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- W3202260834 abstract "EpigenomicsVol. 13, No. 18 CommentaryExosome-derived ncRNAs as potential drivers of epigenetic reprogramming of cancer stem cellsVijayashree Priyadharsini Jayaseelan & Paramasivam ArumugamVijayashree Priyadharsini Jayaseelan *Author for correspondence: E-mail Address: viji26priya@gmail.comhttps://orcid.org/0000-0001-7884-5466Clinical Genetics Lab, Cellular and Molecular Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 60077, Tamil Nadu, IndiaSearch for more papers by this author & Paramasivam Arumugam https://orcid.org/0000-0001-6117-1178Molecular Biology Lab, Cellular and Molecular Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 60077, Tamil Nadu, IndiaSearch for more papers by this authorPublished Online:1 Oct 2021https://doi.org/10.2217/epi-2021-0139AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: cancer stem cellschemoresistanceepigeneticsexosomeslncRNAmiRNArelapsestem cellstherapeutictumor microenvironmentReferences1. Sung H, Ferlay J, Siegel RL et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021).Crossref, Medline, Google Scholar2. Yang Y, Wang Y. Role of epigenetic regulation in plasticity of tumor immune microenvironment. Front. Immunol. 12, 640369 (2021).Crossref, Medline, CAS, Google Scholar3. Yang E, Wang X, Gong Z et al. Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduct. Target. Ther. 5(1), 242 (2020).Crossref, Medline, Google Scholar4. Tan S, Xia L, Yi P et al. Exosomal miRNAs in tumor microenvironment. J. Exp. Clin. Cancer Res. 39(1), 67 (2020).Crossref, Medline, Google Scholar5. Sansone P, Berishaj M, Rajasekhar VK et al. Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles. Cancer Res. 77(19), 5438 (2017).Crossref, Medline, Google Scholar6. Biswas S, Mandal G, Chowdhury SR et al. Exosomes produced by mesenchymal stem cells drive differentiation of myeloid cells into immunosuppressive M2-polarized macrophages in breast cancer. J. Immunol. 203(12), 3447–3460 (2019).Crossref, Medline, CAS, Google Scholar7. Xu J, Liao K, Zhou W. Exosomes regulate the transformation of cancer cells in cancer stem cell homeostasis. Stem Cells Int. 2018, 4837370 (2018).Crossref, Medline, Google Scholar8. Sun Z, Wang L, Dong L et al. Emerging role of exosome signalling in maintaining cancer stem cell dynamic equilibrium. J. Cell. Mol. Med. 22(8), 3719–3728 (2018).Crossref, Medline, Google Scholar9. Dai W, Jin X, Han L et al. Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma. Cell Death Dis. 11(9), 743 (2020).Crossref, Medline, CAS, Google Scholar10. Wang L, Bo X, Yi X et al. Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway. Cell Death Dis. 11(9), 723 (2020).Crossref, Medline, CAS, Google Scholar11. Wang L, He M, Fu L et al. Exosomal release of microRNA-454 by breast cancer cells sustains biological properties of cancer stem cells via the PRRT2/Wnt axis in ovarian cancer. Life Sci. 257, 118024 (2020).Crossref, Medline, CAS, Google Scholar12. Gao Z, Wang Q, Ji M et al. Exosomal lncRNA UCA1 modulates cervical cancer stem cell self-renewal and differentiation through microRNA-122-5p/SOX2 axis. J. Transl. Med. 19(1), 229 (2021).Crossref, Medline, CAS, Google Scholar13. Shen M, Dong C, Ruan X et al. Chemotherapy-induced extracellular vesicle miRNAs promote breast cancer stemness by targeting ONECUT2. Cancer Res. 79(14), 3608–3621 (2019).Crossref, Medline, CAS, Google Scholar14. Yang Q, Zhao S, Shi Z et al. Chemotherapy-elicited exosomal miR-378a-3p and miR-378d promote breast cancer stemness and chemoresistance via the activation of EZH2/STAT3 signaling. J. Exp. Clin. Cancer Res. 40(1), 120 (2021).Crossref, Medline, CAS, Google Scholar15. Lin H, Zhang L, Zhang C et al. Exosomal MiR-500a-3p promotes cisplatin resistance and stemness via negatively regulating FBXW7 in gastric cancer. J. Cell. Mol. Med. 24(16), 8930–8941 (2020).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByPost-transcriptional gene silencing by nucleic acid gapmers: a promising therapeutic modality for cancerJayaseelan Vijayashree Priyadharsini & Paramasivam Arumugam19 February 2023 | Epigenomics, Vol. 0, No. 0Exosome engineering: a promising step toward cancer therapeuticsVijayashree Priyadharsini Jayaseelan & Paramasivam Arumugam5 April 2022 | Epigenomics, Vol. 14, No. 9 Vol. 13, No. 18 Follow us on social media for the latest updates Metrics Downloaded 76 times History Received 24 April 2021 Accepted 10 September 2021 Published online 1 October 2021 Published in print September 2021 Information© 2021 Future Medicine LtdKeywordscancer stem cellschemoresistanceepigeneticsexosomeslncRNAmiRNArelapsestem cellstherapeutictumor microenvironmentAuthor contributionsConceptualization and draft writing: VP Jayaseelan. Draft writing and supervision: P Arumugam.Financial & competing interests disclosureThis work was supported by the Science and Engineering Research Board, Government of India, for the financial support rendered through core research grant (CRG/2019/003756). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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- W3202260834 title "Exosome-derived ncRNAs as potential drivers of epigenetic reprogramming of cancer stem cells" @default.
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