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- W3202714947 abstract "Animal models provide the link between in vitro research and the first in-man application during clinical trials. They provide substantial information in preclinical studies for the assessment of new therapeutic interventions in advance of human clinical trials. However, each model has its advantages and limitations in the ability to imitate specific pathomechanisms. Therefore, the selection of an animal model for the evaluation of a specific research question or evaluation of a novel therapeutic strategy requires a precise analysis. Transplantation research is a discipline that largely benefits from the use of animal models with mouse and pig models being the most frequently used models in organ transplantation research. A suitable animal model should reflect best the situation in humans, and the researcher should be aware of the similarities as well as the limitations of the chosen model. Small animal models with rats and mice are contributing to the majority of animal experiments with the obvious advantages of these models being easy handling, low costs, and high reproductive rates. However, unfortunately, they often do not translate to clinical use. Large animal models, especially in transplantation medicine, are an important element for establishing preclinical models that do often translate to the clinic. Nevertheless, they can be costly, present increased regulatory requirements, and often are of high ethical concern. Therefore, it is crucial to select the right animal model from which extrapolations and valid conclusions can be obtained and translated into the human situation. This review provides an overview in the models frequently used in organ transplantation research." @default.
- W3202714947 created "2021-10-11" @default.
- W3202714947 creator A5010671189 @default.
- W3202714947 creator A5035709340 @default.
- W3202714947 creator A5048193401 @default.
- W3202714947 date "2021-10-03" @default.
- W3202714947 modified "2023-09-25" @default.
- W3202714947 title "Animal Models in Allogenic Solid Organ Transplantation" @default.
- W3202714947 cites W1488681950 @default.
- W3202714947 cites W1536149929 @default.
- W3202714947 cites W1566888664 @default.
- W3202714947 cites W1579568690 @default.
- W3202714947 cites W1580674042 @default.
- W3202714947 cites W1598018958 @default.
- W3202714947 cites W1811010387 @default.
- W3202714947 cites W1977954222 @default.
- W3202714947 cites W1978803498 @default.
- W3202714947 cites W1980874133 @default.
- W3202714947 cites W1988627175 @default.
- W3202714947 cites W1989177039 @default.
- W3202714947 cites W1992637538 @default.
- W3202714947 cites W1999040116 @default.
- W3202714947 cites W2002751122 @default.
- W3202714947 cites W2008129213 @default.
- W3202714947 cites W2010959015 @default.
- W3202714947 cites W2014429062 @default.
- W3202714947 cites W2015155093 @default.
- W3202714947 cites W2023115336 @default.
- W3202714947 cites W2023919621 @default.
- W3202714947 cites W2034055535 @default.
- W3202714947 cites W2035749372 @default.
- W3202714947 cites W2042384977 @default.
- W3202714947 cites W2046364499 @default.
- W3202714947 cites W2047991924 @default.
- W3202714947 cites W2050034605 @default.
- W3202714947 cites W2059950347 @default.
- W3202714947 cites W2061914233 @default.
- W3202714947 cites W2064425521 @default.
- W3202714947 cites W2067109494 @default.
- W3202714947 cites W2070755681 @default.
- W3202714947 cites W2071611365 @default.
- W3202714947 cites W2075805404 @default.
- W3202714947 cites W2078347126 @default.
- W3202714947 cites W2078635542 @default.
- W3202714947 cites W2087777680 @default.
- W3202714947 cites W2088404295 @default.
- W3202714947 cites W2090443192 @default.
- W3202714947 cites W2090760378 @default.
- W3202714947 cites W2093636093 @default.
- W3202714947 cites W2096447978 @default.
- W3202714947 cites W2099632521 @default.
- W3202714947 cites W2103914511 @default.
- W3202714947 cites W2106394409 @default.
- W3202714947 cites W2107008927 @default.
- W3202714947 cites W2141121572 @default.
- W3202714947 cites W2142944825 @default.
- W3202714947 cites W2143067351 @default.
- W3202714947 cites W2144069368 @default.
- W3202714947 cites W2144589914 @default.
- W3202714947 cites W2151464048 @default.
- W3202714947 cites W2154169380 @default.
- W3202714947 cites W2158692387 @default.
- W3202714947 cites W2178360416 @default.
- W3202714947 cites W2200522016 @default.
- W3202714947 cites W2312995349 @default.
- W3202714947 cites W2314630225 @default.
- W3202714947 cites W2344533005 @default.
- W3202714947 cites W2415257173 @default.
- W3202714947 cites W2539224641 @default.
- W3202714947 cites W2770581098 @default.
- W3202714947 cites W2777434339 @default.
- W3202714947 cites W2805089634 @default.
- W3202714947 cites W2883050115 @default.
- W3202714947 cites W2887556920 @default.
- W3202714947 cites W2893918473 @default.
- W3202714947 cites W2895427826 @default.
- W3202714947 cites W2896607347 @default.
- W3202714947 cites W2938864994 @default.
- W3202714947 cites W2942299761 @default.
- W3202714947 cites W2944150047 @default.
- W3202714947 cites W2954018739 @default.
- W3202714947 cites W2966535243 @default.
- W3202714947 cites W2980630331 @default.
- W3202714947 cites W2982585099 @default.
- W3202714947 cites W2994961347 @default.
- W3202714947 cites W2995039599 @default.
- W3202714947 cites W3005900712 @default.
- W3202714947 cites W3007353392 @default.
- W3202714947 cites W3012730712 @default.
- W3202714947 cites W3023692003 @default.
- W3202714947 cites W3045048008 @default.
- W3202714947 cites W3091997492 @default.
- W3202714947 cites W3109455501 @default.
- W3202714947 cites W3124429548 @default.
- W3202714947 cites W3132850575 @default.
- W3202714947 cites W3166751735 @default.
- W3202714947 cites W3166957458 @default.
- W3202714947 cites W4206444550 @default.