FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202382815> ?p ?o ?g. }

• W3202382815 abstract "<h3>Background</h3> Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality in adults. Arterial structure and function changes that increase arterial stiffness occur gradually over years but may be influenced by the perinatal environment. <h3>Objectives</h3> To systematically review the literature to determine how the perinatal environment impacts arterial structure and function in preadolescent children, following PRISMA guidelines. <h3>Methods</h3> PubMed was searched using the terms: ‘pulse wave velocity’ (PWV), ‘carotid intima-media thickness’ (cIMT), ‘arterial stiffness index’ (SIx), ‘flow-mediated dilation’ (FMD), ‘flow imaging’, ‘laser flow Doppler’, ‘venous plethysmography’, ‘cardi* magnetic resonance imaging’, ‘aortic intima-media thickness’ (aIMT), ‘vascular ultrasound’ and ‘neonat*’, ‘paediatric’, ‘infant*’, ‘child*’. Case reports, case series, reviews, commentaries, conference proceedings, animal studies, articles not in English and articles with children >12 years old were excluded. Articles exploring the impact of perinatal factors on arterial structure and function were included. <h3>Results</h3> 28/1084 studies identified were included. PWV, a measure of arterial stiffness, was performed in 20 studies, including brachio-femoral (bfPWV), carotid-femoral (cfPWV), brachio-radial (brPWV) and aortic PWV (aPWV). Two studies measured the augmentation index (AIx), and two measured stiffness index (SIx), both indicators of vessel stiffness. Five studies measured cIMT and aIMT, since wall thickness can influence arterial stiffness. 17/28 studies explored perinatal maternal factors. Maternal age, serum ferritin, ethnicity, and psychosocial stress did not significantly impact neonatal PWV. Oily fish consumption in late pregnancy was associated with lower childhood aortic PWV (0.084m/s/portion/week; 95% CI: −0.137 to −0.031;<i> p</i>=0.002); maternal alcohol consumption in the second trimester was associated with increased cfPWV at 9 years (0.2m/s higher; 95% CI: 0.06 – 0.4, <i>p</i>=0.02). Maternal diabetes was associated with higher neonatal and infant PWV (two studies). The reported impact of maternal blood pressure (BP) varied: no association was found with infant bfPWV, but an inverse relationship was found between neonatal aPWV and maternal BP (r=-0.57m/s; 95% CI -0.67 to -0.45). cIMT in five-year-olds was 0.61μm greater per 1mmHg increased maternal BP. Eight studies explored the impact of fetal growth restriction (FGR) or small for gestational age (SGA), and three explored prematurity. FGR infants had a greater rise in brPWV between 1 week and 6 months old compared to appropriately grown infants (1.5 vs 0.9cm/s increase, <i>p</i>=0.03); however, aPWV and SIx did not differ between groups. One-week-old SGA infants had higher weight-adjusted aIMT (383±163 vs 256±43μm/kg, <i>p</i>≤0.001) and SIx (2.0±1.7 vs 1.1±0.4β/kg, <i>p</i>=0.005) than appropriately grown infants. Prematurity was associated with increased aortic stiffness in 2/3 studies: for example, AIx values were 5% higher (95% CI: 2%-8%) in 11-year-olds born ≤25 weeks. However, in six-year-olds, SIx and cIMT were similar in term and preterm (<27 weeks) cohorts. <h3>Conclusions</h3> Studies included used diverse methods and different ages of participants, and inconsistent definitions for SGA/FGR were applied. Nevertheless, the perinatal environment appears to influence offspring arterial structure and function in preadolescent children. Future research should aim to establish reference values for arterial stiffness-related measures in preadolescent children using consistent methodologies, in order to allow earlier, targeted clinical and public health interventions focused on those at the highest long-term cardiovascular risk." @default.
• W3202382815 created "2021-10-11" @default.
• W3202382815 creator A5016672267 @default.
• W3202382815 creator A5021881298 @default.
• W3202382815 creator A5051013251 @default.
• W3202382815 creator A5056533239 @default.
• W3202382815 creator A5059150079 @default.
• W3202382815 creator A5077209608 @default.
• W3202382815 creator A5090973154 @default.
• W3202382815 date "2021-09-30" @default.
• W3202382815 modified "2023-09-25" @default.
• W3202382815 title "781 Impact of perinatal factors on biomarkers of cardiovascular disease risk in preadolescent children" @default.
• W3202382815 doi "https://doi.org/10.1136/archdischild-2021-rcpch.195" @default.
• W3202382815 hasPublicationYear "2021" @default.
• W3202382815 type Work @default.
• W3202382815 sameAs 3202382815 @default.
• W3202382815 citedByCount "0" @default.
• W3202382815 crossrefType "proceedings-article" @default.
• W3202382815 hasAuthorship W3202382815A5016672267 @default.
• W3202382815 hasAuthorship W3202382815A5021881298 @default.
• W3202382815 hasAuthorship W3202382815A5051013251 @default.
• W3202382815 hasAuthorship W3202382815A5056533239 @default.
• W3202382815 hasAuthorship W3202382815A5059150079 @default.
• W3202382815 hasAuthorship W3202382815A5077209608 @default.
• W3202382815 hasAuthorship W3202382815A5090973154 @default.
• W3202382815 hasBestOaLocation W32023828151 @default.
• W3202382815 hasConcept C109982973 @default.
• W3202382815 hasConcept C126322002 @default.
• W3202382815 hasConcept C164705383 @default.
• W3202382815 hasConcept C2775850156 @default.
• W3202382815 hasConcept C2778319312 @default.
• W3202382815 hasConcept C2779339615 @default.
• W3202382815 hasConcept C2987047532 @default.
• W3202382815 hasConcept C57900726 @default.
• W3202382815 hasConcept C71924100 @default.
• W3202382815 hasConcept C84393581 @default.
• W3202382815 hasConceptScore W3202382815C109982973 @default.
• W3202382815 hasConceptScore W3202382815C126322002 @default.
• W3202382815 hasConceptScore W3202382815C164705383 @default.
• W3202382815 hasConceptScore W3202382815C2775850156 @default.
• W3202382815 hasConceptScore W3202382815C2778319312 @default.
• W3202382815 hasConceptScore W3202382815C2779339615 @default.
• W3202382815 hasConceptScore W3202382815C2987047532 @default.
• W3202382815 hasConceptScore W3202382815C57900726 @default.
• W3202382815 hasConceptScore W3202382815C71924100 @default.
• W3202382815 hasConceptScore W3202382815C84393581 @default.
• W3202382815 hasLocation W32023828151 @default.
• W3202382815 hasOpenAccess W3202382815 @default.
• W3202382815 hasPrimaryLocation W32023828151 @default.
• W3202382815 hasRelatedWork W1985768836 @default.
• W3202382815 hasRelatedWork W2015980916 @default.
• W3202382815 hasRelatedWork W2075843988 @default.
• W3202382815 hasRelatedWork W2077122544 @default.
• W3202382815 hasRelatedWork W3024619661 @default.
• W3202382815 hasRelatedWork W3092993382 @default.
• W3202382815 hasRelatedWork W3136847640 @default.
• W3202382815 hasRelatedWork W35780454 @default.
• W3202382815 hasRelatedWork W4285742024 @default.
• W3202382815 hasRelatedWork W4287377979 @default.
• W3202382815 isParatext "false" @default.
• W3202382815 isRetracted "false" @default.
• W3202382815 magId "3202382815" @default.
• W3202382815 workType "article" @default.