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• W3202682482 abstract "Chimeric antigen receptors (CARs) are synthetic receptors that redirect T-Cell specificity, function and persistence. CARs are composed of the antigen specific region of an antibody single chain fragment (scFv) fused to the T-cells activating domain (CD3ζ) and a co-stimulatory domain (CD28ζ or 4-1BBζ). CAR-T cells promote antigen specific activation and enhance proliferation and anti-apoptotic functions (June, 2018). Tonic signalling can be defined as constitutive activation of T-Cells in the absence of a ligand." @default.
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• W3202682482 date "2021-09-01" @default.
• W3202682482 modified "2023-09-27" @default.
• W3202682482 title "36P In-vitro tonic signalling profiling of CAR-T cells generated to support pre-clinical studies for solid tumour targets" @default.
• W3202682482 doi "https://doi.org/10.1016/j.annonc.2021.08.314" @default.
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