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- W3202700617 abstract "Several onco-virotherapy candidates have been developed and clinically evaluated for the treatment of cancer, and several are approved for clinical use. In this systematic review we explored the clinical impact of onco-virotherapy compared to other cancer therapies by analyzing factors such as trial design, patient background, therapy design, delivery strategies, and study outcomes. For this purpose, we retrieved clinical studies from three platforms: ClinicalTrials.gov, PubMed, and EMBASE. We found that most studies were performed in patients with advanced and metastatic tumors, using a broad range of genetically engineered vectors and mainly administered intratumorally. Therapeutic safety was the most frequently assessed outcome, while relatively few studies focused on immunological antitumor responses. Moreover, only 59 out of 896 clinical studies were randomized controlled trials reporting comparative data. This systemic review thus reveals the need of more, and better controlled, clinical studies to increase our understanding on the application of onco-virotherapy either as a single treatment or in combination with other cancer immunotherapies." @default.
- W3202700617 created "2021-10-11" @default.
- W3202700617 creator A5018392015 @default.
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- W3202700617 creator A5079792318 @default.
- W3202700617 creator A5083692113 @default.
- W3202700617 creator A5085683117 @default.
- W3202700617 date "2021-12-01" @default.
- W3202700617 modified "2023-09-26" @default.
- W3202700617 title "A systematic analysis on the clinical safety and efficacy of onco-virotherapy" @default.
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- W3202700617 doi "https://doi.org/10.1016/j.omto.2021.09.008" @default.
- W3202700617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8551473" @default.
- W3202700617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34761104" @default.
- W3202700617 hasPublicationYear "2021" @default.
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