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• W3202872245 abstract "Background Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has emerged as an important toxicity among patients with cancer. Methods We collected data on 429 patients with ICPi-AKI and 429 control patients who received ICPis contemporaneously but who did not develop ICPi-AKI from 30 sites in 10 countries. Multivariable logistic regression was used to identify predictors of ICPi-AKI and its recovery. A multivariable Cox model was used to estimate the effect of ICPi rechallenge versus no rechallenge on survival following ICPi-AKI. Results ICPi-AKI occurred at a median of 16 weeks (IQR 8–32) following ICPi initiation. Lower baseline estimated glomerular filtration rate, proton pump inhibitor (PPI) use, and extrarenal immune-related adverse events (irAEs) were each associated with a higher risk of ICPi-AKI. Acute tubulointerstitial nephritis was the most common lesion on kidney biopsy (125/151 biopsied patients [82.7%]). Renal recovery occurred in 276 patients (64.3%) at a median of 7 weeks (IQR 3–10) following ICPi-AKI. Treatment with corticosteroids within 14 days following ICPi-AKI diagnosis was associated with higher odds of renal recovery (adjusted OR 2.64; 95% CI 1.58 to 4.41). Among patients treated with corticosteroids, early initiation of corticosteroids (within 3 days of ICPi-AKI) was associated with a higher odds of renal recovery compared with later initiation (more than 3 days following ICPi-AKI) (adjusted OR 2.09; 95% CI 1.16 to 3.79). Of 121 patients rechallenged, 20 (16.5%) developed recurrent ICPi-AKI. There was no difference in survival among patients rechallenged versus those not rechallenged following ICPi-AKI. Conclusions Patients who developed ICPi-AKI were more likely to have impaired renal function at baseline, use a PPI, and have extrarenal irAEs. Two-thirds of patients had renal recovery following ICPi-AKI. Treatment with corticosteroids was associated with improved renal recovery." @default.
• W3202872245 created "2021-10-11" @default.
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• W3202872245 date "2021-10-01" @default.
• W3202872245 modified "2023-10-18" @default.
• W3202872245 title "Acute kidney injury in patients treated with immune checkpoint inhibitors" @default.
• W3202872245 cites W1556990476 @default.
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• W3202872245 cites W2109653150 @default.
• W3202872245 cites W2115964027 @default.
• W3202872245 cites W2128802116 @default.
• W3202872245 cites W2139937737 @default.
• W3202872245 cites W2155965977 @default.
• W3202872245 cites W2256864278 @default.
• W3202872245 cites W2338242614 @default.
• W3202872245 cites W2413514895 @default.
• W3202872245 cites W2549481046 @default.
• W3202872245 cites W2572174216 @default.
• W3202872245 cites W2607031541 @default.
• W3202872245 cites W2785542643 @default.
• W3202872245 cites W2801738147 @default.
• W3202872245 cites W2802643432 @default.
• W3202872245 cites W2914077897 @default.
• W3202872245 cites W2914287567 @default.
• W3202872245 cites W2944434778 @default.
• W3202872245 cites W2949334838 @default.
• W3202872245 cites W2984413960 @default.
• W3202872245 cites W2997561837 @default.
• W3202872245 cites W2999959360 @default.
• W3202872245 cites W3000259466 @default.
• W3202872245 cites W3005947910 @default.
• W3202872245 cites W3034894621 @default.
• W3202872245 cites W3037575240 @default.
• W3202872245 cites W3044041426 @default.
• W3202872245 cites W3045946240 @default.

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