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- W3202828663 startingPage "2089" @default.
- W3202828663 abstract "We examined the prebiotic potential of 32 food ingredients on the developing infant microbiome using an in vitro gastroileal digestion and colonic fermentation model. There were significant changes in the concentrations of short-chain fatty-acid metabolites, confirming the potential of the tested ingredients to stimulate bacterial metabolism. The 16S rRNA gene sequencing for a subset of the ingredients revealed significant increases in the relative abundances of the lactate- and acetate-producing Bifidobacteriaceae, Enterococcaceae, and Lactobacillaceae, and lactate- and acetate-utilizing Prevotellaceae, Lachnospiraceae, and Veillonellaceae. Selective changes in specific bacterial groups were observed. Infant whole-milk powder and an oat flour enhanced Bifidobacteriaceae and lactic acid bacteria. A New Zealand-origin spinach powder enhanced Prevotellaceae and Lachnospiraceae, while fruit and vegetable powders increased a mixed consortium of beneficial gut microbiota. All food ingredients demonstrated a consistent decrease in Clostridium perfringens, with this organism being increased in the carbohydrate-free water control. While further studies are required, this study demonstrates that the selected food ingredients can modulate the infant gut microbiome composition and metabolism in vitro. This approach provides an opportunity to design nutrient-rich complementary foods that fulfil infants' growth needs and support the maturation of the infant gut microbiome." @default.
- W3202828663 created "2021-10-11" @default.
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- W3202828663 date "2021-10-03" @default.
- W3202828663 modified "2023-09-26" @default.
- W3202828663 title "Complementary Food Ingredients Alter Infant Gut Microbiome Composition and Metabolism In Vitro" @default.
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- W3202828663 doi "https://doi.org/10.3390/microorganisms9102089" @default.
- W3202828663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8540059" @default.
- W3202828663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34683410" @default.
- W3202828663 hasPublicationYear "2021" @default.
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