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- W3202368408 abstract "Abstract Objective Ulcerative colitis (UC) is an independent risk factor for thromboembolism, especially during the perioperative period. This study aimed to determine the effects of perioperative parenteral nutrition (PN) supplemented with fish oil (FO) on coagulation function and postoperative outcomes in patients with UC. Methods This retrospective cohort included 92 consecutive patients who underwent colectomy for UC. Postoperative coagulation indices and outcomes, including thromboelastography (TEG) findings and comprehensive complication index (CCI), were compared. The relative change in serum D‐dimer (ΔD‐dimer) levels and maximal amplitude (ΔMA) on TEG were also determined. Results Patients receiving PN supplemented with FO ( n = 48) had lower D‐dimer ( P = .036) levels on postoperative day (POD) 5 and a higher MA ( P < 0.001) on POD 1 than those who did not receive it ( n = 44). A lower ΔD‐dimer level ( P = .048) and ΔMA ( P < 0.001) were also observed in patients receiving FO. The incidence of major postoperative complications (6.3 vs 22.7%; P = .017) and CCI (20.9 vs 23.4%; P = .044) were significantly lower in patients receiving FO. In multivariate analysis, FO (odds ratio, 0.231; 95% confidence interval, 0.055–0.971; P = .046) was a positive protector of major postoperative complications. Conclusion Perioperative PN supplemented with FO improved coagulation function and reduced major postoperative complications in patients with UC requiring colectomy. These results may provide cues in formulating management strategies for preventing thromboembolisms and postoperative complications in patients with UC." @default.
- W3202368408 created "2021-10-11" @default.
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- W3202368408 date "2021-10-21" @default.
- W3202368408 modified "2023-09-26" @default.
- W3202368408 title "Perioperative parenteral fish oil supplementation improves postoperative coagulation function and outcomes in patients undergoing colectomy for ulcerative colitis" @default.
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- W3202368408 doi "https://doi.org/10.1002/jpen.2269" @default.
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