FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202227096> ?p ?o ?g. }

• W3202227096 endingPage "26612" @default.
• W3202227096 startingPage "26601" @default.
• W3202227096 abstract "Protein-protein interactions (PPIs) are fundamentally important and challenging drug targets. Peptidomimetic molecules of various types have been developed to modulate PPIs. A particularly promising drug discovery strategy, structural peptidomimetics, was designed based on special mimicking of side-chain Cα-Cβ bonds. It is simple and versatile. Nevertheless, no quantitative method has been established to evaluate its similarity to a target peptide motif. We developed two methods that enable visual, comprehensive, and quantitative analysis of peptidomimetics: peptide conformation distribution (PCD) plot and peptidomimetic analysis (PMA) map. These methods specifically examine multiple side-chain Cα-Cβ bonds of a peptide fragment motif and their corresponding bonds (pseudo-Cα-Cβ bonds) in a mimetic molecule instead of φ and ψ angles of a single amino acid in the traditional Ramachandran plot. The PCD plot is an alignment-free method, whereas the PMA map is an alignment-based method providing distinctive and complementary analysis. Results obtained from analysis using these two methods indicate our multifacial α-helix mimetic scaffold 12 as an excellent peptidomimetic that can precisely mimic the spatial positioning of side-chain functional groups of α-helix. These methods are useful for visualized and quantified evaluation of peptidomimetics and for the rational design of new mimetic scaffolds." @default.
• W3202227096 created "2021-10-11" @default.
• W3202227096 creator A5007768420 @default.
• W3202227096 creator A5036418983 @default.
• W3202227096 creator A5040030752 @default.
• W3202227096 creator A5043540242 @default.
• W3202227096 creator A5045282241 @default.
• W3202227096 creator A5047028371 @default.
• W3202227096 creator A5053819665 @default.
• W3202227096 creator A5087599039 @default.
• W3202227096 date "2021-09-27" @default.
• W3202227096 modified "2023-09-26" @default.
• W3202227096 title "Visualized and Quantitative Conformational Analysis of Peptidomimetics" @default.
• W3202227096 cites W1546896179 @default.
• W3202227096 cites W1576533924 @default.
• W3202227096 cites W1981174857 @default.
• W3202227096 cites W2005293003 @default.
• W3202227096 cites W2008708467 @default.
• W3202227096 cites W2011424390 @default.
• W3202227096 cites W2018221677 @default.
• W3202227096 cites W2021879240 @default.
• W3202227096 cites W2023004460 @default.
• W3202227096 cites W2036475318 @default.
• W3202227096 cites W2047962024 @default.
• W3202227096 cites W2049331965 @default.
• W3202227096 cites W2067837994 @default.
• W3202227096 cites W2070631343 @default.
• W3202227096 cites W2075770210 @default.
• W3202227096 cites W2091811407 @default.
• W3202227096 cites W2095154703 @default.
• W3202227096 cites W2145501898 @default.
• W3202227096 cites W2147495370 @default.
• W3202227096 cites W2159675169 @default.
• W3202227096 cites W2164316626 @default.
• W3202227096 cites W2165843192 @default.
• W3202227096 cites W2166631256 @default.
• W3202227096 cites W2166663852 @default.
• W3202227096 cites W230603162 @default.
• W3202227096 cites W2330001178 @default.
• W3202227096 cites W2330002776 @default.
• W3202227096 cites W2331465793 @default.
• W3202227096 cites W2476165513 @default.
• W3202227096 cites W2564506689 @default.
• W3202227096 cites W2618286039 @default.
• W3202227096 cites W2717151013 @default.
• W3202227096 cites W2751172723 @default.
• W3202227096 cites W2900344814 @default.
• W3202227096 cites W2963551192 @default.
• W3202227096 cites W3138154172 @default.
• W3202227096 cites W4255594044 @default.
• W3202227096 cites W597291126 @default.
• W3202227096 cites W78276363 @default.
• W3202227096 doi "https://doi.org/10.1021/acsomega.1c03967" @default.
• W3202227096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8515614" @default.
• W3202227096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34661014" @default.
• W3202227096 hasPublicationYear "2021" @default.
• W3202227096 type Work @default.
• W3202227096 sameAs 3202227096 @default.
• W3202227096 citedByCount "2" @default.
• W3202227096 countsByYear W32022270962022 @default.
• W3202227096 crossrefType "journal-article" @default.
• W3202227096 hasAuthorship W3202227096A5007768420 @default.
• W3202227096 hasAuthorship W3202227096A5036418983 @default.
• W3202227096 hasAuthorship W3202227096A5040030752 @default.
• W3202227096 hasAuthorship W3202227096A5043540242 @default.
• W3202227096 hasAuthorship W3202227096A5045282241 @default.
• W3202227096 hasAuthorship W3202227096A5047028371 @default.
• W3202227096 hasAuthorship W3202227096A5053819665 @default.
• W3202227096 hasAuthorship W3202227096A5087599039 @default.
• W3202227096 hasBestOaLocation W32022270961 @default.
• W3202227096 hasConcept C124790011 @default.
• W3202227096 hasConcept C14301744 @default.
• W3202227096 hasConcept C178790620 @default.
• W3202227096 hasConcept C185592680 @default.
• W3202227096 hasConcept C204921945 @default.
• W3202227096 hasConcept C21951064 @default.
• W3202227096 hasConcept C2779281246 @default.
• W3202227096 hasConcept C32909587 @default.
• W3202227096 hasConcept C47701112 @default.
• W3202227096 hasConcept C521977710 @default.
• W3202227096 hasConcept C55493867 @default.
• W3202227096 hasConcept C71240020 @default.
• W3202227096 hasConceptScore W3202227096C124790011 @default.
• W3202227096 hasConceptScore W3202227096C14301744 @default.
• W3202227096 hasConceptScore W3202227096C178790620 @default.
• W3202227096 hasConceptScore W3202227096C185592680 @default.
• W3202227096 hasConceptScore W3202227096C204921945 @default.
• W3202227096 hasConceptScore W3202227096C21951064 @default.
• W3202227096 hasConceptScore W3202227096C2779281246 @default.
• W3202227096 hasConceptScore W3202227096C32909587 @default.
• W3202227096 hasConceptScore W3202227096C47701112 @default.
• W3202227096 hasConceptScore W3202227096C521977710 @default.
• W3202227096 hasConceptScore W3202227096C55493867 @default.
• W3202227096 hasConceptScore W3202227096C71240020 @default.
• W3202227096 hasIssue "40" @default.
• W3202227096 hasLocation W32022270961 @default.
• W3202227096 hasLocation W32022270962 @default.
• W3202227096 hasLocation W32022270963 @default.

• next