge, this work is the first application of FTIR spectroscopy combined with chemometric analysis in the investigation of the toxicity of aristolochic acid." @default.
• W3202216474 created "2021-10-11" @default.
• W3202216474 creator A5007043713 @default.
• W3202216474 creator A5048587663 @default.
• W3202216474 creator A5052180849 @default.
• W3202216474 creator A5052499322 @default.
• W3202216474 creator A5085649857 @default.
• W3202216474 date "2021-11-01" @default.
• W3202216474 modified "2023-10-16" @default.
• W3202216474 title "Toxicity of aristolochic acid in a rat model investigated by Fourier transform infrared spectroscopy combined with chemometric analysis: An exploratory study" @default.
• W3202216474 cites W1027826391 @default.
• W3202216474 cites W1580995169 @default.
• W3202216474 cites W1593695113 @default.
• W3202216474 cites W1935238887 @default.
• W3202216474 cites W1944363068 @default.
• W3202216474 cites W1955981296 @default.
• W3202216474 cites W1961147514 @default.
• W3202216474 cites W1966211080 @default.
• W3202216474 cites W1974000725 @default.
• W3202216474 cites W1975201824 @default.
• W3202216474 cites W1978741829 @default.
• W3202216474 cites W1985497226 @default.
• W3202216474 cites W1992975361 @default.
• W3202216474 cites W2011055829 @default.
• W3202216474 cites W2012163764 @default.
• W3202216474 cites W2012183591 @default.
• W3202216474 cites W2039514729 @default.
• W3202216474 cites W2040196730 @default.
• W3202216474 cites W2064359917 @default.
• W3202216474 cites W2065416237 @default.
• W3202216474 cites W2068666819 @default.
• W3202216474 cites W2070928663 @default.
• W3202216474 cites W2082312233 @default.
• W3202216474 cites W2096821223 @default.
• W3202216474 cites W2113155690 @default.
• W3202216474 cites W2117785761 @default.
• W3202216474 cites W2118241176 @default.
• W3202216474 cites W2139016195 @default.
• W3202216474 cites W2148091537 @default.
• W3202216474 cites W2160564267 @default.
• W3202216474 cites W2163109486 @default.
• W3202216474 cites W2173533727 @default.
• W3202216474 cites W2211132827 @default.
• W3202216474 cites W2277875555 @default.
• W3202216474 cites W2284129007 @default.
• W3202216474 cites W2303403809 @default.
• W3202216474 cites W2337722800 @default.
• W3202216474 cites W2417642615 @default.
• W3202216474 cites W2531428695 @default.
• W3202216474 cites W2605965537 @default.
• W3202216474 cites W2610649914 @default.
• W3202216474 cites W2635626043 @default.
• W3202216474 cites W2731599707 @default.
• W3202216474 cites W2751490203 @default.
• W3202216474 cites W2761692625 @default.
• W3202216474 cites W2764282355 @default.
• W3202216474 cites W2765243483 @default.
• W3202216474 cites W2779215143 @default.
• W3202216474 cites W2783513014 @default.
• W3202216474 cites W2803335983 @default.
• W3202216474 cites W2887244799 @default.
• W3202216474 cites W2887622681 @default.
• W3202216474 cites W2896470994 @default.
• W3202216474 cites W2967433009 @default.
• W3202216474 cites W2972308609 @default.
• W3202216474 cites W3007614069 @default.
• W3202216474 cites W949548515 @default.
• W3202216474 doi "https://doi.org/10.1016/j.vibspec.2021.103307" @default.
• W3202216474 hasPublicationYear "2021" @default.
• W3202216474 type Work @default.
• W3202216474 sameAs 3202216474 @default.
• W3202216474 citedByCount "2" @default.
• W3202216474 countsByYear W32022164742022 @default.
• W3202216474 countsByYear W32022164742023 @default.
• W3202216474 crossrefType "journal-article" @default.
• W3202216474 hasAuthorship W3202216474A5007043713 @default.
• W3202216474 hasAuthorship W3202216474A5048587663 @default.
• W3202216474 hasAuthorship W3202216474A5052180849 @default.
• W3202216474 hasAuthorship W3202216474A5052499322 @default.
• W3202216474 hasAuthorship W3202216474A5085649857 @default.
• W3202216474 hasConcept C121332964 @default.
• W3202216474 hasConcept C153642686 @default.
• W3202216474 hasConcept C160892712 @default.
• W3202216474 hasConcept C178790620 @default.
• W3202216474 hasConcept C185592680 @default.
• W3202216474 hasConcept C2780813843 @default.
• W3202216474 hasConcept C29730261 @default.
• W3202216474 hasConcept C43617362 @default.
• W3202216474 hasConcept C54355233 @default.
• W3202216474 hasConcept C62520636 @default.
• W3202216474 hasConcept C86803240 @default.
• W3202216474 hasConceptScore W3202216474C121332964 @default.
• W3202216474 hasConceptScore W3202216474C153642686 @default.
• W3202216474 hasConceptScore W3202216474C160892712 @default.
• W3202216474 hasConceptScore W3202216474C178790620 @default.
• W3202216474 hasConceptScore W3202216474C185592680 @default.
• W3202216474 hasConceptScore W3202216474C2780813843 @default.
• W3202216474 hasConceptScore W3202216474C29730261 @default.

• next