FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202308342> ?p ?o ?g. }

• W3202308342 abstract "Background: Kidney transplantation (KTx) is a preeminent treatment for end-stage renal disease (ESRD). After the application of immunosuppressants (IS), renal allograft recipients could reach a state called accommodation which means they are neither rejected nor infected. This study aimed to describe the details of this immune accommodation and reveal a novel mechanism of IS on immune cell subpopulations. Methods: We analyzed multiple cell subgroups and their gene expression of peripheral T, B, myeloid, and NK cells from renal allograft recipients with accommodation and healthy control (HC) by single-cell transcriptomics sequencing (scRNA-seq) and flow cytometry. Results: A total of 8,272 cells were isolated and sequenced from three individuals, including 2,758 cells from HC, 2,550 cells from ESRD patient, and 2,964 cells from KTx patient, as well as 396 immune response-related genes were detected during sequencing. 5 T-cell, 4 NK-cell, 5 myeloid, and 4 B-cell clusters were defined. Among them, a B-cell subset (CD19+IGLC3lowIGKChighTCL1A-CD127+) of renal transplant recipients with accommodation was significantly lower than that of HC and verified by flow cytometry, and this B-cell subset showed an activated potential because of its high expression of CD127. Furthermore, we found that IL32 might be the key cytokine to induce the differentiation of this B-cell cluster. Conclusion: We found a novel B-cell subset (CD19+IGLC3lowIGKChighTCL1A-CD127+) which was inhibited and decreased in renal allograft recipients with accommodation. This study might reveal the effect of commonly used IS in clinical practice on B-cell subsets and related mechanism." @default.
• W3202308342 created "2021-10-11" @default.
• W3202308342 creator A5019560977 @default.
• W3202308342 creator A5029833484 @default.
• W3202308342 creator A5038442643 @default.
• W3202308342 creator A5042973046 @default.
• W3202308342 creator A5049531165 @default.
• W3202308342 creator A5063662414 @default.
• W3202308342 creator A5076709492 @default.
• W3202308342 creator A5077434225 @default.
• W3202308342 date "2021-09-30" @default.
• W3202308342 modified "2023-09-24" @default.
• W3202308342 title "Single-Cell Transcriptomic Analysis of Peripheral Blood Reveals a Novel B-Cell Subset in Renal Allograft Recipients With Accommodation" @default.
• W3202308342 cites W1972602689 @default.
• W3202308342 cites W2035618305 @default.
• W3202308342 cites W2069151737 @default.
• W3202308342 cites W2091236576 @default.
• W3202308342 cites W2331116430 @default.
• W3202308342 cites W2530893030 @default.
• W3202308342 cites W2765622700 @default.
• W3202308342 cites W2766291844 @default.
• W3202308342 cites W2808935368 @default.
• W3202308342 cites W2811169723 @default.
• W3202308342 cites W2883851634 @default.
• W3202308342 cites W2913337434 @default.
• W3202308342 cites W2914996830 @default.
• W3202308342 cites W2954434934 @default.
• W3202308342 cites W2961304458 @default.
• W3202308342 cites W2968872536 @default.
• W3202308342 cites W2980906098 @default.
• W3202308342 cites W3011416305 @default.
• W3202308342 cites W3032510268 @default.
• W3202308342 cites W3044539825 @default.
• W3202308342 cites W3096992432 @default.
• W3202308342 cites W3111428798 @default.
• W3202308342 cites W3127778900 @default.
• W3202308342 cites W3133178690 @default.
• W3202308342 doi "https://doi.org/10.3389/fphar.2021.706580" @default.
• W3202308342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8514638" @default.
• W3202308342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34658852" @default.
• W3202308342 hasPublicationYear "2021" @default.
• W3202308342 type Work @default.
• W3202308342 sameAs 3202308342 @default.
• W3202308342 citedByCount "4" @default.
• W3202308342 countsByYear W32023083422022 @default.
• W3202308342 countsByYear W32023083422023 @default.
• W3202308342 crossrefType "journal-article" @default.
• W3202308342 hasAuthorship W3202308342A5019560977 @default.
• W3202308342 hasAuthorship W3202308342A5029833484 @default.
• W3202308342 hasAuthorship W3202308342A5038442643 @default.
• W3202308342 hasAuthorship W3202308342A5042973046 @default.
• W3202308342 hasAuthorship W3202308342A5049531165 @default.
• W3202308342 hasAuthorship W3202308342A5063662414 @default.
• W3202308342 hasAuthorship W3202308342A5076709492 @default.
• W3202308342 hasAuthorship W3202308342A5077434225 @default.
• W3202308342 hasBestOaLocation W32023083421 @default.
• W3202308342 hasConcept C123982805 @default.
• W3202308342 hasConcept C126322002 @default.
• W3202308342 hasConcept C1491633281 @default.
• W3202308342 hasConcept C159654299 @default.
• W3202308342 hasConcept C203014093 @default.
• W3202308342 hasConcept C2776090121 @default.
• W3202308342 hasConcept C2778453870 @default.
• W3202308342 hasConcept C2778957590 @default.
• W3202308342 hasConcept C2779134260 @default.
• W3202308342 hasConcept C2779282312 @default.
• W3202308342 hasConcept C2780303639 @default.
• W3202308342 hasConcept C2911091166 @default.
• W3202308342 hasConcept C3019040382 @default.
• W3202308342 hasConcept C54355233 @default.
• W3202308342 hasConcept C553184892 @default.
• W3202308342 hasConcept C71924100 @default.
• W3202308342 hasConcept C79484868 @default.
• W3202308342 hasConcept C86803240 @default.
• W3202308342 hasConcept C8891405 @default.
• W3202308342 hasConceptScore W3202308342C123982805 @default.
• W3202308342 hasConceptScore W3202308342C126322002 @default.
• W3202308342 hasConceptScore W3202308342C1491633281 @default.
• W3202308342 hasConceptScore W3202308342C159654299 @default.
• W3202308342 hasConceptScore W3202308342C203014093 @default.
• W3202308342 hasConceptScore W3202308342C2776090121 @default.
• W3202308342 hasConceptScore W3202308342C2778453870 @default.
• W3202308342 hasConceptScore W3202308342C2778957590 @default.
• W3202308342 hasConceptScore W3202308342C2779134260 @default.
• W3202308342 hasConceptScore W3202308342C2779282312 @default.
• W3202308342 hasConceptScore W3202308342C2780303639 @default.
• W3202308342 hasConceptScore W3202308342C2911091166 @default.
• W3202308342 hasConceptScore W3202308342C3019040382 @default.
• W3202308342 hasConceptScore W3202308342C54355233 @default.
• W3202308342 hasConceptScore W3202308342C553184892 @default.
• W3202308342 hasConceptScore W3202308342C71924100 @default.
• W3202308342 hasConceptScore W3202308342C79484868 @default.
• W3202308342 hasConceptScore W3202308342C86803240 @default.
• W3202308342 hasConceptScore W3202308342C8891405 @default.
• W3202308342 hasFunder F4320322843 @default.
• W3202308342 hasFunder F4320327720 @default.
• W3202308342 hasLocation W32023083421 @default.
• W3202308342 hasLocation W32023083422 @default.
• W3202308342 hasLocation W32023083423 @default.
• W3202308342 hasOpenAccess W3202308342 @default.

• next