Matches in SemOpenAlex for { <https://semopenalex.org/work/W3203003208> ?p ?o ?g. }
- W3203003208 abstract "Primary cilia are microtubule based sensory organelles important for receiving and processing cellular signals. Recent studies have shown that cilia also release extracellular vesicles (EVs). Because EVs have been shown to exert various physiological functions, these findings have the potential to alter our understanding of how primary cilia regulate specific signalling pathways. So far the focus has been on lgEVs budding directly from the ciliary membrane. An association between cilia and MVB-derived smEVs has not yet been described. We show that ciliary mutant mammalian cells demonstrate increased secretion of small EVs (smEVs) and a change in EV composition. Characterisation of smEV cargo identified signalling molecules that are differentially loaded upon ciliary dysfunction. Furthermore, we show that these smEVs are biologically active and modulate the WNT response in recipient cells. These results provide us with insights into smEV-dependent ciliary signalling mechanisms which might underly ciliopathy disease pathogenesis." @default.
- W3203003208 created "2021-10-11" @default.
- W3203003208 creator A5004169647 @default.
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- W3203003208 creator A5030358588 @default.
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- W3203003208 creator A5060118221 @default.
- W3203003208 creator A5076115710 @default.
- W3203003208 date "2021-09-27" @default.
- W3203003208 modified "2023-10-06" @default.
- W3203003208 title "Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles" @default.
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