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• W3202401650 abstract "Mosquitoes serve as the major vector transmitting malaria, dengue, yellow fever and several other diseases of human concern. Rising in mosquito-borne diseases and consequent fatalities throughout the world has made the management of mosquitoes of paramount importance. With the use of various insecticidal agents and their indiscriminate application in the fields for vector control; other issues such as multiple insecticide resistance, lethality to non-specific targets and adverse effects on human and environmental health have emerged making the situation more critical. Hence, the focus of researchers has diverted to the use of Insect Growth Regulators (IGRs) that affect the growth and development of the insects without inducing any appreciable toxic effects. The paper comprehensively reviews various IGRs and their potential use against insect pests and mosquito vectors. A special emphasis has been laid on the utilization of diflubenzuron, its larvicidal potency and growth regulatory effects against mosquitoes. The paper also delivers a detailed discussion on various approaches governing with the application of diflubenzuron, a chitin synthesis inhibitor, for its potent effects over a wide range of other insect species, low toxicity to humans, safety to other non-target animals, negligible deleterious environmental impact along with the possible development of resistance in the mosquitoes, thereby providing insights and the direction for the future in terms of the innovative and technological perspective. Keeping in view the role of multifarious mechanisms in the development of resistance; use of various synergistic compounds, such as hydrolase inhibitors - profenofos and S,S,S-tributyl phosphorotrithioate; glutathione S-transferase inhibitor – diethylmaleate; and oxidase inhibitor - piperonyl butoxide (PBO); has been recommended in combination with IGRs to enhance their efficacy, and reduce or reverse the resistance in target mosquitoes. Another compound, verapamil, has been found extremely efficient in imparting synergistic effect to diflubenzuron by inhibiting P-glycoproteins, a transporter of the insecticides causing their efflux from the cell. Recommendations have been made for safe and effective mosquito control measures, adequate policies and increased awareness about the mosquito-borne diseases among the masses. In addition, regular surveillance of mosquitoes is endorsed for the formulation of an efficient mosquito management strategy." @default.
• W3202401650 created "2021-10-11" @default.
• W3202401650 creator A5063159988 @default.
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• W3202401650 date "2023-02-01" @default.
• W3202401650 modified "2023-09-24" @default.
• W3202401650 title "A systematic review on the eco-safe management of mosquitoes with diflubenzuron: An effective growth regulatory agent" @default.
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• W3202401650 doi "https://doi.org/10.1016/j.chnaes.2021.09.019" @default.
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