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• W3202359711 abstract "Abstract For antibiotic resistance to arise, new resistant mutants must establish in a bacterial population before they can spread via natural selection. Comprehending the stochastic factors that influence mutant establishment is crucial for a quantitative understanding of antibiotic resistance emergence. Here, we quantify the single-cell establishment probability of four Escherichia coli strains expressing β-lactamase alleles with different activity against the antibiotic cefotaxime, as a function of antibiotic concentration in both unstructured (liquid) and structured (agar) environments. We show that concentrations well below the minimum inhibitory concentration (MIC) can substantially hamper establishment, particularly for highly resistant mutants. While the pattern of establishment suppression is comparable in both tested environments, we find greater variability in establishment probability on agar. Using a simple branching model, we investigate possible sources of this stochasticity, including environment-dependent lineage variability. Lastly, we use the single-cell establishment probability to predict each strain’s MIC in the absence of social interactions. We observe substantially higher measured than predicted MIC values, particularly for highly resistant strains, which indicates cooperative effects among resistant cells at large cell numbers, such as in standard MIC assays." @default.
• W3202359711 created "2021-10-11" @default.
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• W3202359711 date "2021-02-11" @default.
• W3202359711 modified "2023-10-18" @default.
• W3202359711 title "Stochastic effects during the establishment of β-lactam resistant <i>E. coli</i> mutants indicate conditions for collective resistance" @default.
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• W3202359711 doi "https://doi.org/10.1101/2021.02.09.430436" @default.
• W3202359711 hasPublicationYear "2021" @default.
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