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- W3202485622 abstract "There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time, which severely restricts its applications for clinical and research purposes. Building on a recently developed technique of acquisition‐reconstruction for 2D MRSI, we combined a fast Cartesian 1 H‐FID‐MRSI acquisition sequence, compressed‐sensing acceleration, and low‐rank total‐generalized‐variation constrained reconstruction to produce 3D high‐resolution whole‐brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully sampled dataset. Second, a 20 min accelerated MRSI acquisition was performed on three healthy volunteers, resulting in metabolite maps with 5 mm isotropic resolution. The metabolite maps exhibited the detailed neurochemical composition of all brain regions and revealed parts of the underlying brain anatomy. The latter assessment used previous reported knowledge and a atlas‐based analysis to show consistency of the concentration contrasts and ratio across all brain regions. These results acquired on a clinical 3 T MRI scanner successfully combined 3D 1 H‐FID‐MRSI with a constrained reconstruction to produce detailed mapping of metabolite concentrations at high resolution over the whole brain, with an acquisition time suitable for clinical or research settings." @default.
- W3202485622 created "2021-10-11" @default.
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- W3202485622 date "2021-10-01" @default.
- W3202485622 modified "2023-10-14" @default.
- W3202485622 title "Whole‐brain high‐resolution metabolite mapping with 3D compressed‐sensing SENSE low‐rank <sup>1</sup>H FID‐MRSI" @default.
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- W3202485622 doi "https://doi.org/10.1002/nbm.4615" @default.
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