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• W3202682008 abstract "Abstract Studies on the development of central nervous system (CNS) primarily rely on the use of specific molecular markers for different types of neural cells. S100B is widely being used as a specific marker for astrocytes in the CNS. However, the specificity of its expression in astrocyte lineage has not been systematically investigated and thus has remained a lingering issue. In this study, we provide several lines of molecular and genetic evidences that S100B is expressed in both protoplasmic astrocytes and myelinating oligodendrocytes. In the developing spinal cord, S100B is first expressed in the ventral neuroepithelial cells, and later in ALDH1L1+/GS+ astrocytes in the gray matter. Meanwhile, nearly all the S100B+ cells in the white matter are SOX10+/MYRF+ oligodendrocytes. Consistent with this observation, S100B expression is selectively lost in the white matter in Olig2 -null mutants in which oligodendrocyte progenitor cells (OPCs) are not produced, and dramatically reduced in Myrf -conditional knockout mutants in which OPCs fail to differentiate. Similar expression patterns of S100B are observed in the developing forebrain. Based on these molecular and genetic studies, we conclude that S100B is not a specific marker for astrocyte lineage; instead, it marks protoplasmic astrocytes in the gray matter and differentiating oligodendrocytes." @default.
• W3202682008 created "2021-10-11" @default.
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• W3202682008 date "2021-10-06" @default.
• W3202682008 modified "2023-10-16" @default.
• W3202682008 title "S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS" @default.
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• W3202682008 doi "https://doi.org/10.1186/s13041-021-00865-9" @default.
• W3202682008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8496084" @default.
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