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- W3202798981 abstract "Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.Case-control data were used to compare the capacity of age, sex, and 58 Alzheimer's disease (AD)-associated single nucleotide polymorphisms (SNPs) to predict AD status using several statistical models. Model performance was assessed with Brier scores and tenfold cross-validation. Genotype and sex × age estimates from the best performing model were combined with age and intercept estimates from the general population to develop a personalized genetic risk score, termed age, and sex-adjusted GenoRisk.The elastic net model that included age, age x sex interaction, allelic APOE terms, and 29 additional SNPs performed the best. This model explained an additional 19% of the heritable risk compared to APOE genotype alone and achieved an area under the curve of 0.747.GenoRisk could improve the risk assessment of individuals identified for prevention studies." @default.
- W3202798981 created "2021-10-11" @default.
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- W3202798981 date "2021-01-01" @default.
- W3202798981 modified "2023-09-26" @default.
- W3202798981 title "GenoRisk: A polygenic risk score for Alzheimer's disease" @default.
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- W3202798981 doi "https://doi.org/10.1002/trc2.12211" @default.
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