FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203000650> ?p ?o ?g. }

• W3203000650 abstract "Abstract The avian hearing organ is the basilar papilla that, in sharp contrast to the mammalian cochlea, can regenerate sensory hair cells and thereby recover from complete deafness within weeks. The mechanisms that trigger, sustain, and terminate the regenerative response in vivo are largely unknown. Here, we profile the changes in gene expression in the chicken basilar papilla after aminoglycoside antibiotic-induced hair cell loss using RNA-sequencing. The most prominent changes in gene expression were linked to the upregulation of interferon response genes which occurred in supporting cells, confirmed by single-cell RNA-sequencing and in situ hybridization. We determined that the JAK/STAT signaling pathway is essential for the interferon gene response in supporting cells, set in motion by hair cell loss. Four days after ototoxic damage, we identified newly regenerated, nascent auditory hair cells that express genes linked to termination of the interferon response. These cells are incipient modified neurons that represent a population of hair cells en route towards obtaining their location-specific and fully functional cell identity. The robust, transient expression of immune-related genes in supporting cells suggests a potential functional involvement of JAK/STAT signaling and interferon in sensory hair cell regeneration." @default.
• W3203000650 created "2021-10-11" @default.
• W3203000650 creator A5028448184 @default.
• W3203000650 creator A5067865290 @default.
• W3203000650 creator A5075318757 @default.
• W3203000650 creator A5081258430 @default.
• W3203000650 creator A5081499334 @default.
• W3203000650 date "2021-09-24" @default.
• W3203000650 modified "2023-09-27" @default.
• W3203000650 title "Chicken Auditory Supporting Cells Express Interferon Response Genes during Regeneration towards Nascent Sensory Hair Cells In Vivo" @default.
• W3203000650 cites W1482140147 @default.
• W3203000650 cites W1492867725 @default.
• W3203000650 cites W1501063259 @default.
• W3203000650 cites W1530345560 @default.
• W3203000650 cites W1664617222 @default.
• W3203000650 cites W1752420865 @default.
• W3203000650 cites W1964734834 @default.
• W3203000650 cites W1968120120 @default.
• W3203000650 cites W1968143827 @default.
• W3203000650 cites W1971659644 @default.
• W3203000650 cites W1974496783 @default.
• W3203000650 cites W1976881355 @default.
• W3203000650 cites W1977745877 @default.
• W3203000650 cites W1978468933 @default.
• W3203000650 cites W1979510752 @default.
• W3203000650 cites W1991349062 @default.
• W3203000650 cites W1993652778 @default.
• W3203000650 cites W1998510940 @default.
• W3203000650 cites W2000191247 @default.
• W3203000650 cites W2000920877 @default.
• W3203000650 cites W2005154068 @default.
• W3203000650 cites W2006289803 @default.
• W3203000650 cites W2013935392 @default.
• W3203000650 cites W2015692574 @default.
• W3203000650 cites W2018514799 @default.
• W3203000650 cites W2024363819 @default.
• W3203000650 cites W2024661068 @default.
• W3203000650 cites W2024964928 @default.
• W3203000650 cites W2025681652 @default.
• W3203000650 cites W2026012549 @default.
• W3203000650 cites W2029824528 @default.
• W3203000650 cites W2032774986 @default.
• W3203000650 cites W2034654482 @default.
• W3203000650 cites W2036966983 @default.
• W3203000650 cites W2037904195 @default.
• W3203000650 cites W2038466084 @default.
• W3203000650 cites W2042825217 @default.
• W3203000650 cites W2047573503 @default.
• W3203000650 cites W2051753182 @default.
• W3203000650 cites W2053300095 @default.
• W3203000650 cites W2054177024 @default.
• W3203000650 cites W2058662928 @default.
• W3203000650 cites W2059763574 @default.
• W3203000650 cites W2066469540 @default.
• W3203000650 cites W2068767807 @default.
• W3203000650 cites W2069515096 @default.
• W3203000650 cites W2073834370 @default.
• W3203000650 cites W2076141253 @default.
• W3203000650 cites W2078660872 @default.
• W3203000650 cites W2079165672 @default.
• W3203000650 cites W2079645940 @default.
• W3203000650 cites W2083294419 @default.
• W3203000650 cites W2085157715 @default.
• W3203000650 cites W2087604523 @default.
• W3203000650 cites W2091559596 @default.
• W3203000650 cites W2098494787 @default.
• W3203000650 cites W2101561402 @default.
• W3203000650 cites W2107018762 @default.
• W3203000650 cites W2107277218 @default.
• W3203000650 cites W2110952289 @default.
• W3203000650 cites W2111218879 @default.
• W3203000650 cites W2114104545 @default.
• W3203000650 cites W2115094414 @default.
• W3203000650 cites W2118551155 @default.
• W3203000650 cites W2121405816 @default.
• W3203000650 cites W2121683613 @default.
• W3203000650 cites W2123426485 @default.
• W3203000650 cites W2123630843 @default.
• W3203000650 cites W2125069729 @default.
• W3203000650 cites W2138317563 @default.
• W3203000650 cites W2142018200 @default.
• W3203000650 cites W2143689381 @default.
• W3203000650 cites W2149330714 @default.
• W3203000650 cites W2153472997 @default.
• W3203000650 cites W2156104877 @default.
• W3203000650 cites W2156993914 @default.
• W3203000650 cites W2158797557 @default.
• W3203000650 cites W2163480897 @default.
• W3203000650 cites W2169456326 @default.
• W3203000650 cites W2174476282 @default.
• W3203000650 cites W2175664647 @default.
• W3203000650 cites W2195309379 @default.
• W3203000650 cites W2307322413 @default.
• W3203000650 cites W2462759503 @default.
• W3203000650 cites W2580190897 @default.
• W3203000650 cites W2580555388 @default.
• W3203000650 cites W2603122369 @default.
• W3203000650 cites W2605611918 @default.
• W3203000650 cites W2606650217 @default.
• W3203000650 cites W2609733407 @default.

• next