FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202531487> ?p ?o ?g. }

• W3202531487 endingPage "5911" @default.
• W3202531487 startingPage "5911" @default.
• W3202531487 abstract "A focused series of substituted 4H-1,2,6-thiadiazin-4-ones was designed and synthesized to probe the anti-cancer properties of this scaffold. Insights from previous kinase inhibitor programs were used to carefully select several different substitution patterns. Compounds were tested on bladder, prostate, pancreatic, breast, chordoma, and lung cancer cell lines with an additional skin fibroblast cell line as a toxicity control. This resulted in the identification of several low single digit micro molar compounds with promising therapeutic windows, particularly for bladder and prostate cancer. A number of key structural features of the 4H-1,2,6-thiadiazin-4-one scaffold are discussed that show promising scope for future improvement." @default.
• W3202531487 created "2021-10-11" @default.
• W3202531487 creator A5000627767 @default.
• W3202531487 creator A5005406285 @default.
• W3202531487 creator A5032189841 @default.
• W3202531487 creator A5047612906 @default.
• W3202531487 creator A5066409069 @default.
• W3202531487 creator A5068735121 @default.
• W3202531487 creator A5074104547 @default.
• W3202531487 creator A5078651083 @default.
• W3202531487 creator A5085675603 @default.
• W3202531487 creator A5089325052 @default.
• W3202531487 date "2021-09-29" @default.
• W3202531487 modified "2023-09-23" @default.
• W3202531487 title "Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors" @default.
• W3202531487 cites W1191502296 @default.
• W3202531487 cites W1918079945 @default.
• W3202531487 cites W1957748588 @default.
• W3202531487 cites W1966285532 @default.
• W3202531487 cites W1967408251 @default.
• W3202531487 cites W1969181282 @default.
• W3202531487 cites W1981095981 @default.
• W3202531487 cites W1983643278 @default.
• W3202531487 cites W1992849882 @default.
• W3202531487 cites W2000837423 @default.
• W3202531487 cites W2009394026 @default.
• W3202531487 cites W2013432761 @default.
• W3202531487 cites W2014582878 @default.
• W3202531487 cites W2020928902 @default.
• W3202531487 cites W2026771955 @default.
• W3202531487 cites W2030102504 @default.
• W3202531487 cites W2031798894 @default.
• W3202531487 cites W2042553090 @default.
• W3202531487 cites W2049288755 @default.
• W3202531487 cites W2051835565 @default.
• W3202531487 cites W2059627263 @default.
• W3202531487 cites W2064402029 @default.
• W3202531487 cites W2077478539 @default.
• W3202531487 cites W2086286404 @default.
• W3202531487 cites W2088344132 @default.
• W3202531487 cites W2090852651 @default.
• W3202531487 cites W2110791536 @default.
• W3202531487 cites W2117954619 @default.
• W3202531487 cites W2126893023 @default.
• W3202531487 cites W2128968466 @default.
• W3202531487 cites W2140869739 @default.
• W3202531487 cites W2154055114 @default.
• W3202531487 cites W2165575701 @default.
• W3202531487 cites W2168102484 @default.
• W3202531487 cites W2169863019 @default.
• W3202531487 cites W2310460235 @default.
• W3202531487 cites W2320806079 @default.
• W3202531487 cites W2341937199 @default.
• W3202531487 cites W2343560051 @default.
• W3202531487 cites W2539333586 @default.
• W3202531487 cites W2745142516 @default.
• W3202531487 cites W2751413122 @default.
• W3202531487 cites W2773242491 @default.
• W3202531487 cites W2775428220 @default.
• W3202531487 cites W2790440100 @default.
• W3202531487 cites W2803949356 @default.
• W3202531487 cites W2804400939 @default.
• W3202531487 cites W2883658686 @default.
• W3202531487 cites W2888349794 @default.
• W3202531487 cites W2937303790 @default.
• W3202531487 cites W2940292178 @default.
• W3202531487 cites W2949677600 @default.
• W3202531487 cites W2950275047 @default.
• W3202531487 cites W2951428751 @default.
• W3202531487 cites W2958332031 @default.
• W3202531487 cites W2969359604 @default.
• W3202531487 cites W3010473282 @default.
• W3202531487 cites W3034154493 @default.
• W3202531487 cites W3112533872 @default.
• W3202531487 cites W3119588688 @default.
• W3202531487 cites W3123446037 @default.
• W3202531487 cites W3156176881 @default.
• W3202531487 cites W3157061912 @default.
• W3202531487 cites W3177828909 @default.
• W3202531487 cites W3189949217 @default.
• W3202531487 cites W4230127350 @default.
• W3202531487 cites W2762326917 @default.
• W3202531487 doi "https://doi.org/10.3390/molecules26195911" @default.
• W3202531487 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8513058" @default.
• W3202531487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641454" @default.
• W3202531487 hasPublicationYear "2021" @default.
• W3202531487 type Work @default.
• W3202531487 sameAs 3202531487 @default.
• W3202531487 citedByCount "4" @default.
• W3202531487 countsByYear W32025314872022 @default.
• W3202531487 crossrefType "journal-article" @default.
• W3202531487 hasAuthorship W3202531487A5000627767 @default.
• W3202531487 hasAuthorship W3202531487A5005406285 @default.
• W3202531487 hasAuthorship W3202531487A5032189841 @default.
• W3202531487 hasAuthorship W3202531487A5047612906 @default.
• W3202531487 hasAuthorship W3202531487A5066409069 @default.
• W3202531487 hasAuthorship W3202531487A5068735121 @default.
• W3202531487 hasAuthorship W3202531487A5074104547 @default.

• next