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- W3202950803 endingPage "588" @default.
- W3202950803 startingPage "578" @default.
- W3202950803 abstract "Respiratory infections are a leading cause of mortality worldwide. Most of the research on the underlying disease mechanisms is based on cell culture, organoid, or surrogate animal models. Although these provide important insights, they have limitations. Cell culture models fail to recapitulate cellular interactions in the lung and animal models often do not permit high-throughput analysis of drugs or pathogen isolates; hence, there is a need for improved, scalable models. Precision-cut lung slices (PCLS), small, uniform tissue slices generated from animal or human lungs are increasingly recognized and employed as an ex vivo organotypic model. PCLS retain remarkable cellular complexity and the architecture of the lung, providing a platform to investigate respiratory pathogens in a near-native environment. Here, we review the generation and features of PCLS, their use to investigate the pathogenesis of viral and bacterial pathogens, and highlight their potential to advance respiratory infection research in the future." @default.
- W3202950803 created "2021-10-11" @default.
- W3202950803 creator A5030154885 @default.
- W3202950803 creator A5044994221 @default.
- W3202950803 creator A5056229470 @default.
- W3202950803 date "2021-10-31" @default.
- W3202950803 modified "2023-10-18" @default.
- W3202950803 title "Precision‐cut lung slices: A powerful ex vivo model to investigate respiratory infectious diseases" @default.
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- W3202950803 doi "https://doi.org/10.1111/mmi.14817" @default.
- W3202950803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34570407" @default.
- W3202950803 hasPublicationYear "2021" @default.
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