FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202514982> ?p ?o ?g. }

• W3202514982 endingPage "227" @default.
• W3202514982 startingPage "219" @default.
• W3202514982 abstract "Caveolin-1 (CAV1) in cancer-associated fibroblasts (CAFs) has pro- or anti-tumourigenic effect depending on the cancer type. However, its effect in intrahepatic carcinoma (ICC) remains unknown. Therefore, this study aimed to investigate the relationship between CAV1 in CAFs and tumour-infiltrating lymphocyte (TIL) numbers or PD-L1 levels in ICC patients.Consecutive ICC patients (n = 158) were enrolled in this study. The levels of CAV1 in CAFs, CD8 + TILs, Foxp3+ TILs and PD-L1 in cancer cells were analysed using immunohistochemistry. Their association with the clinicopathological factors and prognosis were evaluated. The correlation between these factors was evaluated.CAV1 upregulation in CAFs was associated with a poor overall survival (OS) (P < 0.001) and recurrence-free survival (P = 0.008). Clinicopathological factors were associated with high CA19-9 levels (P < 0.001), advanced tumour stage (P = 0.046) and lymph node metastasis (P = 0.004). CAV1 level was positively correlated with Foxp3+ TIL numbers (P = 0.01). There were no significant correlations between CAV1 levels and CD8 + TIL numbers (P = 0.80) and PD-L1 levels (P = 0.97). An increased CD8 + TIL number and decreased Foxp3+ TIL number were associated with an increased OS. In multivariate analysis, positive CAV1 expression in CAFs (P = 0.013) and decreased CD8 + TIL numbers (P = 0.021) were independent poor prognostic factors.Cellular senescence, represented by CAV1 levels, may be a marker of CAFs and a prognostic indicator of ICC through Foxp3+ TIL regulation. CAV1 expression in CAFs can be a therapeutic target for ICC." @default.
• W3202514982 created "2021-10-11" @default.
• W3202514982 creator A5011375145 @default.
• W3202514982 creator A5024376962 @default.
• W3202514982 creator A5037140284 @default.
• W3202514982 creator A5037162068 @default.
• W3202514982 creator A5048160617 @default.
• W3202514982 creator A5052033113 @default.
• W3202514982 creator A5057146510 @default.
• W3202514982 creator A5062022557 @default.
• W3202514982 creator A5065313091 @default.
• W3202514982 creator A5066213912 @default.
• W3202514982 creator A5088590521 @default.
• W3202514982 date "2021-10-06" @default.
• W3202514982 modified "2023-10-16" @default.
• W3202514982 title "Cancer-associated fibroblast senescence and its relation with tumour-infiltrating lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma" @default.
• W3202514982 cites W1463519430 @default.
• W3202514982 cites W1503705946 @default.
• W3202514982 cites W1516891040 @default.
• W3202514982 cites W1868820697 @default.
• W3202514982 cites W1889335134 @default.
• W3202514982 cites W1963570372 @default.
• W3202514982 cites W1978225946 @default.
• W3202514982 cites W1988671179 @default.
• W3202514982 cites W1995481385 @default.
• W3202514982 cites W2002879831 @default.
• W3202514982 cites W2016802652 @default.
• W3202514982 cites W2027659803 @default.
• W3202514982 cites W2032128015 @default.
• W3202514982 cites W2034770797 @default.
• W3202514982 cites W2039123767 @default.
• W3202514982 cites W2044339772 @default.
• W3202514982 cites W2048253455 @default.
• W3202514982 cites W2057373485 @default.
• W3202514982 cites W2057690410 @default.
• W3202514982 cites W2060934232 @default.
• W3202514982 cites W2061556000 @default.
• W3202514982 cites W2062809449 @default.
• W3202514982 cites W2065634756 @default.
• W3202514982 cites W2080660536 @default.
• W3202514982 cites W2086834665 @default.
• W3202514982 cites W2092296126 @default.
• W3202514982 cites W2092437783 @default.
• W3202514982 cites W2093151393 @default.
• W3202514982 cites W2093350606 @default.
• W3202514982 cites W2102718798 @default.
• W3202514982 cites W2103735571 @default.
• W3202514982 cites W2115852450 @default.
• W3202514982 cites W2120431466 @default.
• W3202514982 cites W2126369766 @default.
• W3202514982 cites W2130458932 @default.
• W3202514982 cites W2139325323 @default.
• W3202514982 cites W2141078344 @default.
• W3202514982 cites W2400022769 @default.
• W3202514982 cites W2512899508 @default.
• W3202514982 cites W2593800364 @default.
• W3202514982 cites W2763637453 @default.
• W3202514982 cites W2767473306 @default.
• W3202514982 cites W2773307121 @default.
• W3202514982 cites W2774849155 @default.
• W3202514982 cites W2809125618 @default.
• W3202514982 cites W2912724309 @default.
• W3202514982 cites W2915673227 @default.
• W3202514982 cites W3005605254 @default.
• W3202514982 cites W4211025847 @default.
• W3202514982 doi "https://doi.org/10.1038/s41416-021-01569-6" @default.
• W3202514982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34616011" @default.
• W3202514982 hasPublicationYear "2021" @default.
• W3202514982 type Work @default.
• W3202514982 sameAs 3202514982 @default.
• W3202514982 citedByCount "12" @default.
• W3202514982 countsByYear W32025149822022 @default.
• W3202514982 countsByYear W32025149822023 @default.
• W3202514982 crossrefType "journal-article" @default.
• W3202514982 hasAuthorship W3202514982A5011375145 @default.
• W3202514982 hasAuthorship W3202514982A5024376962 @default.
• W3202514982 hasAuthorship W3202514982A5037140284 @default.
• W3202514982 hasAuthorship W3202514982A5037162068 @default.
• W3202514982 hasAuthorship W3202514982A5048160617 @default.
• W3202514982 hasAuthorship W3202514982A5052033113 @default.
• W3202514982 hasAuthorship W3202514982A5057146510 @default.
• W3202514982 hasAuthorship W3202514982A5062022557 @default.
• W3202514982 hasAuthorship W3202514982A5065313091 @default.
• W3202514982 hasAuthorship W3202514982A5066213912 @default.
• W3202514982 hasAuthorship W3202514982A5088590521 @default.
• W3202514982 hasBestOaLocation W32025149822 @default.
• W3202514982 hasConcept C121608353 @default.
• W3202514982 hasConcept C126322002 @default.
• W3202514982 hasConcept C142724271 @default.
• W3202514982 hasConcept C143998085 @default.
• W3202514982 hasConcept C167672396 @default.
• W3202514982 hasConcept C203014093 @default.
• W3202514982 hasConcept C204232928 @default.
• W3202514982 hasConcept C2776107976 @default.
• W3202514982 hasConcept C2777701055 @default.
• W3202514982 hasConcept C2778326572 @default.
• W3202514982 hasConcept C2779727006 @default.
• W3202514982 hasConcept C2909706936 @default.

• next