Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202278647> ?p ?o ?g. }
- W3202278647 abstract "Abstract Changes in epigenetic modifications present a mechanism how environmental factors like the experience of stress can alter gene regulation. While stress-related disorders have consistently been associated with differential DNA methylation, little is known about the time scale in which these alterations emerge. We investigated dynamic DNA methylation changes in whole blood of 42 healthy male individuals in response to a stressful cognitive task, its association with concentration changes in cortisol and its modulation by transcranial direct current stimulation (tDCS). We observed a continuous increase in COMT promotor DNA methylation which correlated with higher saliva cortisol levels and was still detectable one week later. However, this lasting effect was suppressed by concurrent activity-enhancing anodal tDCS to the dorsolateral prefrontal cortex. Our findings support the significance of gene-specific DNA methylation in whole blood as potential biomarkers for stress-related disorders. Moreover, they suggest alternative molecular mechanisms possibly involved in lasting behavioral effects of tDCS." @default.
- W3202278647 created "2021-10-11" @default.
- W3202278647 creator A5006814272 @default.
- W3202278647 creator A5035351399 @default.
- W3202278647 creator A5050095696 @default.
- W3202278647 creator A5054572977 @default.
- W3202278647 creator A5078354451 @default.
- W3202278647 creator A5085874970 @default.
- W3202278647 date "2021-10-02" @default.
- W3202278647 modified "2023-10-01" @default.
- W3202278647 title "Dynamic DNA methylation changes in the <i>COMT</i> gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation" @default.
- W3202278647 cites W1869592690 @default.
- W3202278647 cites W1964991065 @default.
- W3202278647 cites W1965672724 @default.
- W3202278647 cites W1979037268 @default.
- W3202278647 cites W1994130335 @default.
- W3202278647 cites W1995032020 @default.
- W3202278647 cites W2000399989 @default.
- W3202278647 cites W2006648514 @default.
- W3202278647 cites W2006949121 @default.
- W3202278647 cites W2008679805 @default.
- W3202278647 cites W2012531646 @default.
- W3202278647 cites W2022768282 @default.
- W3202278647 cites W2026159178 @default.
- W3202278647 cites W2029573440 @default.
- W3202278647 cites W2035403666 @default.
- W3202278647 cites W2035899017 @default.
- W3202278647 cites W2036194871 @default.
- W3202278647 cites W2040982509 @default.
- W3202278647 cites W2055686502 @default.
- W3202278647 cites W2061921583 @default.
- W3202278647 cites W2069717852 @default.
- W3202278647 cites W2074140050 @default.
- W3202278647 cites W2085626196 @default.
- W3202278647 cites W2094134651 @default.
- W3202278647 cites W2097075017 @default.
- W3202278647 cites W2100040984 @default.
- W3202278647 cites W2132152083 @default.
- W3202278647 cites W2133924917 @default.
- W3202278647 cites W2135835694 @default.
- W3202278647 cites W2136022845 @default.
- W3202278647 cites W2140289027 @default.
- W3202278647 cites W2146759661 @default.
- W3202278647 cites W2147422917 @default.
- W3202278647 cites W2152497434 @default.
- W3202278647 cites W2162178715 @default.
- W3202278647 cites W2162920783 @default.
- W3202278647 cites W2162932719 @default.
- W3202278647 cites W2165296496 @default.
- W3202278647 cites W2170760271 @default.
- W3202278647 cites W2285204915 @default.
- W3202278647 cites W2411013142 @default.
- W3202278647 cites W2412560454 @default.
- W3202278647 cites W2419644991 @default.
- W3202278647 cites W2426421998 @default.
- W3202278647 cites W2537707735 @default.
- W3202278647 cites W2562310878 @default.
- W3202278647 cites W2604382280 @default.
- W3202278647 cites W2762068325 @default.
- W3202278647 cites W2764096619 @default.
- W3202278647 cites W2794542396 @default.
- W3202278647 cites W2909205092 @default.
- W3202278647 cites W2918862101 @default.
- W3202278647 cites W2943515894 @default.
- W3202278647 cites W3005376563 @default.
- W3202278647 cites W3042752555 @default.
- W3202278647 cites W4234314512 @default.
- W3202278647 cites W4292994367 @default.
- W3202278647 doi "https://doi.org/10.1101/2021.10.01.462774" @default.
- W3202278647 hasPublicationYear "2021" @default.
- W3202278647 type Work @default.
- W3202278647 sameAs 3202278647 @default.
- W3202278647 citedByCount "3" @default.
- W3202278647 countsByYear W32022786472023 @default.
- W3202278647 crossrefType "posted-content" @default.
- W3202278647 hasAuthorship W3202278647A5006814272 @default.
- W3202278647 hasAuthorship W3202278647A5035351399 @default.
- W3202278647 hasAuthorship W3202278647A5050095696 @default.
- W3202278647 hasAuthorship W3202278647A5054572977 @default.
- W3202278647 hasAuthorship W3202278647A5078354451 @default.
- W3202278647 hasAuthorship W3202278647A5085874970 @default.
- W3202278647 hasBestOaLocation W32022786471 @default.
- W3202278647 hasConcept C104317684 @default.
- W3202278647 hasConcept C134018914 @default.
- W3202278647 hasConcept C150194340 @default.
- W3202278647 hasConcept C15744967 @default.
- W3202278647 hasConcept C169760540 @default.
- W3202278647 hasConcept C169900460 @default.
- W3202278647 hasConcept C190727270 @default.
- W3202278647 hasConcept C24998067 @default.
- W3202278647 hasConcept C2777803708 @default.
- W3202278647 hasConcept C2780508717 @default.
- W3202278647 hasConcept C2781195155 @default.
- W3202278647 hasConcept C33288867 @default.
- W3202278647 hasConcept C41091548 @default.
- W3202278647 hasConcept C54355233 @default.
- W3202278647 hasConcept C86803240 @default.
- W3202278647 hasConceptScore W3202278647C104317684 @default.
- W3202278647 hasConceptScore W3202278647C134018914 @default.
- W3202278647 hasConceptScore W3202278647C150194340 @default.