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- W3202678049 abstract "Future Medicinal ChemistryVol. 13, No. 21 CommentaryThe role of HGF/MET in liver cancerGaurav Gupta, Waleed Hassan Al-Malki, Imran Kazmi, Lakshmi Thangavelu, Piyush Kumar Gupta, Niraj Kumar Jha, Parteek Prasher, Sachin Kumar Singh & Kamal DuaGaurav Gupta *Author for correspondence: E-mail Address: gauravpharma25@gmail.comhttps://orcid.org/0000-0001-7941-0229Department of Pharmacology, School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, 302017, Jagatpura, Jaipur, IndiaSearch for more papers by this author, Waleed Hassan Al-Malki https://orcid.org/0000-0003-2584-8510Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaSearch for more papers by this author, Imran Kazmi https://orcid.org/0000-0002-6272-1976Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaSearch for more papers by this author, Lakshmi Thangavelu https://orcid.org/0000-0001-5662-1410Department of Pharmacology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, IndiaSearch for more papers by this author, Piyush Kumar Gupta https://orcid.org/0000-0002-3346-910XDepartment of Life Sciences,School of Basic Sciences and Research, Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, IndiaSearch for more papers by this author, Niraj Kumar Jha https://orcid.org/0000-0001-9486-4069Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Plot No. 32–34, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, IndiaSearch for more papers by this author, Parteek Prasher https://orcid.org/0000-0002-9412-9424Department of Chemistry, University of Petroleum & Energy Studies, Dehradun, 248007, IndiaSearch for more papers by this author, Sachin Kumar Singh https://orcid.org/0000-0003-3823-6572School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, IndiaSearch for more papers by this author & Kamal Dua https://orcid.org/0000-0002-7507-1159Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, AustraliaFaculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, AustraliaSearch for more papers by this authorPublished Online:27 Sep 2021https://doi.org/10.4155/fmc-2021-0128AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: epigenetic changeshepatocellular carcinomahepatocyte growth factormesenchymal–epithelial transitiontumor suppressor genetyrosine kinase inhibitorsReferences1. Qiu W, Chang Y, Liu J et al. Identification of P-Rex1 in the regulation of liver cancer cell proliferation and migration via HGF/c-Met/Akt pathway. Onco. Targets Ther. 13, 9481–9495 (2020).Crossref, Medline, CAS, Google Scholar2. Qian J, Liu J, Hong L et al. Upregulation of PDGF mediates robust liver regeneration after nanosecond pulsed electric field ablation by promoting the HGF/c-Met pathway. Biomed. Res. Int. 2020, 3635787 (2020).Crossref, Medline, Google Scholar3. Addante A, Roncero C, Lazcanoiturburu N et al. A signaling crosstalk between BMP9 and HGF/c-Met regulates mouse adult liver progenitor cell survival. Cells 9(3), 752 (2020).Crossref, CAS, Google Scholar4. Fu R, Jiang S, Li J, Chen H, Zhang X. Activation of the HGF/c-MET axis promotes lenvatinib resistance in hepatocellular carcinoma cells with high c-MET expression. Med. Oncol. 37(4), 24 (2020).Crossref, Medline, CAS, Google Scholar5. Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy 15(7), 1258–1279 (2019).Crossref, Medline, CAS, Google Scholar6. Huang X, Chen Z, Zhang N et al. Increase in CD4+ FOXP3+ regulatory T cell number and upregulation of the HGF/c-Met signaling pathway during the liver metastasis of colorectal cancer. Oncol. Lett. 20(3), 2113–2118 (2020).Crossref, Medline, CAS, Google Scholar7. Huang X, Zhang G, Bai X, Liang T. Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective. Oncoimmunology 9(1), 1818438 (2020).Crossref, Medline, Google Scholar8. Rizvi S, Gores GJ. Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology 145(6), 1215–1229 (2013).Crossref, Medline, CAS, Google Scholar9. Jiao D, Chen J, Li Y et al. miR-1-3p and miR-206 sensitizes HGF-induced gefitinib-resistant human lung cancer cells through inhibition of c-Met signalling and EMT. J. Cell. Mol. 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J. 476(10), 1419–1431 (2019).Crossref, Medline, CAS, Google Scholar14. Yao JF, Li XJ, Yan LK et al. Role of HGF/c-Met in the treatment of colorectal cancer with liver metastasis. J. Biochem. Mol. Toxicol. 33(6), e22316 (2019).Crossref, Medline, Google Scholar15. Zhang H, Deng T, Liu R et al. Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis. Nat. Commun. 8, 15016 (2017).Crossref, Medline, CAS, Google Scholar16. Liu J, Pan G, Liang T, Huang P. HGF/c-Met signaling mediated mesenchymal stem cell-induced liver recovery in intestinal ischemia reperfusion model. Int. J. Med. Sci. 11(6), 626–633 (2014).Crossref, Medline, Google Scholar17. Zhao M, Wang Y, Liu Y et al. C7 peptide inhibits hepatocellular carcinoma metastasis by targeting the HGF/c-Met signaling pathway. Cancer Biol. Ther. 20(12), 1430–1442 (2019).Crossref, Medline, CAS, Google Scholar18. Nakayama M, Sakai K, Yamashita A, Nakamura T, Suzuki Y, Matsumoto K. Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes. Cytokine 62(3), 446–452 (2013).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 13, No. 21 Follow us on social media for the latest updates Metrics Downloaded 102 times History Received 1 May 2021 Accepted 31 August 2021 Published online 27 September 2021 Published in print November 2021 Information© 2021 Newlands PressKeywordsepigenetic changeshepatocellular carcinomahepatocyte growth factormesenchymal–epithelial transitiontumor suppressor genetyrosine kinase inhibitorsFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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