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- W3202923009 abstract "Synthetic nanopores made from DNA replicate the key biological processes of transporting molecular cargo across lipid bilayers. Understanding transport across the confined lumen of the nanopores is of fundamental interest and of relevance to their rational design for biotechnological applications. Here we reveal the transport principles of organic molecules through DNA nanopores by synergistically combining experiments and computer simulations. Using a highly parallel nanostructured platform, we synchronously measure the kinetic flux across hundreds of individual pores to obtain rate constants. The single-channel transport kinetics are close to the theoretical maximum, while selectivity is determined by the interplay of cargo charge and size, the pores' sterics and electrostatics, and the composition of the surrounding lipid bilayer. The narrow distribution of transport rates implies a high structural homogeneity of DNA nanopores. The molecular passageway through the nanopore is elucidated via coarse-grained constant-velocity steered molecular dynamics simulations. The ensemble simulations pinpoint with high resolution and statistical validity the selectivity filter within the channel lumen and determine the energetic factors governing transport. Our findings on these synthetic pores' structure-function relationship will serve to guide their rational engineering to tailor transport selectivity for cell biological research, sensing, and drug delivery." @default.
- W3202923009 created "2021-10-11" @default.
- W3202923009 creator A5007668889 @default.
- W3202923009 creator A5015100789 @default.
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- W3202923009 creator A5077078811 @default.
- W3202923009 creator A5089105218 @default.
- W3202923009 date "2021-10-01" @default.
- W3202923009 modified "2023-10-17" @default.
- W3202923009 title "Principles of Small-Molecule Transport through Synthetic Nanopores" @default.
- W3202923009 cites W1031578623 @default.
- W3202923009 cites W1512281481 @default.
- W3202923009 cites W1927676883 @default.
- W3202923009 cites W1964651856 @default.
- W3202923009 cites W1967952840 @default.
- W3202923009 cites W1969054046 @default.
- W3202923009 cites W1971536912 @default.
- W3202923009 cites W1974312616 @default.
- W3202923009 cites W1974655530 @default.
- W3202923009 cites W1975092516 @default.
- W3202923009 cites W1975679096 @default.
- W3202923009 cites W1982898268 @default.
- W3202923009 cites W1983080100 @default.
- W3202923009 cites W1986910511 @default.
- W3202923009 cites W1992390858 @default.
- W3202923009 cites W1993984194 @default.
- W3202923009 cites W1996685148 @default.
- W3202923009 cites W1997772366 @default.
- W3202923009 cites W2002483835 @default.
- W3202923009 cites W2004563570 @default.
- W3202923009 cites W2004656661 @default.
- W3202923009 cites W2006008435 @default.
- W3202923009 cites W2015085424 @default.
- W3202923009 cites W2020097975 @default.
- W3202923009 cites W2022251008 @default.
- W3202923009 cites W2023867834 @default.
- W3202923009 cites W2030683115 @default.
- W3202923009 cites W2043812489 @default.
- W3202923009 cites W2049120083 @default.
- W3202923009 cites W2049286183 @default.
- W3202923009 cites W2050694122 @default.
- W3202923009 cites W2052211064 @default.
- W3202923009 cites W2060433756 @default.
- W3202923009 cites W2062882464 @default.
- W3202923009 cites W2065995972 @default.
- W3202923009 cites W2069947809 @default.
- W3202923009 cites W2070753604 @default.
- W3202923009 cites W2075777353 @default.
- W3202923009 cites W2077024660 @default.
- W3202923009 cites W2088321333 @default.
- W3202923009 cites W2089675977 @default.
- W3202923009 cites W2108058966 @default.
- W3202923009 cites W2112154906 @default.
- W3202923009 cites W2119267663 @default.
- W3202923009 cites W2122742537 @default.
- W3202923009 cites W2128795881 @default.
- W3202923009 cites W2129096474 @default.
- W3202923009 cites W2141766828 @default.
- W3202923009 cites W2159992437 @default.
- W3202923009 cites W2171372763 @default.
- W3202923009 cites W2221713243 @default.
- W3202923009 cites W2235600118 @default.
- W3202923009 cites W2237123958 @default.
- W3202923009 cites W2259815689 @default.
- W3202923009 cites W2315037307 @default.
- W3202923009 cites W2327174080 @default.
- W3202923009 cites W2330741670 @default.
- W3202923009 cites W2342925174 @default.
- W3202923009 cites W2345406112 @default.
- W3202923009 cites W2394667511 @default.
- W3202923009 cites W2508730156 @default.
- W3202923009 cites W2510246319 @default.
- W3202923009 cites W2521555333 @default.
- W3202923009 cites W2549678059 @default.
- W3202923009 cites W2598856845 @default.
- W3202923009 cites W2601198875 @default.
- W3202923009 cites W2607669908 @default.
- W3202923009 cites W2672777951 @default.
- W3202923009 cites W2731130386 @default.
- W3202923009 cites W2790686372 @default.
- W3202923009 cites W2794127121 @default.
- W3202923009 cites W2801543837 @default.
- W3202923009 cites W2889454651 @default.
- W3202923009 cites W2889640732 @default.
- W3202923009 cites W2904588797 @default.
- W3202923009 cites W2905340820 @default.
- W3202923009 cites W2913836913 @default.
- W3202923009 cites W2916361025 @default.
- W3202923009 cites W2978535631 @default.
- W3202923009 cites W2989396737 @default.
- W3202923009 cites W2995162887 @default.
- W3202923009 cites W2995284758 @default.
- W3202923009 cites W2996249413 @default.
- W3202923009 cites W3014450044 @default.