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• W3202916477 endingPage "2597" @default.
• W3202916477 startingPage "2597" @default.
• W3202916477 abstract "Myeloproliferative neoplasms are hematologic malignancies typified by a substantial heritable component. Germline variants may affect the risk of developing a MPN, as documented by GWAS studies on large patient cohorts. In addition, once the MPN occurred, inherited host genetic factors can be responsible for tuning the disease phenotypic presentation, outcome, and response to therapy. This review covered the polymorphisms that have been variably associated to MPNs, discussing them in the functional perspective of the biological pathways involved. Finally, we reviewed host genetic determinants of clonal hematopoiesis, a pre-malignant state that may anticipate overt hematologic neoplasms including MPNs." @default.
• W3202916477 created "2021-10-11" @default.
• W3202916477 creator A5005517256 @default.
• W3202916477 creator A5049688233 @default.
• W3202916477 creator A5073789933 @default.
• W3202916477 creator A5085459773 @default.
• W3202916477 date "2021-09-29" @default.
• W3202916477 modified "2023-09-30" @default.
• W3202916477 title "The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome" @default.
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• W3202916477 doi "https://doi.org/10.3390/cells10102597" @default.

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