FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202435447> ?p ?o ?g. }

• W3202435447 abstract "Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by repetitive behaviors, poor social skills, and difficulties with communication and hearing. The hearing deficits in ASD range from deafness to extreme sensitivity to routine environmental sounds. Previous research from our lab has shown drastic hypoplasia in the superior olivary complex (SOC) in both human cases of ASD and in an animal model of autism. However, in our study of the human SOC, we failed to find any changes in the total number of neurons in the ventral nucleus of the trapezoid body (VNTB) or any changes in cell body size or shape. Similarly, in animals prenatally exposed to the antiepileptic valproic acid (VPA), we failed to find any changes in the total number, size or shape of VNTB neurons. Based on these findings, we hypothesized that the neurotransmitter profiles, ascending and descending axonal projections of the VNTB are also preserved in these neurodevelopmental conditions. We investigated this hypothesis using a combination of immunohistochemistry and retrograde tract tracing. We found no difference between control and VPA-exposed animals in the number of VNTB neurons immunoreactive for choline acetyltransferase (ChAT). Additionally, we investigated the ascending projections from the VNTB to both the central nucleus of the inferior colliculus (CNIC) and medial geniculate (MG) and descending projections to the cochlea. Our results indicate no significant differences in the ascending and descending projections from the VNTB between control and VPA-exposed animals despite drastic changes in these projections from surrounding nuclei. These findings provide evidence that certain neuronal populations and circuits may be protected against the effects of neurodevelopmental disorders." @default.
• W3202435447 created "2021-10-11" @default.
• W3202435447 creator A5064579300 @default.
• W3202435447 creator A5070250336 @default.
• W3202435447 date "2021-09-29" @default.
• W3202435447 modified "2023-09-24" @default.
• W3202435447 title "The Untouchable Ventral Nucleus of the Trapezoid Body: Preservation of a Nucleus in an Animal Model of Autism Spectrum Disorder" @default.
• W3202435447 cites W1820958579 @default.
• W3202435447 cites W1878529568 @default.
• W3202435447 cites W1908867824 @default.
• W3202435447 cites W1963833174 @default.
• W3202435447 cites W1980247150 @default.
• W3202435447 cites W1983538571 @default.
• W3202435447 cites W1987388499 @default.
• W3202435447 cites W1987493092 @default.
• W3202435447 cites W1991167146 @default.
• W3202435447 cites W1996455663 @default.
• W3202435447 cites W1996952785 @default.
• W3202435447 cites W1999912453 @default.
• W3202435447 cites W2001002126 @default.
• W3202435447 cites W2005656105 @default.
• W3202435447 cites W2017055292 @default.
• W3202435447 cites W2020437720 @default.
• W3202435447 cites W2021148835 @default.
• W3202435447 cites W2021180907 @default.
• W3202435447 cites W2022351541 @default.
• W3202435447 cites W2030344200 @default.
• W3202435447 cites W2034223677 @default.
• W3202435447 cites W2035412866 @default.
• W3202435447 cites W2036480281 @default.
• W3202435447 cites W2037398636 @default.
• W3202435447 cites W2037618838 @default.
• W3202435447 cites W2040219368 @default.
• W3202435447 cites W2040726954 @default.
• W3202435447 cites W2042592919 @default.
• W3202435447 cites W2042673772 @default.
• W3202435447 cites W2043365657 @default.
• W3202435447 cites W2051001254 @default.
• W3202435447 cites W2053403394 @default.
• W3202435447 cites W2055981668 @default.
• W3202435447 cites W2057229298 @default.
• W3202435447 cites W2070859428 @default.
• W3202435447 cites W2073299505 @default.
• W3202435447 cites W2077862797 @default.
• W3202435447 cites W2081904103 @default.
• W3202435447 cites W2084403228 @default.
• W3202435447 cites W2093333769 @default.
• W3202435447 cites W2093856225 @default.
• W3202435447 cites W2107555020 @default.
• W3202435447 cites W2111373002 @default.
• W3202435447 cites W2117487291 @default.
• W3202435447 cites W2128087515 @default.
• W3202435447 cites W2128778628 @default.
• W3202435447 cites W2137154110 @default.
• W3202435447 cites W2137265280 @default.
• W3202435447 cites W2140748565 @default.
• W3202435447 cites W2143309726 @default.
• W3202435447 cites W2157101683 @default.
• W3202435447 cites W2159568537 @default.
• W3202435447 cites W2165837966 @default.
• W3202435447 cites W2166216658 @default.
• W3202435447 cites W2167279371 @default.
• W3202435447 cites W2203502040 @default.
• W3202435447 cites W2274708352 @default.
• W3202435447 cites W2540237814 @default.
• W3202435447 cites W2792839927 @default.
• W3202435447 cites W2901288649 @default.
• W3202435447 cites W2949856622 @default.
• W3202435447 cites W2980319900 @default.
• W3202435447 cites W3001695910 @default.
• W3202435447 cites W3026266806 @default.
• W3202435447 cites W3101651672 @default.
• W3202435447 cites W4235387386 @default.
• W3202435447 cites W4243550072 @default.
• W3202435447 doi "https://doi.org/10.3389/fnint.2021.730439" @default.
• W3202435447 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8511769" @default.
• W3202435447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34658803" @default.
• W3202435447 hasPublicationYear "2021" @default.
• W3202435447 type Work @default.
• W3202435447 sameAs 3202435447 @default.
• W3202435447 citedByCount "4" @default.
• W3202435447 countsByYear W32024354472022 @default.
• W3202435447 countsByYear W32024354472023 @default.
• W3202435447 crossrefType "journal-article" @default.
• W3202435447 hasAuthorship W3202435447A5064579300 @default.
• W3202435447 hasAuthorship W3202435447A5070250336 @default.
• W3202435447 hasBestOaLocation W32024354471 @default.
• W3202435447 hasConcept C105702510 @default.
• W3202435447 hasConcept C118552586 @default.
• W3202435447 hasConcept C15744967 @default.
• W3202435447 hasConcept C169760540 @default.
• W3202435447 hasConcept C198399640 @default.
• W3202435447 hasConcept C205778803 @default.
• W3202435447 hasConcept C2775980177 @default.
• W3202435447 hasConcept C2777662796 @default.
• W3202435447 hasConcept C2778037994 @default.
• W3202435447 hasConcept C2778538070 @default.
• W3202435447 hasConcept C2779388368 @default.
• W3202435447 hasConcept C2780327212 @default.
• W3202435447 hasConcept C2780723820 @default.

• next