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- W3202302914 endingPage "1210" @default.
- W3202302914 startingPage "1210" @default.
- W3202302914 abstract "Background: Antimicrobial resistance is a major threat to humankind and the advancement of resistance due to genetic modifications and other defense mechanisms that make the current antibiotics ineffective or less efficacious. Objective: This investigation aims to isolate bioactive compounds from the leaf acetone extract of Terminalia catappa and to evaluate their antimicrobial potential against human pathogenic organisms. Materials and Methods: The bioactive extract was subjected to column chromatography. The fractions were assessed for their minimum inhibitory concentration, minimum fungicidal concentration, and time kill assays. UHPLC-MS/MS analysis was used to identify the bioactive molecules in the fraction. Results: The isolated fraction exhibited antimicrobial activity, with the most sensitive being Staphylococcus aureus (clinical isolate) and Methicillin Resistant Staphylococcus aureus 1503 (0.097 mg/mL), and the fungi Trichophyton rubrum and Candida albicans were inhibited at 0.097 mg/mL. The time kill assay exhibited bactericidal properties towards S. aureus (clinical isolate) and Salmonella typhi (MTCC 733). Additionally, MRSA 1503 and Proteus vulgaris exhibited bacteriostatic activities. The UHPLC-MS/MS analysis revealed that the fraction was rich in polyphenols. Alkaloids and some ellagitannins were identified for the first time. Conclusion: The results highlight the significant inhibition of multidrug-resistant MRSA strains and fungi by the polyphenol-rich fraction. The investigation reveals the potential use of the identified compounds for antimicrobial use, which could lower the implication of multidrug resistance." @default.
- W3202302914 created "2021-10-11" @default.
- W3202302914 creator A5007053820 @default.
- W3202302914 creator A5082988173 @default.
- W3202302914 date "2021-10-02" @default.
- W3202302914 modified "2023-10-16" @default.
- W3202302914 title "Polyphenol-Rich Purified Bioactive Fraction Isolated from Terminalia catappa L.: UHPLC-MS/MS-Based Metabolite Identification and Evaluation of Their Antimicrobial Potential" @default.
- W3202302914 cites W1092166013 @default.
- W3202302914 cites W1667661552 @default.
- W3202302914 cites W1833396308 @default.
- W3202302914 cites W1853764526 @default.
- W3202302914 cites W1876701072 @default.
- W3202302914 cites W1973964324 @default.
- W3202302914 cites W1982637196 @default.
- W3202302914 cites W1989364242 @default.
- W3202302914 cites W1998855247 @default.
- W3202302914 cites W2003190311 @default.
- W3202302914 cites W2013458793 @default.
- W3202302914 cites W2014551857 @default.
- W3202302914 cites W2021071651 @default.
- W3202302914 cites W2028879787 @default.
- W3202302914 cites W2029806260 @default.
- W3202302914 cites W2037641287 @default.
- W3202302914 cites W2041093395 @default.
- W3202302914 cites W2050986509 @default.
- W3202302914 cites W2051589663 @default.
- W3202302914 cites W2054265689 @default.
- W3202302914 cites W2054438768 @default.
- W3202302914 cites W2067670322 @default.
- W3202302914 cites W2069689127 @default.
- W3202302914 cites W2071585670 @default.
- W3202302914 cites W2072847229 @default.
- W3202302914 cites W2074615271 @default.
- W3202302914 cites W2085556012 @default.
- W3202302914 cites W2091930526 @default.
- W3202302914 cites W2097594005 @default.
- W3202302914 cites W2107221165 @default.
- W3202302914 cites W2109716174 @default.
- W3202302914 cites W2146531742 @default.
- W3202302914 cites W2147964197 @default.
- W3202302914 cites W2151633804 @default.
- W3202302914 cites W2327605074 @default.
- W3202302914 cites W2584402451 @default.
- W3202302914 cites W2588940121 @default.
- W3202302914 cites W2597231648 @default.
- W3202302914 cites W2597266501 @default.
- W3202302914 cites W2600333119 @default.
- W3202302914 cites W2604405926 @default.
- W3202302914 cites W2774030781 @default.
- W3202302914 cites W2795528817 @default.
- W3202302914 cites W2804655342 @default.
- W3202302914 cites W2805728975 @default.
- W3202302914 cites W2891573285 @default.
- W3202302914 cites W2892372509 @default.
- W3202302914 cites W2895839658 @default.
- W3202302914 cites W2902269439 @default.
- W3202302914 cites W2916856689 @default.
- W3202302914 cites W2922721845 @default.
- W3202302914 cites W2934656438 @default.
- W3202302914 cites W2946442314 @default.
- W3202302914 cites W2953093712 @default.
- W3202302914 cites W2957102650 @default.
- W3202302914 cites W2965208681 @default.
- W3202302914 cites W2969719167 @default.
- W3202302914 cites W2971746709 @default.
- W3202302914 cites W2972572954 @default.
- W3202302914 cites W2984597762 @default.
- W3202302914 cites W2987783202 @default.
- W3202302914 cites W2989212116 @default.
- W3202302914 cites W2993108081 @default.
- W3202302914 cites W2994740235 @default.
- W3202302914 cites W2998048149 @default.
- W3202302914 cites W2998049532 @default.
- W3202302914 cites W3000403835 @default.
- W3202302914 cites W3002189575 @default.
- W3202302914 cites W3002248513 @default.
- W3202302914 cites W3005331520 @default.
- W3202302914 cites W3006244418 @default.
- W3202302914 cites W3006696994 @default.
- W3202302914 cites W3008013079 @default.
- W3202302914 cites W3010687759 @default.
- W3202302914 cites W3013978484 @default.
- W3202302914 cites W3013984711 @default.
- W3202302914 cites W3029884904 @default.
- W3202302914 cites W3033107086 @default.
- W3202302914 cites W3046632500 @default.
- W3202302914 cites W3048280745 @default.
- W3202302914 cites W3049259703 @default.
- W3202302914 cites W3080849868 @default.
- W3202302914 cites W3082255586 @default.
- W3202302914 cites W3090370758 @default.
- W3202302914 cites W3092006589 @default.
- W3202302914 cites W3102474828 @default.
- W3202302914 cites W3106923768 @default.
- W3202302914 cites W3111545474 @default.
- W3202302914 cites W3125785079 @default.
- W3202302914 cites W3171151575 @default.
- W3202302914 cites W4232845044 @default.