FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202699628> ?p ?o ?g. }

• W3202699628 abstract "ABSTRACT Cherubism (CBM), characterized by expansile jawbones with multilocular fibrocystic lesions, is caused by gain‐of‐function mutations in SH3 domain‐binding protein 2 ( SH3BP2 ; mouse orthologue Sh3bp2 ). Loss of jawbone and dental integrity significantly decrease the quality of life for affected children. Treatment for CBM is limited to multiple surgeries to correct facial deformities. Despite significant advances made with CBM knockin (KI) mouse models ( Sh3bp2 KI/KI ), the activation mechanisms of CBM lesions remain unknown because mutant mice do not spontaneously develop expansile jawbones. We hypothesize that bony inflammation of an unknown cause triggers jawbone expansion in CBM. To introduce jawbone inflammation in a spatiotemporally controlled manner, we exposed pulp of the first right mandibular molar of 6‐week‐old Sh3bp2 +/+ , Sh3bp2 KI/+ , and Sh3bp2 KI/KI mice. Bacterial invasion from the exposed pulp into root canals led to apical periodontitis in wild‐type and mutant mice. The pathogen‐associated molecular patterns (PAMPs)‐induced inflammation of alveolar bone resulted in jawbone expansion in Sh3bp2 KI/+ and Sh3bp2 KI/KI mice. CBM‐like lesions developed exacerbated inflammation with increased neutrophil, macrophage, and osteoclast numbers. These lesions displayed excessive neutrophil extracellular traps (NETs) compared to Sh3bp2 +/+ mice. Expression levels of IL‐1β , IL‐6 , and TNF‐α were increased in periapical lesions of Sh3bp2 +/+ , Sh3bp2 KI/+ , and Sh3bp2 KI/KI mice and also in plasma and the left untreated mandibles (with no pulp exposure) of Sh3bp2 KI/KI mice, suggesting a systemic upregulation. Ablation of Tlr2/4 signaling or depletion of neutrophils by Ly6G antibodies ameliorated jawbone expansion induced by PAMPs in Sh3bp2 KI/KI mice. In summary, successful induction of CBM‐like lesions in jaws of CBM mice is important for studying initiating mechanisms of CBM and for testing potential therapies. Our findings further emphasize a critical role of host immunity in the development of apical periodontitis and the importance of maintaining oral health in CBM patients. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research." @default.
• W3202699628 created "2021-10-11" @default.
• W3202699628 creator A5006498055 @default.
• W3202699628 creator A5008308268 @default.
• W3202699628 creator A5017137022 @default.
• W3202699628 creator A5018186539 @default.
• W3202699628 creator A5027485050 @default.
• W3202699628 creator A5030786571 @default.
• W3202699628 creator A5080336977 @default.
• W3202699628 creator A5085709514 @default.
• W3202699628 date "2021-10-30" @default.
• W3202699628 modified "2023-09-25" @default.
• W3202699628 title "Tlr2/4‐mediated Hyperinflammation Promotes Cherubism‐like Jawbone Expansion in Sh3bp2 ( P416R ) Knockin Mice" @default.
• W3202699628 cites W1489733444 @default.
• W3202699628 cites W1920052832 @default.
• W3202699628 cites W1944352258 @default.
• W3202699628 cites W1965915060 @default.
• W3202699628 cites W1982402871 @default.
• W3202699628 cites W1986153051 @default.
• W3202699628 cites W1987379074 @default.
• W3202699628 cites W1995500501 @default.
• W3202699628 cites W2000706998 @default.
• W3202699628 cites W2007493927 @default.
• W3202699628 cites W2010128531 @default.
• W3202699628 cites W2012911819 @default.
• W3202699628 cites W2014097067 @default.
• W3202699628 cites W2020066699 @default.
• W3202699628 cites W2027378546 @default.
• W3202699628 cites W2033753616 @default.
• W3202699628 cites W2041674860 @default.
• W3202699628 cites W2042851093 @default.
• W3202699628 cites W2043756611 @default.
• W3202699628 cites W2044748328 @default.
• W3202699628 cites W2054243858 @default.
• W3202699628 cites W2055132644 @default.
• W3202699628 cites W2068014629 @default.
• W3202699628 cites W2088819153 @default.
• W3202699628 cites W2104934425 @default.
• W3202699628 cites W2109491705 @default.
• W3202699628 cites W2127403047 @default.
• W3202699628 cites W2137271664 @default.
• W3202699628 cites W2142194813 @default.
• W3202699628 cites W2148607491 @default.
• W3202699628 cites W2148872227 @default.
• W3202699628 cites W2167798404 @default.
• W3202699628 cites W2418687434 @default.
• W3202699628 cites W2534772180 @default.
• W3202699628 cites W2550084246 @default.
• W3202699628 cites W2942968847 @default.
• W3202699628 cites W2981742381 @default.
• W3202699628 cites W3080253995 @default.
• W3202699628 cites W51001929 @default.
• W3202699628 doi "https://doi.org/10.1002/jbm4.10562" @default.
• W3202699628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35079675" @default.
• W3202699628 hasPublicationYear "2021" @default.
• W3202699628 type Work @default.
• W3202699628 sameAs 3202699628 @default.
• W3202699628 citedByCount "0" @default.
• W3202699628 crossrefType "journal-article" @default.
• W3202699628 hasAuthorship W3202699628A5006498055 @default.
• W3202699628 hasAuthorship W3202699628A5008308268 @default.
• W3202699628 hasAuthorship W3202699628A5017137022 @default.
• W3202699628 hasAuthorship W3202699628A5018186539 @default.
• W3202699628 hasAuthorship W3202699628A5027485050 @default.
• W3202699628 hasAuthorship W3202699628A5030786571 @default.
• W3202699628 hasAuthorship W3202699628A5080336977 @default.
• W3202699628 hasAuthorship W3202699628A5085709514 @default.
• W3202699628 hasBestOaLocation W32026996281 @default.
• W3202699628 hasConcept C104317684 @default.
• W3202699628 hasConcept C126322002 @default.
• W3202699628 hasConcept C127561419 @default.
• W3202699628 hasConcept C142724271 @default.
• W3202699628 hasConcept C188442228 @default.
• W3202699628 hasConcept C203014093 @default.
• W3202699628 hasConcept C2776070231 @default.
• W3202699628 hasConcept C2776914184 @default.
• W3202699628 hasConcept C2777134543 @default.
• W3202699628 hasConcept C2780385504 @default.
• W3202699628 hasConcept C2781236682 @default.
• W3202699628 hasConcept C55493867 @default.
• W3202699628 hasConcept C71924100 @default.
• W3202699628 hasConcept C77076574 @default.
• W3202699628 hasConcept C86803240 @default.
• W3202699628 hasConceptScore W3202699628C104317684 @default.
• W3202699628 hasConceptScore W3202699628C126322002 @default.
• W3202699628 hasConceptScore W3202699628C127561419 @default.
• W3202699628 hasConceptScore W3202699628C142724271 @default.
• W3202699628 hasConceptScore W3202699628C188442228 @default.
• W3202699628 hasConceptScore W3202699628C203014093 @default.
• W3202699628 hasConceptScore W3202699628C2776070231 @default.
• W3202699628 hasConceptScore W3202699628C2776914184 @default.
• W3202699628 hasConceptScore W3202699628C2777134543 @default.
• W3202699628 hasConceptScore W3202699628C2780385504 @default.
• W3202699628 hasConceptScore W3202699628C2781236682 @default.
• W3202699628 hasConceptScore W3202699628C55493867 @default.
• W3202699628 hasConceptScore W3202699628C71924100 @default.
• W3202699628 hasConceptScore W3202699628C77076574 @default.
• W3202699628 hasConceptScore W3202699628C86803240 @default.
• W3202699628 hasFunder F4320332161 @default.
• W3202699628 hasFunder F4320337365 @default.

• next