FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202652904> ?p ?o ?g. }

• W3202652904 endingPage "1482" @default.
• W3202652904 startingPage "1472" @default.
• W3202652904 abstract "This study aimed to investigate whether electroacupuncture (EA) promotes the survival and synaptic plasticity of hippocampal neurons by activating brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase (TrkB)/extracellular signal-regulated kinase (Erk) signaling, thereby improving spatial memory deficits in rats under SD.In vivo, Morris water maze (MWM) was used to detect the effect of EA on learning and memory, at the same time Western blotting (WB), immunofluorescence (IF), and transmission electron microscopy (TEM) were used to explore the plasticity of hippocampal neurons and synapses, and the expression of BDNF/TrkB/Erk signaling. In vitro, cultured hippocampal neurons were treated with exogenous BDNF and the TrkB inhibitor K252a to confirm the relationship between BDNF/TrkB/Erk signaling and synaptic plasticity.Our results showed that EA mitigated the loss of hippocampal neurons and synapses, stimulated hippocampal neurogenesis, and improved learning and memory of rats under SD accompanied by upregulation of BDNF and increased phosphorylation of TrkB and Erk. In cultured hippocampal neurons, exogenous BDNF enhanced the expression of synaptic proteins, the frequency of the postsynaptic currents, and the phosphorylation of TrkB and Erk; these effects were reversed by treatment with K252a.Electroacupuncture alleviates SD-induced spatial memory impairment by promoting hippocampal neurogenesis and synaptic plasticity via activation of BDNF/TrkB/Erk signaling, which provided evidence for EA as a therapeutic strategy for countering the adverse effects of SD on cognition." @default.
• W3202652904 created "2021-10-11" @default.
• W3202652904 creator A5012040485 @default.
• W3202652904 creator A5022022526 @default.
• W3202652904 creator A5029340602 @default.
• W3202652904 creator A5031187446 @default.
• W3202652904 creator A5034762017 @default.
• W3202652904 creator A5049017087 @default.
• W3202652904 creator A5054140621 @default.
• W3202652904 creator A5055800649 @default.
• W3202652904 creator A5074604425 @default.
• W3202652904 creator A5075072013 @default.
• W3202652904 creator A5077324898 @default.
• W3202652904 creator A5086134450 @default.
• W3202652904 creator A5089917018 @default.
• W3202652904 date "2021-10-08" @default.
• W3202652904 modified "2023-10-14" @default.
• W3202652904 title "Electroacupuncture promotes the survival and synaptic plasticity of hippocampal neurons and improvement of sleep deprivation‐induced spatial memory impairment" @default.
• W3202652904 cites W150360495 @default.
• W3202652904 cites W1545533518 @default.
• W3202652904 cites W1549632147 @default.
• W3202652904 cites W1583775860 @default.
• W3202652904 cites W1755462224 @default.
• W3202652904 cites W1825797577 @default.
• W3202652904 cites W1887515971 @default.
• W3202652904 cites W1964223615 @default.
• W3202652904 cites W1968745677 @default.
• W3202652904 cites W1973159860 @default.
• W3202652904 cites W1974476511 @default.
• W3202652904 cites W1988866946 @default.
• W3202652904 cites W1990962744 @default.
• W3202652904 cites W1996414800 @default.
• W3202652904 cites W2000209446 @default.
• W3202652904 cites W2001484935 @default.
• W3202652904 cites W2004781736 @default.
• W3202652904 cites W2012423618 @default.
• W3202652904 cites W2027048265 @default.
• W3202652904 cites W2027973075 @default.
• W3202652904 cites W2040622315 @default.
• W3202652904 cites W2043482785 @default.
• W3202652904 cites W2045459271 @default.
• W3202652904 cites W2050938473 @default.
• W3202652904 cites W2055380229 @default.
• W3202652904 cites W2056769976 @default.
• W3202652904 cites W2075732211 @default.
• W3202652904 cites W2084595451 @default.
• W3202652904 cites W2085685373 @default.
• W3202652904 cites W2086155425 @default.
• W3202652904 cites W2090057913 @default.
• W3202652904 cites W2096500024 @default.
• W3202652904 cites W2108898741 @default.
• W3202652904 cites W2119184935 @default.
• W3202652904 cites W2135046848 @default.
• W3202652904 cites W2138910339 @default.
• W3202652904 cites W2139565721 @default.
• W3202652904 cites W2141021401 @default.
• W3202652904 cites W2154727263 @default.
• W3202652904 cites W2158506678 @default.
• W3202652904 cites W2168267944 @default.
• W3202652904 cites W2325449366 @default.
• W3202652904 cites W2389372316 @default.
• W3202652904 cites W2518307403 @default.
• W3202652904 cites W2728957489 @default.
• W3202652904 cites W2767724659 @default.
• W3202652904 cites W2895691332 @default.
• W3202652904 cites W2896529113 @default.
• W3202652904 cites W2909373092 @default.
• W3202652904 cites W2944984212 @default.
• W3202652904 cites W2952223286 @default.
• W3202652904 cites W2970865523 @default.
• W3202652904 cites W2979295684 @default.
• W3202652904 cites W2979714235 @default.
• W3202652904 cites W2980039635 @default.
• W3202652904 cites W2996733010 @default.
• W3202652904 cites W3042372355 @default.
• W3202652904 cites W3047879827 @default.
• W3202652904 cites W3090619216 @default.
• W3202652904 cites W3130052667 @default.
• W3202652904 cites W3202652904 @default.
• W3202652904 cites W4238754411 @default.
• W3202652904 cites W4293156776 @default.
• W3202652904 doi "https://doi.org/10.1111/cns.13722" @default.
• W3202652904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8611786" @default.
• W3202652904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34623740" @default.
• W3202652904 hasPublicationYear "2021" @default.
• W3202652904 type Work @default.
• W3202652904 sameAs 3202652904 @default.
• W3202652904 citedByCount "16" @default.
• W3202652904 countsByYear W32026529042021 @default.
• W3202652904 countsByYear W32026529042022 @default.
• W3202652904 countsByYear W32026529042023 @default.
• W3202652904 crossrefType "journal-article" @default.
• W3202652904 hasAuthorship W3202652904A5012040485 @default.
• W3202652904 hasAuthorship W3202652904A5022022526 @default.
• W3202652904 hasAuthorship W3202652904A5029340602 @default.
• W3202652904 hasAuthorship W3202652904A5031187446 @default.
• W3202652904 hasAuthorship W3202652904A5034762017 @default.
• W3202652904 hasAuthorship W3202652904A5049017087 @default.

• next