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- W3202648866 endingPage "170671" @default.
- W3202648866 startingPage "170671" @default.
- W3202648866 abstract "Major histocompatibility complex (MHC)-associated peptides generated and displayed by antigen-presenting cells in the thymus are essential for the generation of functional and self-tolerant T cells that protect our body from various pathogens. The peptides displayed by cortical thymic epithelial cells (cTECs) are generated by unique enzymatic machineries including the thymoproteasomes, and are involved in the positive selection of self-protective T cells. On the other hand, the peptides displayed by medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) are involved in further selection to establish self-tolerance in T cells. Although the biochemical nature of the peptide repertoire displayed in the thymus remains unclear, many studies have suggested a thymus-specific mechanism for the generation of MHC-associated peptides in the thymus. In this review, we summarize basic knowledge and recent advances in MHC-associated thymic peptides, focusing on the generation and function of thymoproteasome-dependent peptides specifically displayed by cTECs." @default.
- W3202648866 created "2021-10-11" @default.
- W3202648866 creator A5001318936 @default.
- W3202648866 creator A5077528038 @default.
- W3202648866 creator A5086413249 @default.
- W3202648866 date "2021-12-01" @default.
- W3202648866 modified "2023-09-28" @default.
- W3202648866 title "Peptides for T cell selection in the thymus" @default.
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- W3202648866 doi "https://doi.org/10.1016/j.peptides.2021.170671" @default.
- W3202648866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34624431" @default.
- W3202648866 hasPublicationYear "2021" @default.
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