FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202980917> ?p ?o ?g. }

• W3202980917 abstract "Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial lung diseases with poor prognosis. Currently, few effective drugs are available for IPF. Hence, we sought to explore the role of mefunidone (MFD), a newly synthesized drug developed by our team, in lung fibrosis. In this study, MFD was found to attenuate bleomycin (BLM) -induced lung fibrosis and inflammation in mice according to Ashcroft and alveolitis scoring. The protein contents and total cell counts in bronchoalveolar lavage fluids of BLM-treated mice were also lowered by MFD. Moreover, the elevation of TGF-β/Smad2 and phosphorylation of MAPK pathways was repressed by MFD. Additionally, MFD attenuated the swelling and vacuolization of mitochondria, lowered the ratio of apoptotic cells, restored the mitochondrial membrane potential, and reversed the expression of cleaved-caspase 3, Bcl-2 and Bax. Meanwhile, the level of epithelial marker, E-cadherin, was restored by MFD, while the levels of mesenchymal markers such as Snail and vimentin were down-regulated by MFD. Besides, MFD inhibited the expression of fibronectin and α-smooth muscle actin in TGF-β treated normal human lung fibroblasts. Thus, our findings suggested that MFD could ameliorate lung fibrosis, cell apoptosis and EMT potentially via suppression of TGF-β/Smad2 and MAPK pathways." @default.
• W3202980917 created "2021-10-11" @default.
• W3202980917 creator A5006718933 @default.
• W3202980917 creator A5011277084 @default.
• W3202980917 creator A5023043755 @default.
• W3202980917 creator A5024897978 @default.
• W3202980917 creator A5039921493 @default.
• W3202980917 creator A5049334764 @default.
• W3202980917 creator A5052547525 @default.
• W3202980917 creator A5053447705 @default.
• W3202980917 creator A5056873866 @default.
• W3202980917 creator A5071178773 @default.
• W3202980917 creator A5072580570 @default.
• W3202980917 creator A5083483109 @default.
• W3202980917 creator A5089339791 @default.
• W3202980917 date "2021-09-24" @default.
• W3202980917 modified "2023-10-15" @default.
• W3202980917 title "Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice" @default.
• W3202980917 cites W1688167125 @default.
• W3202980917 cites W1925852930 @default.
• W3202980917 cites W1971064287 @default.
• W3202980917 cites W2004902531 @default.
• W3202980917 cites W2037038224 @default.
• W3202980917 cites W2052182309 @default.
• W3202980917 cites W2053589193 @default.
• W3202980917 cites W2066256524 @default.
• W3202980917 cites W2075400164 @default.
• W3202980917 cites W2100970629 @default.
• W3202980917 cites W2101547995 @default.
• W3202980917 cites W2104766198 @default.
• W3202980917 cites W2114054457 @default.
• W3202980917 cites W2234819712 @default.
• W3202980917 cites W2312535885 @default.
• W3202980917 cites W2331228735 @default.
• W3202980917 cites W2428842240 @default.
• W3202980917 cites W2529477069 @default.
• W3202980917 cites W2594146958 @default.
• W3202980917 cites W2600182715 @default.
• W3202980917 cites W2607604684 @default.
• W3202980917 cites W2671981991 @default.
• W3202980917 cites W2747861264 @default.
• W3202980917 cites W2769980186 @default.
• W3202980917 cites W2888080853 @default.
• W3202980917 cites W2927686296 @default.
• W3202980917 cites W2971496408 @default.
• W3202980917 cites W2982418079 @default.
• W3202980917 cites W3000568230 @default.
• W3202980917 cites W3004517645 @default.
• W3202980917 cites W3015686443 @default.
• W3202980917 cites W3094988418 @default.
• W3202980917 cites W3109139373 @default.
• W3202980917 cites W3111289699 @default.
• W3202980917 cites W3111642931 @default.
• W3202980917 cites W4296588288 @default.
• W3202980917 cites W612448770 @default.
• W3202980917 doi "https://doi.org/10.3389/fphar.2021.713572" @default.
• W3202980917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8499630" @default.
• W3202980917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34630088" @default.
• W3202980917 hasPublicationYear "2021" @default.
• W3202980917 type Work @default.
• W3202980917 sameAs 3202980917 @default.
• W3202980917 citedByCount "8" @default.
• W3202980917 countsByYear W32029809172022 @default.
• W3202980917 countsByYear W32029809172023 @default.
• W3202980917 crossrefType "journal-article" @default.
• W3202980917 hasAuthorship W3202980917A5006718933 @default.
• W3202980917 hasAuthorship W3202980917A5011277084 @default.
• W3202980917 hasAuthorship W3202980917A5023043755 @default.
• W3202980917 hasAuthorship W3202980917A5024897978 @default.
• W3202980917 hasAuthorship W3202980917A5039921493 @default.
• W3202980917 hasAuthorship W3202980917A5049334764 @default.
• W3202980917 hasAuthorship W3202980917A5052547525 @default.
• W3202980917 hasAuthorship W3202980917A5053447705 @default.
• W3202980917 hasAuthorship W3202980917A5056873866 @default.
• W3202980917 hasAuthorship W3202980917A5071178773 @default.
• W3202980917 hasAuthorship W3202980917A5072580570 @default.
• W3202980917 hasAuthorship W3202980917A5083483109 @default.
• W3202980917 hasAuthorship W3202980917A5089339791 @default.
• W3202980917 hasBestOaLocation W32029809171 @default.
• W3202980917 hasConcept C126322002 @default.
• W3202980917 hasConcept C142724271 @default.
• W3202980917 hasConcept C147447768 @default.
• W3202980917 hasConcept C190283241 @default.
• W3202980917 hasConcept C203014093 @default.
• W3202980917 hasConcept C204232928 @default.
• W3202980917 hasConcept C2776232574 @default.
• W3202980917 hasConcept C2776694085 @default.
• W3202980917 hasConcept C2777714996 @default.
• W3202980917 hasConcept C2777961210 @default.
• W3202980917 hasConcept C2778341716 @default.
• W3202980917 hasConcept C2780559512 @default.
• W3202980917 hasConcept C2781244666 @default.
• W3202980917 hasConcept C502942594 @default.
• W3202980917 hasConcept C55493867 @default.
• W3202980917 hasConcept C71924100 @default.
• W3202980917 hasConcept C86803240 @default.
• W3202980917 hasConceptScore W3202980917C126322002 @default.
• W3202980917 hasConceptScore W3202980917C142724271 @default.
• W3202980917 hasConceptScore W3202980917C147447768 @default.
• W3202980917 hasConceptScore W3202980917C190283241 @default.

• next