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- W3202963464 abstract "Major depressive disorder (MDD) is a debilitating disease characterized by depressed mood, loss of interest or pleasure, suicidal ideation, and reduced motivation or hopelessness. Despite considerable research, mechanisms underlying MDD remain poorly understood, and current advances in treatment are far from satisfactory. The antidepressant effect of ketamine is among the most important discoveries in psychiatric research over the last half-century. Neurobiological insights into the ketamine's effects have shed light on the mechanisms underlying antidepressant efficacy. However, mechanisms underlying the rapid and sustained antidepressant effects of ketamine remain controversial. Elucidating such mechanisms is key to identifying new therapeutic targets and developing therapeutic strategies. Accumulating evidence demonstrates the contribution of the glutamatergic pathway, the major excitatory neurotransmitter system in the central nervous system, in MDD pathophysiology and antidepressant effects. The hypothesis of a connection among the calcium signaling cascade stimulated by the glutamatergic system, neural plasticity, and epigenetic regulation of gene transcription is further supported by its associations with ketamine's antidepressant effects. This review briefly summarizes the potential mechanisms of ketamine's effects with a specific focus on glutamatergic signaling from a multiscale perspective, including behavioral, cellular, molecular, and epigenetic aspects, to provide a valuable overview of ketamine's antidepressant effects." @default.
- W3202963464 created "2021-10-11" @default.
- W3202963464 creator A5008493036 @default.
- W3202963464 creator A5011096568 @default.
- W3202963464 creator A5017205410 @default.
- W3202963464 date "2021-09-30" @default.
- W3202963464 modified "2023-10-04" @default.
- W3202963464 title "A Multiscale View of the Mechanisms Underlying Ketamine’s Antidepressant Effects: An Update on Neuronal Calcium Signaling" @default.
- W3202963464 cites W1514853588 @default.
- W3202963464 cites W1563017295 @default.
- W3202963464 cites W1733248925 @default.
- W3202963464 cites W1900565974 @default.
- W3202963464 cites W1967302087 @default.
- W3202963464 cites W1969557387 @default.
- W3202963464 cites W1976392245 @default.
- W3202963464 cites W1981097208 @default.
- W3202963464 cites W1998628114 @default.
- W3202963464 cites W2003665687 @default.
- W3202963464 cites W2018114814 @default.
- W3202963464 cites W2023081218 @default.
- W3202963464 cites W2024278554 @default.
- W3202963464 cites W2026489741 @default.
- W3202963464 cites W2031598294 @default.
- W3202963464 cites W2035421865 @default.
- W3202963464 cites W2037383099 @default.
- W3202963464 cites W2051089184 @default.
- W3202963464 cites W2051187163 @default.
- W3202963464 cites W2053610552 @default.
- W3202963464 cites W2053842655 @default.
- W3202963464 cites W2055996490 @default.
- W3202963464 cites W2057845292 @default.
- W3202963464 cites W2067535960 @default.
- W3202963464 cites W2070005343 @default.
- W3202963464 cites W2070828096 @default.
- W3202963464 cites W2072106835 @default.
- W3202963464 cites W2072745188 @default.
- W3202963464 cites W2077609442 @default.
- W3202963464 cites W2080640632 @default.
- W3202963464 cites W2087002084 @default.
- W3202963464 cites W2088861514 @default.
- W3202963464 cites W2089198034 @default.
- W3202963464 cites W2089351762 @default.
- W3202963464 cites W2091194550 @default.
- W3202963464 cites W2091363925 @default.
- W3202963464 cites W2106623141 @default.
- W3202963464 cites W2109334244 @default.
- W3202963464 cites W2109807917 @default.
- W3202963464 cites W2109851824 @default.
- W3202963464 cites W2110673629 @default.
- W3202963464 cites W2122384242 @default.
- W3202963464 cites W2123488676 @default.
- W3202963464 cites W2130685024 @default.
- W3202963464 cites W2134458928 @default.
- W3202963464 cites W2139828787 @default.
- W3202963464 cites W2144101679 @default.
- W3202963464 cites W2148160168 @default.
- W3202963464 cites W2149119305 @default.
- W3202963464 cites W2149402043 @default.
- W3202963464 cites W2154579172 @default.
- W3202963464 cites W2156668874 @default.
- W3202963464 cites W2157504436 @default.
- W3202963464 cites W2160819536 @default.
- W3202963464 cites W2166090727 @default.
- W3202963464 cites W2166563700 @default.
- W3202963464 cites W2193384210 @default.
- W3202963464 cites W2288150943 @default.
- W3202963464 cites W2340426429 @default.
- W3202963464 cites W2346390990 @default.
- W3202963464 cites W2417096145 @default.
- W3202963464 cites W2430804118 @default.
- W3202963464 cites W2474895768 @default.
- W3202963464 cites W2492077070 @default.
- W3202963464 cites W2517085860 @default.
- W3202963464 cites W2526511830 @default.
- W3202963464 cites W2581419519 @default.
- W3202963464 cites W2589198547 @default.
- W3202963464 cites W2601002904 @default.
- W3202963464 cites W2618399463 @default.
- W3202963464 cites W2631673659 @default.
- W3202963464 cites W2737813261 @default.
- W3202963464 cites W2768304164 @default.
- W3202963464 cites W2770347656 @default.
- W3202963464 cites W2775395495 @default.
- W3202963464 cites W2785770559 @default.
- W3202963464 cites W2787343838 @default.
- W3202963464 cites W2793970618 @default.
- W3202963464 cites W2794251448 @default.
- W3202963464 cites W2800551343 @default.
- W3202963464 cites W2883717630 @default.
- W3202963464 cites W2913673405 @default.
- W3202963464 cites W2916488473 @default.
- W3202963464 cites W2917916000 @default.
- W3202963464 cites W2921561928 @default.
- W3202963464 cites W2923276583 @default.
- W3202963464 cites W2935676591 @default.
- W3202963464 cites W2935995671 @default.
- W3202963464 cites W2947619125 @default.
- W3202963464 cites W2950435009 @default.
- W3202963464 cites W2950701273 @default.
- W3202963464 cites W2955851167 @default.