FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3202999897> ?p ?o ?g. }

• W3202999897 abstract "Aging has many effects on the female reproductive system, among which decreased oocyte quality and impaired embryo developmental potential are the most important factors affecting female fertility. However, the mechanisms underlying oocyte aging are not yet fully understood. Here, we selected normal reproductively aging female mice and constructed a protein expression profile of metaphase II (MII) oocytes from three age groups. A total of 187 differentially expressed (DE) proteins were identified, and bioinformatics analyses showed that these DE proteins were highly enriched in RNA splicing. Next, RNA-seq was performed on 2-cell embryos from these three age groups, and splicing analysis showed that a large number of splicing events and genes were discovered at this stage. Differentially spliced genes (DSGs) in the two reproductively aging groups versus the younger group were enriched in biological processes related to DNA damage repair/response. Binding motif analysis suggested that PUF60 might be one of the core splicing factors causing a decline in DNA repair capacity in the subsequent development of oocytes from reproductively aging mice, and changing the splicing pattern of its potential downstream DSG Cdk9 could partially mimic phenotypes in the reproductively aging groups. Taken together, our study suggested that the abnormal expression of splicing regulation proteins in aged MII oocytes would affect the splicing of nascent RNA after zygotic genome activation in 2-cell embryos, leading to the production of abnormally spliced transcripts of some key genes associated with DNA damage repair/response, thus affecting the developmental potential of aged oocytes." @default.
• W3202999897 created "2021-10-11" @default.
• W3202999897 creator A5001206622 @default.
• W3202999897 creator A5006680675 @default.
• W3202999897 creator A5012352582 @default.
• W3202999897 creator A5015808193 @default.
• W3202999897 creator A5022895653 @default.
• W3202999897 creator A5023349195 @default.
• W3202999897 creator A5035334249 @default.
• W3202999897 creator A5041503311 @default.
• W3202999897 creator A5061220138 @default.
• W3202999897 creator A5066188252 @default.
• W3202999897 creator A5068527047 @default.
• W3202999897 creator A5069551793 @default.
• W3202999897 creator A5076296188 @default.
• W3202999897 creator A5085122440 @default.
• W3202999897 creator A5086755732 @default.
• W3202999897 date "2021-09-28" @default.
• W3202999897 modified "2023-10-18" @default.
• W3202999897 title "Integrative proteome analysis implicates aberrant RNA splicing in impaired developmental potential of aged mouse oocytes" @default.
• W3202999897 cites W1599031322 @default.
• W3202999897 cites W1604084055 @default.
• W3202999897 cites W1975452779 @default.
• W3202999897 cites W1977609751 @default.
• W3202999897 cites W1984074400 @default.
• W3202999897 cites W1989277387 @default.
• W3202999897 cites W1990084147 @default.
• W3202999897 cites W1995224771 @default.
• W3202999897 cites W2011044632 @default.
• W3202999897 cites W2015010970 @default.
• W3202999897 cites W2018822707 @default.
• W3202999897 cites W2021957622 @default.
• W3202999897 cites W2028219039 @default.
• W3202999897 cites W2029979788 @default.
• W3202999897 cites W2036897871 @default.
• W3202999897 cites W2039912253 @default.
• W3202999897 cites W2050183773 @default.
• W3202999897 cites W2051993973 @default.
• W3202999897 cites W2055720658 @default.
• W3202999897 cites W2066231767 @default.
• W3202999897 cites W2068767807 @default.
• W3202999897 cites W2080332455 @default.
• W3202999897 cites W2086859115 @default.
• W3202999897 cites W2103017472 @default.
• W3202999897 cites W2105037453 @default.
• W3202999897 cites W2110256992 @default.
• W3202999897 cites W2110507524 @default.
• W3202999897 cites W2116220051 @default.
• W3202999897 cites W2124080033 @default.
• W3202999897 cites W2126525177 @default.
• W3202999897 cites W2127464720 @default.
• W3202999897 cites W2132073332 @default.
• W3202999897 cites W2134526812 @default.
• W3202999897 cites W2136430672 @default.
• W3202999897 cites W2141420540 @default.
• W3202999897 cites W2158217645 @default.
• W3202999897 cites W2158977008 @default.
• W3202999897 cites W2159675211 @default.
• W3202999897 cites W2164771141 @default.
• W3202999897 cites W2169456326 @default.
• W3202999897 cites W2179438025 @default.
• W3202999897 cites W2181692250 @default.
• W3202999897 cites W2218270643 @default.
• W3202999897 cites W2328681636 @default.
• W3202999897 cites W2461856584 @default.
• W3202999897 cites W2463195069 @default.
• W3202999897 cites W2537623931 @default.
• W3202999897 cites W2551312221 @default.
• W3202999897 cites W2595736323 @default.
• W3202999897 cites W2654333968 @default.
• W3202999897 cites W2735051861 @default.
• W3202999897 cites W2751871286 @default.
• W3202999897 cites W2766682035 @default.
• W3202999897 cites W2790887288 @default.
• W3202999897 cites W2791002158 @default.
• W3202999897 cites W2803233756 @default.
• W3202999897 cites W2804054946 @default.
• W3202999897 cites W2806452366 @default.
• W3202999897 cites W2810268516 @default.
• W3202999897 cites W2899760200 @default.
• W3202999897 cites W2906410628 @default.
• W3202999897 cites W2942501466 @default.
• W3202999897 cites W2946145793 @default.
• W3202999897 cites W2950595506 @default.
• W3202999897 cites W2968041093 @default.
• W3202999897 cites W2973086200 @default.
• W3202999897 cites W2975979611 @default.
• W3202999897 cites W2988820761 @default.
• W3202999897 cites W2996588976 @default.
• W3202999897 cites W2998101582 @default.
• W3202999897 cites W3005049484 @default.
• W3202999897 cites W3035653582 @default.
• W3202999897 cites W3202999897 @default.
• W3202999897 cites W4233698560 @default.
• W3202999897 doi "https://doi.org/10.1111/acel.13482" @default.
• W3202999897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8520726" @default.
• W3202999897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34582091" @default.
• W3202999897 hasPublicationYear "2021" @default.
• W3202999897 type Work @default.
• W3202999897 sameAs 3202999897 @default.

• next