Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202287100> ?p ?o ?g. }
- W3202287100 endingPage "13679" @default.
- W3202287100 startingPage "13673" @default.
- W3202287100 abstract "Thrombin is an important biomarker for various diseases and biochemical reactions. Rapid and real-time detection of thrombin that quickly neutralizes in early coagulation in the body has gained significant attention for its practical applications. Solution-gated graphene transistors (SGGTs) have been widely studied due to their higher sensitivity and low-cost fabrication for chemical and biological sensing applications. In this paper, the ssDNA aptamer with 29 bases was immobilized on the surface of the gate electrode to specifically recognize thrombin. The SGGT sensor achieved high sensitivity with a limit of detection (LOD) up to fM. The LOD was attributed to the amplification function of SGGTs and the suitable aptamer choice. The ssDNA configuration folding induced by thrombin molecules and the electropositivity of thrombin molecules could arouse the same electrical response of SGGTs, helping the device obtain a high sensitivity. The channel current variation of sensors had a good linear relationship with the logarithm of thrombin concentration in the range of 1 fM to 10 nM. The fabricated device also demonstrated a short response time to thrombin molecules, and the response time to the 1 fM thrombin molecules was about 150 s. In summary, the sensing strategy of aptamer-based SGGTs with high sensitivity and high selectivity has a good prospect in medical diagnosis." @default.
- W3202287100 created "2021-10-11" @default.
- W3202287100 creator A5001097658 @default.
- W3202287100 creator A5011332111 @default.
- W3202287100 creator A5023737724 @default.
- W3202287100 creator A5042748706 @default.
- W3202287100 creator A5052484150 @default.
- W3202287100 creator A5056308805 @default.
- W3202287100 creator A5063795265 @default.
- W3202287100 creator A5069004207 @default.
- W3202287100 creator A5071798264 @default.
- W3202287100 creator A5083790493 @default.
- W3202287100 date "2021-10-01" @default.
- W3202287100 modified "2023-10-14" @default.
- W3202287100 title "Aptamer-Based Solution-Gated Graphene Transistors for Highly Sensitive and Real-Time Detection of Thrombin Molecules" @default.
- W3202287100 cites W1018953785 @default.
- W3202287100 cites W187459506 @default.
- W3202287100 cites W1963731836 @default.
- W3202287100 cites W1964890218 @default.
- W3202287100 cites W1977689290 @default.
- W3202287100 cites W1977769452 @default.
- W3202287100 cites W1980096532 @default.
- W3202287100 cites W1988034596 @default.
- W3202287100 cites W1993603706 @default.
- W3202287100 cites W2011195373 @default.
- W3202287100 cites W2016292888 @default.
- W3202287100 cites W2022117812 @default.
- W3202287100 cites W2032120414 @default.
- W3202287100 cites W2054586727 @default.
- W3202287100 cites W2058122340 @default.
- W3202287100 cites W2058604643 @default.
- W3202287100 cites W2081212045 @default.
- W3202287100 cites W2083403388 @default.
- W3202287100 cites W2091279081 @default.
- W3202287100 cites W2100851792 @default.
- W3202287100 cites W2121897924 @default.
- W3202287100 cites W2129308041 @default.
- W3202287100 cites W2144178455 @default.
- W3202287100 cites W2226530887 @default.
- W3202287100 cites W2330908373 @default.
- W3202287100 cites W2519441080 @default.
- W3202287100 cites W2560837649 @default.
- W3202287100 cites W2562183324 @default.
- W3202287100 cites W2603262868 @default.
- W3202287100 cites W2733149799 @default.
- W3202287100 cites W2754421102 @default.
- W3202287100 cites W2796923657 @default.
- W3202287100 cites W2800343591 @default.
- W3202287100 cites W2889270015 @default.
- W3202287100 cites W2923727276 @default.
- W3202287100 cites W2940741685 @default.
- W3202287100 cites W2945768260 @default.
- W3202287100 cites W2975249075 @default.
- W3202287100 cites W2997471978 @default.
- W3202287100 cites W2999321095 @default.
- W3202287100 cites W3000643884 @default.
- W3202287100 cites W3012231648 @default.
- W3202287100 cites W3012857947 @default.
- W3202287100 cites W3015636815 @default.
- W3202287100 cites W3016261387 @default.
- W3202287100 cites W3023244536 @default.
- W3202287100 cites W3047766902 @default.
- W3202287100 cites W3099484950 @default.
- W3202287100 cites W3103746303 @default.
- W3202287100 cites W3116024298 @default.
- W3202287100 cites W2072618981 @default.
- W3202287100 doi "https://doi.org/10.1021/acs.analchem.1c03129" @default.
- W3202287100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34597019" @default.
- W3202287100 hasPublicationYear "2021" @default.
- W3202287100 type Work @default.
- W3202287100 sameAs 3202287100 @default.
- W3202287100 citedByCount "17" @default.
- W3202287100 countsByYear W32022871002022 @default.
- W3202287100 countsByYear W32022871002023 @default.
- W3202287100 crossrefType "journal-article" @default.
- W3202287100 hasAuthorship W3202287100A5001097658 @default.
- W3202287100 hasAuthorship W3202287100A5011332111 @default.
- W3202287100 hasAuthorship W3202287100A5023737724 @default.
- W3202287100 hasAuthorship W3202287100A5042748706 @default.
- W3202287100 hasAuthorship W3202287100A5052484150 @default.
- W3202287100 hasAuthorship W3202287100A5056308805 @default.
- W3202287100 hasAuthorship W3202287100A5063795265 @default.
- W3202287100 hasAuthorship W3202287100A5069004207 @default.
- W3202287100 hasAuthorship W3202287100A5071798264 @default.
- W3202287100 hasAuthorship W3202287100A5083790493 @default.
- W3202287100 hasConcept C119128265 @default.
- W3202287100 hasConcept C119599485 @default.
- W3202287100 hasConcept C12554922 @default.
- W3202287100 hasConcept C127413603 @default.
- W3202287100 hasConcept C128972844 @default.
- W3202287100 hasConcept C153911025 @default.
- W3202287100 hasConcept C161624437 @default.
- W3202287100 hasConcept C165801399 @default.
- W3202287100 hasConcept C171250308 @default.
- W3202287100 hasConcept C172385210 @default.
- W3202287100 hasConcept C185592680 @default.
- W3202287100 hasConcept C192562407 @default.
- W3202287100 hasConcept C203014093 @default.