FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202851912> ?p ?o ?g. }

• W3202851912 endingPage "395" @default.
• W3202851912 startingPage "385" @default.
• W3202851912 abstract "The epithelial-to-mesenchymal transition may play a role in adenomyosis. GRIM19 expression is downregulated in adenomyotic lesions, and the effects of this downregulation in adenomyosis remain relatively unclear. In this study, we aimed to explore whether aberrant GRIM19 expression is associated with the epithelial-to-mesenchymal transition in adenomyosis and found that the expression of both GRIM19 and WT1 was low, and epithelial-to-mesenchymal transition, which included significant changes in CDH1, CDH2 and KRT8 expression, occurred in adenomyotic lesions, as confirmed by Western blotting and quantitative real-time PCR. We provided novel insights into WT1 expression in adenomyosis, revealing that WT1 expression was increased in the endometrial glands of adenomyotic lesions by immunohistochemistry. In vitro, knockdown of GRIM19 expression by small interfering RNA (siRNA) promoted the proliferation, migration and invasion of Ishikawa cells, as measured by Cell Counting Kit-8, wound healing assay and Transwell assays. Western blotting and quantitative real-time PCR confirmed that WT1 expression increased and epithelial-to-mesenchymal transition was induced, including the upregulation of CDH2 and downregulation of CDH1 and KRT8after transfecting the GRIM19 siRNA to Ishikawa cells. Furthermore, WT1 expression was upregulated and epithelial-to-mesenchymal transition was observed, including downregulation of CDH1 and KRT8in GRIM19 gene-knockdown mice. Upregulation of Wt1 expression in the endometrial glands of Grim19 knockdown mice was also verified by immunohistochemistry. Taken together, these results reveal that low expression of GRIM19 in adenomyosis may upregulate WT1 expression and induce epithelial-to-mesenchymal transition in the endometria, providing new insights into the pathogenesis of adenomyosis." @default.
• W3202851912 created "2021-10-11" @default.
• W3202851912 creator A5039575740 @default.
• W3202851912 creator A5041938409 @default.
• W3202851912 creator A5049692788 @default.
• W3202851912 creator A5057501197 @default.
• W3202851912 creator A5082086115 @default.
• W3202851912 date "2021-11-01" @default.
• W3202851912 modified "2023-10-14" @default.
• W3202851912 title "GRIM19 is involved in WT1 expression and epithelial-to-mesenchymal transition in adenomyotic lesions" @default.
• W3202851912 cites W1988827270 @default.
• W3202851912 cites W1996517697 @default.
• W3202851912 cites W2030370569 @default.
• W3202851912 cites W2040768464 @default.
• W3202851912 cites W2066108428 @default.
• W3202851912 cites W2066594695 @default.
• W3202851912 cites W2067244501 @default.
• W3202851912 cites W2079141105 @default.
• W3202851912 cites W2082895851 @default.
• W3202851912 cites W2090954031 @default.
• W3202851912 cites W2266799016 @default.
• W3202851912 cites W2520246242 @default.
• W3202851912 cites W2791130228 @default.
• W3202851912 cites W2791240641 @default.
• W3202851912 cites W2897196381 @default.
• W3202851912 cites W2963973147 @default.
• W3202851912 cites W3002305227 @default.
• W3202851912 cites W3024114123 @default.
• W3202851912 doi "https://doi.org/10.1530/rep-21-0181" @default.
• W3202851912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34590585" @default.
• W3202851912 hasPublicationYear "2021" @default.
• W3202851912 type Work @default.
• W3202851912 sameAs 3202851912 @default.
• W3202851912 citedByCount "1" @default.
• W3202851912 countsByYear W32028519122023 @default.
• W3202851912 crossrefType "journal-article" @default.
• W3202851912 hasAuthorship W3202851912A5039575740 @default.
• W3202851912 hasAuthorship W3202851912A5041938409 @default.
• W3202851912 hasAuthorship W3202851912A5049692788 @default.
• W3202851912 hasAuthorship W3202851912A5057501197 @default.
• W3202851912 hasAuthorship W3202851912A5082086115 @default.
• W3202851912 hasBestOaLocation W32028519121 @default.
• W3202851912 hasConcept C104317684 @default.
• W3202851912 hasConcept C127561419 @default.
• W3202851912 hasConcept C142724271 @default.
• W3202851912 hasConcept C1491633281 @default.
• W3202851912 hasConcept C149402561 @default.
• W3202851912 hasConcept C153911025 @default.
• W3202851912 hasConcept C173396325 @default.
• W3202851912 hasConcept C185592680 @default.
• W3202851912 hasConcept C198826908 @default.
• W3202851912 hasConcept C204232928 @default.
• W3202851912 hasConcept C2776391639 @default.
• W3202851912 hasConcept C2779166600 @default.
• W3202851912 hasConcept C2779522080 @default.
• W3202851912 hasConcept C502942594 @default.
• W3202851912 hasConcept C54355233 @default.
• W3202851912 hasConcept C55493867 @default.
• W3202851912 hasConcept C71924100 @default.
• W3202851912 hasConcept C76419328 @default.
• W3202851912 hasConcept C81885089 @default.
• W3202851912 hasConcept C85265743 @default.
• W3202851912 hasConcept C86803240 @default.
• W3202851912 hasConcept C95444343 @default.
• W3202851912 hasConceptScore W3202851912C104317684 @default.
• W3202851912 hasConceptScore W3202851912C127561419 @default.
• W3202851912 hasConceptScore W3202851912C142724271 @default.
• W3202851912 hasConceptScore W3202851912C1491633281 @default.
• W3202851912 hasConceptScore W3202851912C149402561 @default.
• W3202851912 hasConceptScore W3202851912C153911025 @default.
• W3202851912 hasConceptScore W3202851912C173396325 @default.
• W3202851912 hasConceptScore W3202851912C185592680 @default.
• W3202851912 hasConceptScore W3202851912C198826908 @default.
• W3202851912 hasConceptScore W3202851912C204232928 @default.
• W3202851912 hasConceptScore W3202851912C2776391639 @default.
• W3202851912 hasConceptScore W3202851912C2779166600 @default.
• W3202851912 hasConceptScore W3202851912C2779522080 @default.
• W3202851912 hasConceptScore W3202851912C502942594 @default.
• W3202851912 hasConceptScore W3202851912C54355233 @default.
• W3202851912 hasConceptScore W3202851912C55493867 @default.
• W3202851912 hasConceptScore W3202851912C71924100 @default.
• W3202851912 hasConceptScore W3202851912C76419328 @default.
• W3202851912 hasConceptScore W3202851912C81885089 @default.
• W3202851912 hasConceptScore W3202851912C85265743 @default.
• W3202851912 hasConceptScore W3202851912C86803240 @default.
• W3202851912 hasConceptScore W3202851912C95444343 @default.
• W3202851912 hasIssue "5" @default.
• W3202851912 hasLocation W32028519121 @default.
• W3202851912 hasLocation W32028519122 @default.
• W3202851912 hasOpenAccess W3202851912 @default.
• W3202851912 hasPrimaryLocation W32028519121 @default.
• W3202851912 hasRelatedWork W2086968193 @default.
• W3202851912 hasRelatedWork W2150576339 @default.
• W3202851912 hasRelatedWork W2345782301 @default.
• W3202851912 hasRelatedWork W2557443381 @default.
• W3202851912 hasRelatedWork W2603579215 @default.
• W3202851912 hasRelatedWork W2885810604 @default.
• W3202851912 hasRelatedWork W2891025841 @default.

• next