FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202772783> ?p ?o ?g. }

• W3202772783 abstract "Abstract Despite the involvement of Poly(ADP-ribose) polymerase-1 (PARP1) in many important biological pathways, the target residues of PARP1-mediated ADP-ribosylation remain ambiguous. To explicate the ADP-ribosylation regulome, we analyze human cells depleted for key regulators of PARP1 activity, histone PARylation factor 1 (HPF1) and ADP-ribosylhydrolase 3 (ARH3). Using quantitative proteomics, we characterize 1,596 ADP-ribosylation sites, displaying up to 1000-fold regulation across the investigated knockout cells. We find that HPF1 and ARH3 inversely and homogenously regulate the serine ADP-ribosylome on a proteome-wide scale with consistent adherence to lysine-serine-motifs, suggesting that targeting is independent of HPF1 and ARH3. Notably, we do not detect an HPF1-dependent target residue switch from serine to glutamate/aspartate under the investigated conditions. Our data support the notion that serine ADP-ribosylation mainly exists as mono-ADP-ribosylation in cells, and reveal a remarkable degree of histone co-modification with serine ADP-ribosylation and other post-translational modifications." @default.
• W3202772783 created "2021-10-11" @default.
• W3202772783 creator A5008202070 @default.
• W3202772783 creator A5009510298 @default.
• W3202772783 creator A5021767059 @default.
• W3202772783 creator A5023236057 @default.
• W3202772783 creator A5050670577 @default.
• W3202772783 creator A5057051777 @default.
• W3202772783 creator A5058266096 @default.
• W3202772783 creator A5062885201 @default.
• W3202772783 creator A5062998210 @default.
• W3202772783 creator A5065023489 @default.
• W3202772783 date "2021-10-08" @default.
• W3202772783 modified "2023-10-15" @default.
• W3202772783 title "The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome" @default.
• W3202772783 cites W1484451637 @default.
• W3202772783 cites W1486214849 @default.
• W3202772783 cites W1494501092 @default.
• W3202772783 cites W1848063234 @default.
• W3202772783 cites W1973123264 @default.
• W3202772783 cites W1993043513 @default.
• W3202772783 cites W2003100658 @default.
• W3202772783 cites W2005458257 @default.
• W3202772783 cites W2011955349 @default.
• W3202772783 cites W2012790791 @default.
• W3202772783 cites W2020639312 @default.
• W3202772783 cites W2027968455 @default.
• W3202772783 cites W2033554372 @default.
• W3202772783 cites W2036321220 @default.
• W3202772783 cites W2045450732 @default.
• W3202772783 cites W2049216034 @default.
• W3202772783 cites W2060002498 @default.
• W3202772783 cites W2060392260 @default.
• W3202772783 cites W2072528578 @default.
• W3202772783 cites W2073371472 @default.
• W3202772783 cites W2074730941 @default.
• W3202772783 cites W2077672576 @default.
• W3202772783 cites W2080752012 @default.
• W3202772783 cites W2081320361 @default.
• W3202772783 cites W2083287362 @default.
• W3202772783 cites W2091273971 @default.
• W3202772783 cites W2106059513 @default.
• W3202772783 cites W2106390123 @default.
• W3202772783 cites W2122312191 @default.
• W3202772783 cites W2125759661 @default.
• W3202772783 cites W2132396299 @default.
• W3202772783 cites W2138576901 @default.
• W3202772783 cites W2141892726 @default.
• W3202772783 cites W2145268834 @default.
• W3202772783 cites W2158389792 @default.
• W3202772783 cites W2169274959 @default.
• W3202772783 cites W2217204947 @default.
• W3202772783 cites W2332306552 @default.
• W3202772783 cites W2334440167 @default.
• W3202772783 cites W2463195069 @default.
• W3202772783 cites W2476568892 @default.
• W3202772783 cites W2525134285 @default.
• W3202772783 cites W2530540719 @default.
• W3202772783 cites W2567339323 @default.
• W3202772783 cites W2587003776 @default.
• W3202772783 cites W2591689499 @default.
• W3202772783 cites W2624356059 @default.
• W3202772783 cites W2732346161 @default.
• W3202772783 cites W2766471599 @default.
• W3202772783 cites W2766575289 @default.
• W3202772783 cites W2766896180 @default.
• W3202772783 cites W2768216998 @default.
• W3202772783 cites W2772487490 @default.
• W3202772783 cites W2788939638 @default.
• W3202772783 cites W2887047031 @default.
• W3202772783 cites W2889423344 @default.
• W3202772783 cites W2893419667 @default.
• W3202772783 cites W2899760200 @default.
• W3202772783 cites W2949539007 @default.
• W3202772783 cites W2962710628 @default.
• W3202772783 cites W3004782200 @default.
• W3202772783 cites W3013836282 @default.
• W3202772783 cites W3039458460 @default.
• W3202772783 cites W3042168922 @default.
• W3202772783 cites W3048741258 @default.
• W3202772783 cites W3087615343 @default.
• W3202772783 cites W3088079530 @default.
• W3202772783 cites W3093017508 @default.
• W3202772783 cites W3101736589 @default.
• W3202772783 cites W3105944734 @default.
• W3202772783 cites W3134530449 @default.
• W3202772783 cites W3162472426 @default.
• W3202772783 cites W3173764271 @default.
• W3202772783 cites W4210539972 @default.
• W3202772783 cites W4247349884 @default.
• W3202772783 cites W57292768 @default.
• W3202772783 cites W913777339 @default.
• W3202772783 cites W96993440 @default.
• W3202772783 doi "https://doi.org/10.1038/s41467-021-26172-4" @default.
• W3202772783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8501107" @default.
• W3202772783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34625544" @default.
• W3202772783 hasPublicationYear "2021" @default.
• W3202772783 type Work @default.
• W3202772783 sameAs 3202772783 @default.
• W3202772783 citedByCount "33" @default.

• next